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The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin.
Phytomedicine. 2008 Dec; 15(12):1069-78.P

Abstract

Identification of natural health products that might benefit skeletal health could reduce the negative impact of osteoporotic bone fractures upon society. The objectives of this study were to evaluate an animal model of postmenopausal osteoporosis and to search for evidence that curcumin reduces bone mineral losses in a dose-dependent manner when endogenous estrogen levels are reduced. Bone mineral density was measured at the spine, femur and whole body before and at 2, 4 and 6 months after ovariectomy in each of 40 mature rats. Serum osteocalcin and C-telopeptide were measured as indicators of bone formation and resorption rates. Femoral compressive strength was measured at 6 months. Ovariectomy alone resulted in loss of mineral from the spine (p<0.005) and an increase in osteocalcin levels (p<0.05). At the same time, there was an increase in energy to fracture (p<0.01) due to an increased bone size. When ovariectomized animals were given etidronate there was no loss of mineral from the spine, the size of the femur increased (p<0.005), C-telopeptide levels were reduced (p<0.001) and femoral compressive strength increased (p<0.025). Administration of curcumin to ovariectomized animals resulted in changes that were intermediate between those produced by etidronate and by ovariectomy alone. The increase in femur size produced by the highest dose of curcumin was statistically significant (p< 0.01) and curcumin administration resulted in a significant, dose dependent, increase in energy to fracture. Curcumin produces beneficial changes in bone turnover and increases in bone strength using the ovariectomized mature rat model of postmenopausal osteoporosis.

Authors+Show Affiliations

Department of Radiology, McMaster University, Hamilton, Ontario, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18693096

Citation

French, D L., et al. "The Ovariectomized, Mature Rat Model of Postmenopausal Osteoporosis: an Assessment of the Bone Sparing Effects of Curcumin." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 15, no. 12, 2008, pp. 1069-78.
French DL, Muir JM, Webber CE. The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin. Phytomedicine. 2008;15(12):1069-78.
French, D. L., Muir, J. M., & Webber, C. E. (2008). The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 15(12), 1069-78. https://doi.org/10.1016/j.phymed.2008.06.007
French DL, Muir JM, Webber CE. The Ovariectomized, Mature Rat Model of Postmenopausal Osteoporosis: an Assessment of the Bone Sparing Effects of Curcumin. Phytomedicine. 2008;15(12):1069-78. PubMed PMID: 18693096.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ovariectomized, mature rat model of postmenopausal osteoporosis: an assessment of the bone sparing effects of curcumin. AU - French,D L, AU - Muir,J M, AU - Webber,C E, Y1 - 2008/08/06/ PY - 2007/09/12/received PY - 2008/06/06/revised PY - 2008/06/06/accepted PY - 2008/8/12/pubmed PY - 2009/1/31/medline PY - 2008/8/12/entrez SP - 1069 EP - 78 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 15 IS - 12 N2 - Identification of natural health products that might benefit skeletal health could reduce the negative impact of osteoporotic bone fractures upon society. The objectives of this study were to evaluate an animal model of postmenopausal osteoporosis and to search for evidence that curcumin reduces bone mineral losses in a dose-dependent manner when endogenous estrogen levels are reduced. Bone mineral density was measured at the spine, femur and whole body before and at 2, 4 and 6 months after ovariectomy in each of 40 mature rats. Serum osteocalcin and C-telopeptide were measured as indicators of bone formation and resorption rates. Femoral compressive strength was measured at 6 months. Ovariectomy alone resulted in loss of mineral from the spine (p<0.005) and an increase in osteocalcin levels (p<0.05). At the same time, there was an increase in energy to fracture (p<0.01) due to an increased bone size. When ovariectomized animals were given etidronate there was no loss of mineral from the spine, the size of the femur increased (p<0.005), C-telopeptide levels were reduced (p<0.001) and femoral compressive strength increased (p<0.025). Administration of curcumin to ovariectomized animals resulted in changes that were intermediate between those produced by etidronate and by ovariectomy alone. The increase in femur size produced by the highest dose of curcumin was statistically significant (p< 0.01) and curcumin administration resulted in a significant, dose dependent, increase in energy to fracture. Curcumin produces beneficial changes in bone turnover and increases in bone strength using the ovariectomized mature rat model of postmenopausal osteoporosis. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/18693096/The_ovariectomized_mature_rat_model_of_postmenopausal_osteoporosis:_an_assessment_of_the_bone_sparing_effects_of_curcumin_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(08)00115-3 DB - PRIME DP - Unbound Medicine ER -