Nogueira, Daniele Rubert, et al. "Determination of Rupatadine in Pharmaceutical Formulations By a Validated Stability-indicating MEKC Method." Journal of Separation Science, vol. 31, no. 16-17, 2008, pp. 3098-105.
Nogueira DR, da Silva Sangoi M, da Silva LM, et al. Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method. J Sep Sci. 2008;31(16-17):3098-105.
Nogueira, D. R., da Silva Sangoi, M., da Silva, L. M., Todeschini, V., & Dalmora, S. L. (2008). Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method. Journal of Separation Science, 31(16-17), 3098-105. https://doi.org/10.1002/jssc.200800254
Nogueira DR, et al. Determination of Rupatadine in Pharmaceutical Formulations By a Validated Stability-indicating MEKC Method. J Sep Sci. 2008;31(16-17):3098-105. PubMed PMID: 18693320.
TY - JOUR
T1 - Determination of rupatadine in pharmaceutical formulations by a validated stability-indicating MEKC method.
AU - Nogueira,Daniele Rubert,
AU - da Silva Sangoi,Maximiliano,
AU - da Silva,Lucélia Magalhães,
AU - Todeschini,Vítor,
AU - Dalmora,Sérgio Luiz,
PY - 2008/8/12/pubmed
PY - 2008/12/20/medline
PY - 2008/8/12/entrez
SP - 3098
EP - 105
JF - Journal of separation science
JO - J Sep Sci
VL - 31
IS - 16-17
N2 - A stability-indicating MEKC was developed and validated for the analysis of rupatadine in tablet dosage forms, using nimesulide as internal standard. The MEKC method was performed on a fused-silica capillary (50 microm id; effective length, 40 cm). The BGE consisted of 15 mM borate buffer and 25 mM anionic detergent SDS solution at pH 10. The capillary temperature was maintained at 35 degrees C and the applied voltage was 25 kV. The injection was performed using the hydrodynamic mode at 50 mbar for 5 s, with detection by photodiode array detector set at 205 nm. The method was linear in the range of 0.5-150 microg/mL (r2=0.9996). The specificity and stability-indicating capability of the method were proven through degradation studies inclusive by MS, and showing also that there was no interference of the excipients and no increase of the cytotoxicity. The accuracy was 99.98% with bias lower than 1.06%. The LOD and LOQ were 0.1 and 0.5 microg/mL, respectively. The proposed method was successfully applied for the quantitative analysis of rupatadine in pharmaceutical formulations, and the results were compared to a validated RP-LC method, showing non-significant difference (p>0.05).
SN - 1615-9314
UR - https://www.unboundmedicine.com/medline/citation/18693320/Determination_of_rupatadine_in_pharmaceutical_formulations_by_a_validated_stability_indicating_MEKC_method_
L2 - https://doi.org/10.1002/jssc.200800254
DB - PRIME
DP - Unbound Medicine