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Anti-inflammatory and analgesic effects of Daphne retusa Hemsl.
J Ethnopharmacol. 2008 Oct 30; 120(1):118-22.JE

Abstract

Daphne retusa Hemsl. belongs to the genus Daphne, a member of Thymelaeaceae family. The barks and stems of Daphne retusa are used as a folkloric medicine 'Zhu Shi Ma' in Western China because of its effects of detumescence and acesodyne. In this paper, we investigate the anti-inflammatory and analgesic effects of the 75% ethanol extract of the stems and barks of Daphne retusa and different fractions partitioned with petroleum ether, methylene chloride, ethyl acetate and n-butanol, respectively. The anti-inflammatory effects were evaluated using xylene-induced ear oedema in mice and carrageenan-induced paw oedema in rats, while the acetic acid-induced writhing test and hot-plate test as models for evaluating the centrally and peripherally analgesic activity. The results showed the plant has significant anti-inflammatory and analgesic effects (P<0.05-0.01). Meanwhile, the result of the acute toxicity test at which the MTD was above 5g/kg indicates that the plant extract is relatively safe in, and/or non-toxic to, mice. The findings of these experimental animal studies indicate that the Daphne retusa ethanol extract possesses anti-inflammatory and analgesic properties, and thus provide pharmacological support to folkloric, ethnomedical uses of 'Zhu shima' in the treatment and/of management of anti-inflammatory and painful conditions in China.

Authors+Show Affiliations

School of Pharmacy, Shanghai Jiaotong University, Shanghai 200240, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18692124

Citation

Hu, Xiaojia, et al. "Anti-inflammatory and Analgesic Effects of Daphne Retusa Hemsl." Journal of Ethnopharmacology, vol. 120, no. 1, 2008, pp. 118-22.
Hu X, Jin H, Xu W, et al. Anti-inflammatory and analgesic effects of Daphne retusa Hemsl. J Ethnopharmacol. 2008;120(1):118-22.
Hu, X., Jin, H., Xu, W., Zhang, W., Liu, X., Yan, S., Chen, M., Li, J., & Zhang, W. D. (2008). Anti-inflammatory and analgesic effects of Daphne retusa Hemsl. Journal of Ethnopharmacology, 120(1), 118-22. https://doi.org/10.1016/j.jep.2008.07.010
Hu X, et al. Anti-inflammatory and Analgesic Effects of Daphne Retusa Hemsl. J Ethnopharmacol. 2008 Oct 30;120(1):118-22. PubMed PMID: 18692124.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory and analgesic effects of Daphne retusa Hemsl. AU - Hu,Xiaojia, AU - Jin,Huizi, AU - Xu,Wenzheng, AU - Zhang,Wei, AU - Liu,Xiaohua, AU - Yan,Shikai, AU - Chen,Ming, AU - Li,Jianqiang, AU - Zhang,Wei-dong, Y1 - 2008/07/18/ PY - 2008/03/11/received PY - 2008/05/27/revised PY - 2008/07/12/accepted PY - 2008/8/12/pubmed PY - 2009/1/28/medline PY - 2008/8/12/entrez SP - 118 EP - 22 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 120 IS - 1 N2 - Daphne retusa Hemsl. belongs to the genus Daphne, a member of Thymelaeaceae family. The barks and stems of Daphne retusa are used as a folkloric medicine 'Zhu Shi Ma' in Western China because of its effects of detumescence and acesodyne. In this paper, we investigate the anti-inflammatory and analgesic effects of the 75% ethanol extract of the stems and barks of Daphne retusa and different fractions partitioned with petroleum ether, methylene chloride, ethyl acetate and n-butanol, respectively. The anti-inflammatory effects were evaluated using xylene-induced ear oedema in mice and carrageenan-induced paw oedema in rats, while the acetic acid-induced writhing test and hot-plate test as models for evaluating the centrally and peripherally analgesic activity. The results showed the plant has significant anti-inflammatory and analgesic effects (P<0.05-0.01). Meanwhile, the result of the acute toxicity test at which the MTD was above 5g/kg indicates that the plant extract is relatively safe in, and/or non-toxic to, mice. The findings of these experimental animal studies indicate that the Daphne retusa ethanol extract possesses anti-inflammatory and analgesic properties, and thus provide pharmacological support to folkloric, ethnomedical uses of 'Zhu shima' in the treatment and/of management of anti-inflammatory and painful conditions in China. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/18692124/Anti_inflammatory_and_analgesic_effects_of_Daphne_retusa_Hemsl_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(08)00386-3 DB - PRIME DP - Unbound Medicine ER -