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Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease.
Cell Mol Life Sci. 2008 Oct; 65(20):3265-89.CM

Abstract

The identification of the aspartic protease BACE1 (beta-secretase) was a defining event in research aimed at understanding the molecular mechanisms that underlie Alzheimer's disease (AD) pathogenesis. This is because BACE1 catalyses the rate limiting step in the production of amyloid-beta (Abeta) the principal component of plaque pathology in AD, the excessive production of which is believed to be a primary cause of neurodegeneration, and cognitive dysfunction in AD. Subsequent discoveries showed that genetic deletion of BACE1 completely abolishes Abeta production and deposition in vivo, and that BACE1 activity is significantly increased in AD brain. In this review we present current knowledge on BACE1, discussing its structure, function and complex regulation with a view to understanding BACE1 function in the brain, and BACE1 as a target in blocking aberrant Abeta production in AD.

Authors+Show Affiliations

Department of Biochemistry, BioSciences Institute University College Cork, Cork, Ireland.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18695942

Citation

Stockley, J H., and C O'Neill. "Understanding BACE1: Essential Protease for Amyloid-beta Production in Alzheimer's Disease." Cellular and Molecular Life Sciences : CMLS, vol. 65, no. 20, 2008, pp. 3265-89.
Stockley JH, O'Neill C. Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease. Cell Mol Life Sci. 2008;65(20):3265-89.
Stockley, J. H., & O'Neill, C. (2008). Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease. Cellular and Molecular Life Sciences : CMLS, 65(20), 3265-89. https://doi.org/10.1007/s00018-008-8271-3
Stockley JH, O'Neill C. Understanding BACE1: Essential Protease for Amyloid-beta Production in Alzheimer's Disease. Cell Mol Life Sci. 2008;65(20):3265-89. PubMed PMID: 18695942.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Understanding BACE1: essential protease for amyloid-beta production in Alzheimer's disease. AU - Stockley,J H, AU - O'Neill,C, PY - 2008/8/13/pubmed PY - 2008/12/17/medline PY - 2008/8/13/entrez SP - 3265 EP - 89 JF - Cellular and molecular life sciences : CMLS JO - Cell Mol Life Sci VL - 65 IS - 20 N2 - The identification of the aspartic protease BACE1 (beta-secretase) was a defining event in research aimed at understanding the molecular mechanisms that underlie Alzheimer's disease (AD) pathogenesis. This is because BACE1 catalyses the rate limiting step in the production of amyloid-beta (Abeta) the principal component of plaque pathology in AD, the excessive production of which is believed to be a primary cause of neurodegeneration, and cognitive dysfunction in AD. Subsequent discoveries showed that genetic deletion of BACE1 completely abolishes Abeta production and deposition in vivo, and that BACE1 activity is significantly increased in AD brain. In this review we present current knowledge on BACE1, discussing its structure, function and complex regulation with a view to understanding BACE1 function in the brain, and BACE1 as a target in blocking aberrant Abeta production in AD. SN - 1420-682X UR - https://www.unboundmedicine.com/medline/citation/18695942/Understanding_BACE1:_essential_protease_for_amyloid_beta_production_in_Alzheimer's_disease_ L2 - https://doi.org/10.1007/s00018-008-8271-3 DB - PRIME DP - Unbound Medicine ER -