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Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion.
Epidemiol Infect. 2009 Apr; 137(4):534-41.EI

Abstract

In April 2005, an outbreak of Chikungunya fever occurred on the island of Réunion in the Indian Ocean. During winter 2005, six patients developed meningoencephalitis and acute hepatitis due to Chikungunya virus. Our objectives were to determine the incidence and mortality of atypical Chikungunya viral infections and to identify risk factors for severe disease. A hospital-based surveillance system was established to collect data on atypical Chikungunya cases. Case reports, medical records and laboratory results were reviewed and analysed. We defined an atypical case as one in which a patient with laboratory-confirmed Chikungunya virus infection developed symptoms other than fever and arthralgia. We defined a severe atypical case as one which required maintenance of at least one vital function. We recorded 610 atypical cases of Chikungunya fever: 222 were severe cases, 65 affected patients died. Five hundred and forty-six cases had underlying medical conditions (of which 226 suffered from cardiovascular, 147 from neurological and 150 from respiratory disorders). Clinical features that had never been associated with Chikungunya fever were recorded, such as bullous dermatosis, pneumonia, and diabetes mellitus. Hypertension, and underlying respiratory or cardiological conditions were independent risk factors for disease severity. The overall mortality rate was 10.6% and it increased with age. This is the first time that severe cases and deaths due to Chikungunya fever have been documented. The information presented in this article may assist clinicians in identifying the disease, selecting the treatment strategy, and anticipating the course of illness.

Authors+Show Affiliations

Institute de Veille Sanitaire, France. a_economopoulou@yahoo.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18694529

Citation

Economopoulou, A, et al. "Atypical Chikungunya Virus Infections: Clinical Manifestations, Mortality and Risk Factors for Severe Disease During the 2005-2006 Outbreak On Réunion." Epidemiology and Infection, vol. 137, no. 4, 2009, pp. 534-41.
Economopoulou A, Dominguez M, Helynck B, et al. Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion. Epidemiol Infect. 2009;137(4):534-41.
Economopoulou, A., Dominguez, M., Helynck, B., Sissoko, D., Wichmann, O., Quenel, P., Germonneau, P., & Quatresous, I. (2009). Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion. Epidemiology and Infection, 137(4), 534-41. https://doi.org/10.1017/S0950268808001167
Economopoulou A, et al. Atypical Chikungunya Virus Infections: Clinical Manifestations, Mortality and Risk Factors for Severe Disease During the 2005-2006 Outbreak On Réunion. Epidemiol Infect. 2009;137(4):534-41. PubMed PMID: 18694529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Atypical Chikungunya virus infections: clinical manifestations, mortality and risk factors for severe disease during the 2005-2006 outbreak on Réunion. AU - Economopoulou,A, AU - Dominguez,M, AU - Helynck,B, AU - Sissoko,D, AU - Wichmann,O, AU - Quenel,P, AU - Germonneau,P, AU - Quatresous,I, Y1 - 2008/08/11/ PY - 2008/8/13/pubmed PY - 2009/5/6/medline PY - 2008/8/13/entrez SP - 534 EP - 41 JF - Epidemiology and infection JO - Epidemiol Infect VL - 137 IS - 4 N2 - In April 2005, an outbreak of Chikungunya fever occurred on the island of Réunion in the Indian Ocean. During winter 2005, six patients developed meningoencephalitis and acute hepatitis due to Chikungunya virus. Our objectives were to determine the incidence and mortality of atypical Chikungunya viral infections and to identify risk factors for severe disease. A hospital-based surveillance system was established to collect data on atypical Chikungunya cases. Case reports, medical records and laboratory results were reviewed and analysed. We defined an atypical case as one in which a patient with laboratory-confirmed Chikungunya virus infection developed symptoms other than fever and arthralgia. We defined a severe atypical case as one which required maintenance of at least one vital function. We recorded 610 atypical cases of Chikungunya fever: 222 were severe cases, 65 affected patients died. Five hundred and forty-six cases had underlying medical conditions (of which 226 suffered from cardiovascular, 147 from neurological and 150 from respiratory disorders). Clinical features that had never been associated with Chikungunya fever were recorded, such as bullous dermatosis, pneumonia, and diabetes mellitus. Hypertension, and underlying respiratory or cardiological conditions were independent risk factors for disease severity. The overall mortality rate was 10.6% and it increased with age. This is the first time that severe cases and deaths due to Chikungunya fever have been documented. The information presented in this article may assist clinicians in identifying the disease, selecting the treatment strategy, and anticipating the course of illness. SN - 0950-2688 UR - https://www.unboundmedicine.com/medline/citation/18694529/Atypical_Chikungunya_virus_infections:_clinical_manifestations_mortality_and_risk_factors_for_severe_disease_during_the_2005_2006_outbreak_on_Réunion_ L2 - https://www.cambridge.org/core/product/identifier/S0950268808001167/type/journal_article DB - PRIME DP - Unbound Medicine ER -