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Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice.
Phytomedicine. 2008 Nov; 15(11):940-5.P

Abstract

The xanthine oxidase (XOD) inhibitory activity and anti-hyperuricemia effect in mice of Cinnamomum osmophloeum, which is an endemic tree in Taiwan, were evaluated in this study. The results demonstrated that the essential oil of C. osmophloeum leaves presented the strongest XOD inhibition activity (IC(50)=16.3 μg/ml); however, no significant XOD inhibition activities were found in ethanolic and hot water extracts. Furthermore, among the main compounds of essential oil, the cinnamaldehyde exhibited the potent XOD inhibition activity with an IC(50)=8.4 μg/ml. Besides, the reducing serum uric acid levels in oxonate-induced mice by cinnamaldehyde were further investigated. The hyperuricemic mice were oral administrated cinnamaldehyde at a dosage of 150 mg/kg, the uric acid value in serum was reduced from 5.25±0.63 to 2.10±0.04 mg/dl, the levels of serum uric acid in mice was lowered down by 84.48% as compared to the hyperuricemic control group. Based on the results obtained in this study, cinnamaldehyde may be a potential lead compound for developing the pharmaceutic for anti-hyperuricemia agent.

Authors+Show Affiliations

Department of Forestry, National Chung-Hsing University, Taichung 402, Taiwan. taiwanfir@dragon.nchu.edu.twNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18693097

Citation

Wang, S Y., et al. "Essential Oil From Leaves of Cinnamomum Osmophloeum Acts as a Xanthine Oxidase Inhibitor and Reduces the Serum Uric Acid Levels in Oxonate-induced Mice." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 15, no. 11, 2008, pp. 940-5.
Wang SY, Yang CW, Liao JW, et al. Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice. Phytomedicine. 2008;15(11):940-5.
Wang, S. Y., Yang, C. W., Liao, J. W., Zhen, W. W., Chu, F. H., & Chang, S. T. (2008). Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 15(11), 940-5. https://doi.org/10.1016/j.phymed.2008.06.002
Wang SY, et al. Essential Oil From Leaves of Cinnamomum Osmophloeum Acts as a Xanthine Oxidase Inhibitor and Reduces the Serum Uric Acid Levels in Oxonate-induced Mice. Phytomedicine. 2008;15(11):940-5. PubMed PMID: 18693097.
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TY - JOUR T1 - Essential oil from leaves of Cinnamomum osmophloeum acts as a xanthine oxidase inhibitor and reduces the serum uric acid levels in oxonate-induced mice. AU - Wang,S Y, AU - Yang,C W, AU - Liao,J W, AU - Zhen,W W, AU - Chu,F H, AU - Chang,S T, Y1 - 2008/08/06/ PY - 2008/8/12/entrez PY - 2008/8/12/pubmed PY - 2013/9/24/medline SP - 940 EP - 5 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 15 IS - 11 N2 - The xanthine oxidase (XOD) inhibitory activity and anti-hyperuricemia effect in mice of Cinnamomum osmophloeum, which is an endemic tree in Taiwan, were evaluated in this study. The results demonstrated that the essential oil of C. osmophloeum leaves presented the strongest XOD inhibition activity (IC(50)=16.3 μg/ml); however, no significant XOD inhibition activities were found in ethanolic and hot water extracts. Furthermore, among the main compounds of essential oil, the cinnamaldehyde exhibited the potent XOD inhibition activity with an IC(50)=8.4 μg/ml. Besides, the reducing serum uric acid levels in oxonate-induced mice by cinnamaldehyde were further investigated. The hyperuricemic mice were oral administrated cinnamaldehyde at a dosage of 150 mg/kg, the uric acid value in serum was reduced from 5.25±0.63 to 2.10±0.04 mg/dl, the levels of serum uric acid in mice was lowered down by 84.48% as compared to the hyperuricemic control group. Based on the results obtained in this study, cinnamaldehyde may be a potential lead compound for developing the pharmaceutic for anti-hyperuricemia agent. SN - 1618-095X UR - https://www.unboundmedicine.com/medline/citation/18693097/Essential_oil_from_leaves_of_Cinnamomum_osmophloeum_acts_as_a_xanthine_oxidase_inhibitor_and_reduces_the_serum_uric_acid_levels_in_oxonate_induced_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(08)00108-6 DB - PRIME DP - Unbound Medicine ER -