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Interleukin 6 -174(G>C) gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in diabetes type 1 children.
Diabetes Res Clin Pract 2008; 82(1):108-12DR

Abstract

The aim of the study was to assess the relationship between IL-6 gene polymorphism at -174(G>C) and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (DM1) in children. 200 children with DM1 aged 13.23+/-3.54 years and 172 healthy controls were analyzed. The IL-6 gene -174(G>C) polymorphism at the promoter region of the gene was analyzed by the PCR-RFLP method. The genotype distribution was significantly different in diabetic children as compared to the healthy controls (p=0.01). In DM1 patients GC heterozygotes were the most common (52.5%), while CC homozygotes accuted for 29% and GG homozygotes only for 18% of cases. In contrast, GG homozygotes were much more frequent among healthy children (31%). Besides, the GG homozygotes were significantly more frequent among diabetic children with celiac disease (p=0.04) in relation to those without autoimmune complications. In children with autoimmune thyroiditis, the distribution of the IL-6 genotypes was similar to that seen in diabetic patients without autoimmune complications (p=0.24). The results of our study suggest that the diabetic children, who have IL-6 gene -174GG genotype may have an increased risk for celiac disease development.

Authors+Show Affiliations

Diabetology Unit, Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdańsk, 80-952 Gdańsk, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18692934

Citation

Myśliwiec, Małgorzata, et al. "Interleukin 6 -174(G>C) Gene Polymorphism Is Related to Celiac Disease and Autoimmune Thyroiditis Coincidence in Diabetes Type 1 Children." Diabetes Research and Clinical Practice, vol. 82, no. 1, 2008, pp. 108-12.
Myśliwiec M, Myśliwska J, Zorena K, et al. Interleukin 6 -174(G>C) gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in diabetes type 1 children. Diabetes Res Clin Pract. 2008;82(1):108-12.
Myśliwiec, M., Myśliwska, J., Zorena, K., Balcerska, A., Malinowska, E., & Wiśniewski, P. (2008). Interleukin 6 -174(G>C) gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in diabetes type 1 children. Diabetes Research and Clinical Practice, 82(1), pp. 108-12. doi:10.1016/j.diabres.2008.07.004.
Myśliwiec M, et al. Interleukin 6 -174(G>C) Gene Polymorphism Is Related to Celiac Disease and Autoimmune Thyroiditis Coincidence in Diabetes Type 1 Children. Diabetes Res Clin Pract. 2008;82(1):108-12. PubMed PMID: 18692934.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interleukin 6 -174(G>C) gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in diabetes type 1 children. AU - Myśliwiec,Małgorzata, AU - Myśliwska,Jolanta, AU - Zorena,Katarzyna, AU - Balcerska,Anna, AU - Malinowska,Ewa, AU - Wiśniewski,Piotr, Y1 - 2008/08/09/ PY - 2008/03/04/received PY - 2008/06/30/revised PY - 2008/07/02/accepted PY - 2008/8/12/pubmed PY - 2009/2/10/medline PY - 2008/8/12/entrez SP - 108 EP - 12 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 82 IS - 1 N2 - The aim of the study was to assess the relationship between IL-6 gene polymorphism at -174(G>C) and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (DM1) in children. 200 children with DM1 aged 13.23+/-3.54 years and 172 healthy controls were analyzed. The IL-6 gene -174(G>C) polymorphism at the promoter region of the gene was analyzed by the PCR-RFLP method. The genotype distribution was significantly different in diabetic children as compared to the healthy controls (p=0.01). In DM1 patients GC heterozygotes were the most common (52.5%), while CC homozygotes accuted for 29% and GG homozygotes only for 18% of cases. In contrast, GG homozygotes were much more frequent among healthy children (31%). Besides, the GG homozygotes were significantly more frequent among diabetic children with celiac disease (p=0.04) in relation to those without autoimmune complications. In children with autoimmune thyroiditis, the distribution of the IL-6 genotypes was similar to that seen in diabetic patients without autoimmune complications (p=0.24). The results of our study suggest that the diabetic children, who have IL-6 gene -174GG genotype may have an increased risk for celiac disease development. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18692934/Interleukin_6__174_G>C__gene_polymorphism_is_related_to_celiac_disease_and_autoimmune_thyroiditis_coincidence_in_diabetes_type_1_children_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(08)00316-1 DB - PRIME DP - Unbound Medicine ER -