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The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27.
Invest Ophthalmol Vis Sci. 1991 Aug; 32(9):2568-78.IO

Abstract

The lifetime cumulative incidence of acute anterior uveitis (AAU) was determined in a sample of a large population (n = 10,500). Nine hundred seventeen subjects, who answered the question "Have you ever had a red eye" in the affirmative in 1977, were asked to participate in a follow-up study 10 years later. From the 917 respondents, 539 were studied completely. A questionnaire was used to collect historic data, and confirmation of these data was obtained from the treating ophthalmologists and physicians. From these data, subjects were selected for an ophthalmologic examination. The respondents also underwent a rheumatologic examination. The results revealed that the lifetime cumulative incidence of definite AAU is approximately 0.2% in the general population and 1% in the histocompatibility antigen HLA-B27-positive population. In one third of the definite AAU patients, the cause of the disease was known. The lifetime cumulative incidence of definite AAU of unknown cause was 0.15% in the general population. When possible and probable AAU are included, the lifetime cumulative incidence of AAU in the general population is about 0.4%. The observed frequency of the concurrence of AAU and ankylosing spondylitis (AS) was 0.4% in the HLA-B27-positive population and 0.02% in the HLA-B27-negative population. Comparison with the expected frequency of the concurrence of AAU and AS revealed that AAU and AS probably are related diseases irrespective of the association of both diseases with HLA-B27.

Authors+Show Affiliations

Department of Ophthalmo-Immunology, The Netherlands Opthalmic Research Institute, Amsterdam.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

1869411

Citation

Linssen, A, et al. "The Lifetime Cumulative Incidence of Acute Anterior Uveitis in a Normal Population and Its Relation to Ankylosing Spondylitis and Histocompatibility Antigen HLA-B27." Investigative Ophthalmology & Visual Science, vol. 32, no. 9, 1991, pp. 2568-78.
Linssen A, Rothova A, Valkenburg HA, et al. The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. Invest Ophthalmol Vis Sci. 1991;32(9):2568-78.
Linssen, A., Rothova, A., Valkenburg, H. A., Dekker-Saeys, A. J., Luyendijk, L., Kijlstra, A., & Feltkamp, T. E. (1991). The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. Investigative Ophthalmology & Visual Science, 32(9), 2568-78.
Linssen A, et al. The Lifetime Cumulative Incidence of Acute Anterior Uveitis in a Normal Population and Its Relation to Ankylosing Spondylitis and Histocompatibility Antigen HLA-B27. Invest Ophthalmol Vis Sci. 1991;32(9):2568-78. PubMed PMID: 1869411.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The lifetime cumulative incidence of acute anterior uveitis in a normal population and its relation to ankylosing spondylitis and histocompatibility antigen HLA-B27. AU - Linssen,A, AU - Rothova,A, AU - Valkenburg,H A, AU - Dekker-Saeys,A J, AU - Luyendijk,L, AU - Kijlstra,A, AU - Feltkamp,T E, PY - 1991/8/1/pubmed PY - 1991/8/1/medline PY - 1991/8/1/entrez SP - 2568 EP - 78 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 32 IS - 9 N2 - The lifetime cumulative incidence of acute anterior uveitis (AAU) was determined in a sample of a large population (n = 10,500). Nine hundred seventeen subjects, who answered the question "Have you ever had a red eye" in the affirmative in 1977, were asked to participate in a follow-up study 10 years later. From the 917 respondents, 539 were studied completely. A questionnaire was used to collect historic data, and confirmation of these data was obtained from the treating ophthalmologists and physicians. From these data, subjects were selected for an ophthalmologic examination. The respondents also underwent a rheumatologic examination. The results revealed that the lifetime cumulative incidence of definite AAU is approximately 0.2% in the general population and 1% in the histocompatibility antigen HLA-B27-positive population. In one third of the definite AAU patients, the cause of the disease was known. The lifetime cumulative incidence of definite AAU of unknown cause was 0.15% in the general population. When possible and probable AAU are included, the lifetime cumulative incidence of AAU in the general population is about 0.4%. The observed frequency of the concurrence of AAU and ankylosing spondylitis (AS) was 0.4% in the HLA-B27-positive population and 0.02% in the HLA-B27-negative population. Comparison with the expected frequency of the concurrence of AAU and AS revealed that AAU and AS probably are related diseases irrespective of the association of both diseases with HLA-B27. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/1869411/The_lifetime_cumulative_incidence_of_acute_anterior_uveitis_in_a_normal_population_and_its_relation_to_ankylosing_spondylitis_and_histocompatibility_antigen_HLA_B27_ DB - PRIME DP - Unbound Medicine ER -