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Serum folate is associated with coronary heart disease independently of homocysteine in Turkish men.
Clin Nutr. 2008 Oct; 27(5):732-9.CN

Abstract

BACKGROUND & AIMS

Whether serum homocysteine levels are associated with coronary heart disease (CHD) and the metabolic syndrome (MS) needs investigation in different ethnic groups. These associations and the influence of serum folate and vitamin B(12) thereupon were addressed separately in genders.

METHODS

A random sample of Turkish adults was studied cross-sectionally.

RESULTS

Median age of 338 men and 342 women was 55 years. Geometric mean serum homocysteine concentrations were 12.7+/-1.5 micromol/l in men and 9.6+/-1.4 micromol/l in women (p<0.001). Linear regression analysis among 11 variables revealed male sex, reduced estimated glomerular filtration rate (eGFR) and vitamin B(12), (in men) reduced folate as significant independent covariates of higher homocysteine levels. Logistic regression analysis disclosed that (sex-specific) top versus bottom homocysteine tertile was borderline significantly and independently associated with CHD in men and both genders combined, after adjustment for gender, age, smoking status, systolic blood pressure, eGFR, folate and vit B(12). Folate revealed significant inverse association with CHD likelihood in men and combined genders (OR 0.73 for doubling [95%CI 0.56; 0.94]), independently of homocysteine levels and even of presence of type-2 diabetes. Serum vit B(12) concentrations were significantly associated with MS likelihood in women alone after adjustment for sex, age, smoking status, folate and antidiabetic medication.

CONCLUSION

High serum homocysteine and low folate levels are associated in Turkish men independently with CHD, which needs confirmation in a larger sample. In women, vitamin B(12) concentrations are significantly associated with MS likelihood.

Authors+Show Affiliations

Turkish Society of Cardiology, Istanbul, Turkey; Cerrahpaşa Medical Faculty, Istanbul University, Istanbul, Turkey. alt_onat@yahoo.com.trNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18694616

Citation

Onat, Altan, et al. "Serum Folate Is Associated With Coronary Heart Disease Independently of Homocysteine in Turkish Men." Clinical Nutrition (Edinburgh, Scotland), vol. 27, no. 5, 2008, pp. 732-9.
Onat A, Hergenç G, Küçükdurmaz Z, et al. Serum folate is associated with coronary heart disease independently of homocysteine in Turkish men. Clin Nutr. 2008;27(5):732-9.
Onat, A., Hergenç, G., Küçükdurmaz, Z., Can, G., Ayhan, E., & Bulur, S. (2008). Serum folate is associated with coronary heart disease independently of homocysteine in Turkish men. Clinical Nutrition (Edinburgh, Scotland), 27(5), 732-9. https://doi.org/10.1016/j.clnu.2008.06.009
Onat A, et al. Serum Folate Is Associated With Coronary Heart Disease Independently of Homocysteine in Turkish Men. Clin Nutr. 2008;27(5):732-9. PubMed PMID: 18694616.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum folate is associated with coronary heart disease independently of homocysteine in Turkish men. AU - Onat,Altan, AU - Hergenç,Gülay, AU - Küçükdurmaz,Zekeriya, AU - Can,Günay, AU - Ayhan,Erkan, AU - Bulur,Serkan, Y1 - 2008/08/09/ PY - 2008/02/26/received PY - 2008/06/17/revised PY - 2008/06/24/accepted PY - 2008/8/13/pubmed PY - 2009/1/31/medline PY - 2008/8/13/entrez SP - 732 EP - 9 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 27 IS - 5 N2 - BACKGROUND & AIMS: Whether serum homocysteine levels are associated with coronary heart disease (CHD) and the metabolic syndrome (MS) needs investigation in different ethnic groups. These associations and the influence of serum folate and vitamin B(12) thereupon were addressed separately in genders. METHODS: A random sample of Turkish adults was studied cross-sectionally. RESULTS: Median age of 338 men and 342 women was 55 years. Geometric mean serum homocysteine concentrations were 12.7+/-1.5 micromol/l in men and 9.6+/-1.4 micromol/l in women (p<0.001). Linear regression analysis among 11 variables revealed male sex, reduced estimated glomerular filtration rate (eGFR) and vitamin B(12), (in men) reduced folate as significant independent covariates of higher homocysteine levels. Logistic regression analysis disclosed that (sex-specific) top versus bottom homocysteine tertile was borderline significantly and independently associated with CHD in men and both genders combined, after adjustment for gender, age, smoking status, systolic blood pressure, eGFR, folate and vit B(12). Folate revealed significant inverse association with CHD likelihood in men and combined genders (OR 0.73 for doubling [95%CI 0.56; 0.94]), independently of homocysteine levels and even of presence of type-2 diabetes. Serum vit B(12) concentrations were significantly associated with MS likelihood in women alone after adjustment for sex, age, smoking status, folate and antidiabetic medication. CONCLUSION: High serum homocysteine and low folate levels are associated in Turkish men independently with CHD, which needs confirmation in a larger sample. In women, vitamin B(12) concentrations are significantly associated with MS likelihood. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/18694616/Serum_folate_is_associated_with_coronary_heart_disease_independently_of_homocysteine_in_Turkish_men_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(08)00118-0 DB - PRIME DP - Unbound Medicine ER -