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Complementary and alternative medicine for perinatal depression.
J Affect Disord. 2009 Jan; 112(1-3):1-10.JA

Abstract

INTRODUCTION

Perinatal Major Depressive Disorder (MDD) is common and poses particular treatment dilemmas. Complementary and Alternative Medicine (CAM) treatments are widely used, accessible, and understudied for well-defined psychiatric indications. Women are more likely than men to both suffer from MDD and use CAM.

METHODS

A PubMed/Medline search was conducted to assess the evidence base for commonly utilized CAM treatments, MDD, and perinatal depression.

RESULTS

Among CAM treatments, omega-3 fatty acids have received the most specific study in terms of epidemiological, preclinical, and clinical research for perinatal depression. Three randomized placebo-controlled trials have been conducted in which investigators assessed omega-3 fatty acids vs. placebo for perinatal depression, with conflicting results. CAM interventions that can be easily added to a treatment plan with little risk and general health benefits for most women include omega-3 fatty acids, exercise, and folate, although data are insufficient at this time to recommend any of these as monotherapy for perinatal depression. S-adenosyl-methionine (SAMe) and bright light therapy may be reasonable to consider based on the evidence in MDD. St. John's Wort requires further study with regard to safety in pregnancy, and drug interactions can be a potential problem.

DISCUSSION

Further study is required to elucidate the role of CAM treatments for perinatal depression, and the clinical context of perinatal depression requires safe, effective, and accessible treatment options.

Authors+Show Affiliations

Women's Mental Health Center, University of Texas Southwestern Medical Center, 6363 Forest Park, Suite 800, Dallas, TX 75235-9086, United States. marlene.freeman@utsouthwestern.edu

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18692251

Citation

Freeman, Marlene P.. "Complementary and Alternative Medicine for Perinatal Depression." Journal of Affective Disorders, vol. 112, no. 1-3, 2009, pp. 1-10.
Freeman MP. Complementary and alternative medicine for perinatal depression. J Affect Disord. 2009;112(1-3):1-10.
Freeman, M. P. (2009). Complementary and alternative medicine for perinatal depression. Journal of Affective Disorders, 112(1-3), 1-10. https://doi.org/10.1016/j.jad.2008.06.017
Freeman MP. Complementary and Alternative Medicine for Perinatal Depression. J Affect Disord. 2009;112(1-3):1-10. PubMed PMID: 18692251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complementary and alternative medicine for perinatal depression. A1 - Freeman,Marlene P, Y1 - 2008/08/08/ PY - 2008/03/14/received PY - 2008/06/17/revised PY - 2008/06/24/accepted PY - 2008/8/12/pubmed PY - 2009/5/28/medline PY - 2008/8/12/entrez SP - 1 EP - 10 JF - Journal of affective disorders JO - J Affect Disord VL - 112 IS - 1-3 N2 - INTRODUCTION: Perinatal Major Depressive Disorder (MDD) is common and poses particular treatment dilemmas. Complementary and Alternative Medicine (CAM) treatments are widely used, accessible, and understudied for well-defined psychiatric indications. Women are more likely than men to both suffer from MDD and use CAM. METHODS: A PubMed/Medline search was conducted to assess the evidence base for commonly utilized CAM treatments, MDD, and perinatal depression. RESULTS: Among CAM treatments, omega-3 fatty acids have received the most specific study in terms of epidemiological, preclinical, and clinical research for perinatal depression. Three randomized placebo-controlled trials have been conducted in which investigators assessed omega-3 fatty acids vs. placebo for perinatal depression, with conflicting results. CAM interventions that can be easily added to a treatment plan with little risk and general health benefits for most women include omega-3 fatty acids, exercise, and folate, although data are insufficient at this time to recommend any of these as monotherapy for perinatal depression. S-adenosyl-methionine (SAMe) and bright light therapy may be reasonable to consider based on the evidence in MDD. St. John's Wort requires further study with regard to safety in pregnancy, and drug interactions can be a potential problem. DISCUSSION: Further study is required to elucidate the role of CAM treatments for perinatal depression, and the clinical context of perinatal depression requires safe, effective, and accessible treatment options. SN - 0165-0327 UR - https://www.unboundmedicine.com/medline/citation/18692251/Complementary_and_alternative_medicine_for_perinatal_depression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(08)00274-7 DB - PRIME DP - Unbound Medicine ER -