TY - JOUR T1 - Polysaccharides from Gracilaria corticata: sulfation, chemical characterization and anti-HSV activities. AU - Chattopadhyay,Kausik, AU - Ghosh,Tuhin, AU - Pujol,Carlos A, AU - Carlucci,María J, AU - Damonte,Elsa B, AU - Ray,Bimalendu, Y1 - 2008/07/23/ PY - 2008/06/15/received PY - 2008/07/09/revised PY - 2008/07/10/accepted PY - 2008/8/13/pubmed PY - 2008/12/17/medline PY - 2008/8/13/entrez SP - 346 EP - 51 JF - International journal of biological macromolecules JO - Int J Biol Macromol VL - 43 IS - 4 N2 - In this study, we have analyzed water-extracted polysaccharides of Gracilaria corticata. The water extract (WE), a galactan-containing sub-fraction (F3) and their hyper sulfated derivatives (WES1, WES2, F3S1 and F3S2) had anti-HSV activity with inhibitory concentration 50% (IC50) from 1.1 to 27.4 microg/ml. Sub-fraction F3, which has a molecular mass of 30 kDa, consists of a backbone of beta-(1-->3) and alpha-(1-->4)-linked-galactopyranosyl residues. This linear galactan contained Gal2Xyl1, Gal2AnGal2, Gal4 and Me-Gal3AnGal2 as oligomeric building subunits. Sulfate group was located at C-4 of (1-->3)-linked galactopyranosyl residues of the native galactan, and appeared to be very important for the anti-herpetic activity. SN - 0141-8130 UR - https://www.unboundmedicine.com/medline/citation/18694781/Polysaccharides_from_Gracilaria_corticata:_sulfation_chemical_characterization_and_anti_HSV_activities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0141-8130(08)00158-X DB - PRIME DP - Unbound Medicine ER -