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The nonlinear mechanical response of the red blood cell.
Phys Biol 2008; 5(3):036007PB

Abstract

We measure the dynamical mechanical properties of human red blood cells. A single cell response is measured with optical tweezers. We investigate both the stress relaxation following a fast deformation and the effect of varying the strain rate. We find a power-law decay of the stress as a function of time, down to a plateau stress, and a power-law increase of the cell's elasticity as a function of the strain rate. Interestingly, the exponents of these quantities violate the linear superposition principle, indicating a nonlinear response. We propose that this is due to the breaking of a fraction of the crosslinks during the deformation process. The soft glassy rheology model accounts for the relation between the exponents we observe experimentally. This picture is consistent with recent models of bond remodeling in the red blood cell's molecular structure. Our results imply that the blood cell's mechanical behavior depends critically on the deformation process.

Authors+Show Affiliations

Cavendish Laboratory and Nanoscience Center, University of Cambridge, Cambridge CB30HE, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18698116

Citation

Yoon, Young-Zoon, et al. "The Nonlinear Mechanical Response of the Red Blood Cell." Physical Biology, vol. 5, no. 3, 2008, p. 036007.
Yoon YZ, Kotar J, Yoon G, et al. The nonlinear mechanical response of the red blood cell. Phys Biol. 2008;5(3):036007.
Yoon, Y. Z., Kotar, J., Yoon, G., & Cicuta, P. (2008). The nonlinear mechanical response of the red blood cell. Physical Biology, 5(3), p. 036007. doi:10.1088/1478-3975/5/3/036007.
Yoon YZ, et al. The Nonlinear Mechanical Response of the Red Blood Cell. Phys Biol. 2008 Aug 13;5(3):036007. PubMed PMID: 18698116.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The nonlinear mechanical response of the red blood cell. AU - Yoon,Young-Zoon, AU - Kotar,Jurij, AU - Yoon,Gilwon, AU - Cicuta,Pietro, Y1 - 2008/08/13/ PY - 2008/8/14/pubmed PY - 2008/11/15/medline PY - 2008/8/14/entrez SP - 036007 EP - 036007 JF - Physical biology JO - Phys Biol VL - 5 IS - 3 N2 - We measure the dynamical mechanical properties of human red blood cells. A single cell response is measured with optical tweezers. We investigate both the stress relaxation following a fast deformation and the effect of varying the strain rate. We find a power-law decay of the stress as a function of time, down to a plateau stress, and a power-law increase of the cell's elasticity as a function of the strain rate. Interestingly, the exponents of these quantities violate the linear superposition principle, indicating a nonlinear response. We propose that this is due to the breaking of a fraction of the crosslinks during the deformation process. The soft glassy rheology model accounts for the relation between the exponents we observe experimentally. This picture is consistent with recent models of bond remodeling in the red blood cell's molecular structure. Our results imply that the blood cell's mechanical behavior depends critically on the deformation process. SN - 1478-3975 UR - https://www.unboundmedicine.com/medline/citation/18698116/The_nonlinear_mechanical_response_of_the_red_blood_cell_ L2 - https://doi.org/10.1088/1478-3975/5/3/036007 DB - PRIME DP - Unbound Medicine ER -