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Evaluation of circulating vascular endothelial growth factor and soluble adhesion molecules as reliable predictors of native arteriovenous fistula thrombosis in chronic hemodialysis patients.
Clin Biochem. 2008 Oct; 41(14-15):1175-80.CB

Abstract

OBJECTIVES

We evaluated the possibility of using circulating vascular endothelial growth factor (VEGF) and soluble adhesion molecules as reliable predictors of native arteriovenous (AV) fistula thrombosis in chronic hemodialysis (HD) patients.

DESIGN AND METHODS

This study included 62 HD patients (34 with thrombosed and 28 with non-thrombosed AV fistulas) and 21 healthy volunteers. Serum VEGF, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble E-selectin (sE-selectin) were measured using ELISA technique.

RESULTS

VEGF, sVCAM-1, sICAM-1 and sE-selectin median levels were higher in HD patients compared to controls (p=0.000 for all parameters). Increased median levels of VEGF and sVCAM-1 were demonstrated in HD patients with thrombosed AV fistulas compared to HD patients with non-thrombosed AV fistulas (p=0.003 and 0.000, respectively). A significant positive correlation has been found between VEGF and sVCAM-1 in HD patients with thombosed AV fistulas (r=0.525, p=0.001).

CONCLUSIONS

The assessment of serum VEGF and sVCAM-1 might be useful for the identification of the chronic HD patients at an increased risk for native AV fistulas thrombosis. The clinical relevance of these observations warrants further investigations.

Authors+Show Affiliations

Biochemistry Department, Faculty of Science, Ain Shams University, 11566, Abbassia, Cairo, Egypt.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18692491

Citation

Zohny, Samir F., and Mahmoud Abd el-Fattah. "Evaluation of Circulating Vascular Endothelial Growth Factor and Soluble Adhesion Molecules as Reliable Predictors of Native Arteriovenous Fistula Thrombosis in Chronic Hemodialysis Patients." Clinical Biochemistry, vol. 41, no. 14-15, 2008, pp. 1175-80.
Zohny SF, Abd el-Fattah M. Evaluation of circulating vascular endothelial growth factor and soluble adhesion molecules as reliable predictors of native arteriovenous fistula thrombosis in chronic hemodialysis patients. Clin Biochem. 2008;41(14-15):1175-80.
Zohny, S. F., & Abd el-Fattah, M. (2008). Evaluation of circulating vascular endothelial growth factor and soluble adhesion molecules as reliable predictors of native arteriovenous fistula thrombosis in chronic hemodialysis patients. Clinical Biochemistry, 41(14-15), 1175-80. https://doi.org/10.1016/j.clinbiochem.2008.07.006
Zohny SF, Abd el-Fattah M. Evaluation of Circulating Vascular Endothelial Growth Factor and Soluble Adhesion Molecules as Reliable Predictors of Native Arteriovenous Fistula Thrombosis in Chronic Hemodialysis Patients. Clin Biochem. 2008;41(14-15):1175-80. PubMed PMID: 18692491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of circulating vascular endothelial growth factor and soluble adhesion molecules as reliable predictors of native arteriovenous fistula thrombosis in chronic hemodialysis patients. AU - Zohny,Samir F, AU - Abd el-Fattah,Mahmoud, Y1 - 2008/07/28/ PY - 2008/03/20/received PY - 2008/07/07/revised PY - 2008/07/10/accepted PY - 2008/8/12/pubmed PY - 2008/12/17/medline PY - 2008/8/12/entrez SP - 1175 EP - 80 JF - Clinical biochemistry JO - Clin Biochem VL - 41 IS - 14-15 N2 - OBJECTIVES: We evaluated the possibility of using circulating vascular endothelial growth factor (VEGF) and soluble adhesion molecules as reliable predictors of native arteriovenous (AV) fistula thrombosis in chronic hemodialysis (HD) patients. DESIGN AND METHODS: This study included 62 HD patients (34 with thrombosed and 28 with non-thrombosed AV fistulas) and 21 healthy volunteers. Serum VEGF, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble E-selectin (sE-selectin) were measured using ELISA technique. RESULTS: VEGF, sVCAM-1, sICAM-1 and sE-selectin median levels were higher in HD patients compared to controls (p=0.000 for all parameters). Increased median levels of VEGF and sVCAM-1 were demonstrated in HD patients with thrombosed AV fistulas compared to HD patients with non-thrombosed AV fistulas (p=0.003 and 0.000, respectively). A significant positive correlation has been found between VEGF and sVCAM-1 in HD patients with thombosed AV fistulas (r=0.525, p=0.001). CONCLUSIONS: The assessment of serum VEGF and sVCAM-1 might be useful for the identification of the chronic HD patients at an increased risk for native AV fistulas thrombosis. The clinical relevance of these observations warrants further investigations. SN - 1873-2933 UR - https://www.unboundmedicine.com/medline/citation/18692491/Evaluation_of_circulating_vascular_endothelial_growth_factor_and_soluble_adhesion_molecules_as_reliable_predictors_of_native_arteriovenous_fistula_thrombosis_in_chronic_hemodialysis_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(08)00270-1 DB - PRIME DP - Unbound Medicine ER -