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Impact of glycemic variations on the regulation of androgen metabolism in obese women with polycystic ovary syndrome.
Fertil Steril. 2009 Jul; 92(1):271-6.FS

Abstract

OBJECTIVE

To assess the influence of alterations in glucose concentrations on androgen levels in patients with polycystic ovary syndrome (PCOS) and in healthy controls.

DESIGN

Prospective, controlled study.

SETTING

Tertiary care center.

PATIENT(S)

Seven patients with PCOS and 20 healthy controls.

INTERVENTION(S)

Hyperinsulinemic glucose clamp study with stepwise reduction of the plasma glucose level from hyperglycemia to hypoglycemia.

MAIN OUTCOME MEASURE(S)

Concentrations of insulin, C-peptide, cortisol, T, androstenedione, 17-hydroxyprogesterone, DHEA, and DHEAS during hyperglycemia, euglycemia, and hypoglycemia.

RESULT(S)

Total T levels and the free androgen index were significantly higher in the PCOS group at baseline and throughout the clamp. The levels of T, androstenedione, DHEAS, and 17-hydroxyprogesterone were not influenced by short-term changes of plasma glucose concentrations in both groups. However, hypoglycemia led to a significant increase in DHEA levels in PCOS patients as well as in controls. Cortisol levels were not increased during hypoglycemia in either group.

CONCLUSION(S)

In contrast to men, androgen levels are not influenced by short-term changes of plasma glucose levels in PCOS patients and in healthy women. However, DHEA concentrations increase with decreasing glucose levels independently from an activation of the hypothalamic-pituitary-adrenal axis. This supports a gender difference regarding the counterregulatory hormone response to hypoglycemia.

Authors+Show Affiliations

Center for Hormonal and Metabolic Disease, Reproductive Medicine, Gynecologic Endocrinology, and Prenatal Medicine, Endokrinologikum Hamburg, Lornsenstrasse 4-6, Hamburg, Germany. A.K.Ludwig@web.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18692843

Citation

Ludwig, Annika K., et al. "Impact of Glycemic Variations On the Regulation of Androgen Metabolism in Obese Women With Polycystic Ovary Syndrome." Fertility and Sterility, vol. 92, no. 1, 2009, pp. 271-6.
Ludwig AK, Goharian LG, Dietze T, et al. Impact of glycemic variations on the regulation of androgen metabolism in obese women with polycystic ovary syndrome. Fertil Steril. 2009;92(1):271-6.
Ludwig, A. K., Goharian, L. G., Dietze, T., Tauchert, S., Rudolf, S., Diedrich, K., Schweiger, U., & Oltmanns, K. M. (2009). Impact of glycemic variations on the regulation of androgen metabolism in obese women with polycystic ovary syndrome. Fertility and Sterility, 92(1), 271-6. https://doi.org/10.1016/j.fertnstert.2008.05.052
Ludwig AK, et al. Impact of Glycemic Variations On the Regulation of Androgen Metabolism in Obese Women With Polycystic Ovary Syndrome. Fertil Steril. 2009;92(1):271-6. PubMed PMID: 18692843.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of glycemic variations on the regulation of androgen metabolism in obese women with polycystic ovary syndrome. AU - Ludwig,Annika K, AU - Goharian,Lilian G, AU - Dietze,Theresa, AU - Tauchert,Sacha, AU - Rudolf,Sebastian, AU - Diedrich,Klaus, AU - Schweiger,Ulrich, AU - Oltmanns,Kerstin M, Y1 - 2008/08/09/ PY - 2008/04/24/received PY - 2008/05/08/revised PY - 2008/05/15/accepted PY - 2008/8/12/pubmed PY - 2009/7/30/medline PY - 2008/8/12/entrez SP - 271 EP - 6 JF - Fertility and sterility JO - Fertil. Steril. VL - 92 IS - 1 N2 - OBJECTIVE: To assess the influence of alterations in glucose concentrations on androgen levels in patients with polycystic ovary syndrome (PCOS) and in healthy controls. DESIGN: Prospective, controlled study. SETTING: Tertiary care center. PATIENT(S): Seven patients with PCOS and 20 healthy controls. INTERVENTION(S): Hyperinsulinemic glucose clamp study with stepwise reduction of the plasma glucose level from hyperglycemia to hypoglycemia. MAIN OUTCOME MEASURE(S): Concentrations of insulin, C-peptide, cortisol, T, androstenedione, 17-hydroxyprogesterone, DHEA, and DHEAS during hyperglycemia, euglycemia, and hypoglycemia. RESULT(S): Total T levels and the free androgen index were significantly higher in the PCOS group at baseline and throughout the clamp. The levels of T, androstenedione, DHEAS, and 17-hydroxyprogesterone were not influenced by short-term changes of plasma glucose concentrations in both groups. However, hypoglycemia led to a significant increase in DHEA levels in PCOS patients as well as in controls. Cortisol levels were not increased during hypoglycemia in either group. CONCLUSION(S): In contrast to men, androgen levels are not influenced by short-term changes of plasma glucose levels in PCOS patients and in healthy women. However, DHEA concentrations increase with decreasing glucose levels independently from an activation of the hypothalamic-pituitary-adrenal axis. This supports a gender difference regarding the counterregulatory hormone response to hypoglycemia. SN - 1556-5653 UR - https://www.unboundmedicine.com/medline/citation/18692843/Impact_of_glycemic_variations_on_the_regulation_of_androgen_metabolism_in_obese_women_with_polycystic_ovary_syndrome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0015-0282(08)01155-2 DB - PRIME DP - Unbound Medicine ER -