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Blood pressure and risk of type 2 diabetes mellitus in men and women from the general population: the Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Health Research in the Region of Augsburg Cohort Study.
J Hypertens. 2008 Sep; 26(9):1809-15.JH

Abstract

OBJECTIVE

To examine sex-specific associations between blood pressure levels and incident type 2 diabetes mellitus in a representative population sample in Germany.

METHODS

The study was based on 5556 men and 5445 women (aged 25-74 years) who participated in one of the three Monitoring Trends and Determinants on Cardiovascular Diseases Augsburg surveys between 1984 and 1995 and who were free of diabetes at baseline. Sex-specific hazard ratios were estimated from Cox proportional hazard models.

RESULTS

A total of 410 cases of incident type 2 diabetes among men and 263 among women were registered during the median follow-up period of 12.5 years. Higher blood pressure levels were associated with older age, higher body mass index (BMI), a higher prevalence of dyslipidemia, a lower prevalence of regular smoking, high alcohol consumption (men only), and a lower education level. Compared with individuals with normal blood pressure, the hazard ratios (95% confidence interval) of incident diabetes associated with an optimal blood pressure, high normal blood pressure, and hypertension were 0.67 (0.36-1.27), 1.76 (1.24-2.51), and 1.93 (1.41-2.65) for men and 0.74 (0.41-1.32), 1.07 (0.67-1.73), and 2.05 (1.41-2.99) for women. The found association was present in the subgroup with low BMI as well as in the group with high BMI supporting the assumption that blood pressure may contribute to the manifestation of type 2 diabetes independent of BMI.

CONCLUSION

Established hypertension was significantly associated with incident type 2 diabetes in men and women from the general population, whereas high normal blood pressure significantly increased the risk of diabetes in men only.

Authors+Show Affiliations

Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Institute of Epidemiology, Neuherberg, Germany. christa.meisinger@helmholtz-muenchen.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18698216

Citation

Meisinger, Christa, et al. "Blood Pressure and Risk of Type 2 Diabetes Mellitus in Men and Women From the General Population: the Monitoring Trends and Determinants On Cardiovascular Diseases/Cooperative Health Research in the Region of Augsburg Cohort Study." Journal of Hypertension, vol. 26, no. 9, 2008, pp. 1809-15.
Meisinger C, Döring A, Heier M. Blood pressure and risk of type 2 diabetes mellitus in men and women from the general population: the Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Health Research in the Region of Augsburg Cohort Study. J Hypertens. 2008;26(9):1809-15.
Meisinger, C., Döring, A., & Heier, M. (2008). Blood pressure and risk of type 2 diabetes mellitus in men and women from the general population: the Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Health Research in the Region of Augsburg Cohort Study. Journal of Hypertension, 26(9), 1809-15. https://doi.org/10.1097/HJH.0b013e328307c3e9
Meisinger C, Döring A, Heier M. Blood Pressure and Risk of Type 2 Diabetes Mellitus in Men and Women From the General Population: the Monitoring Trends and Determinants On Cardiovascular Diseases/Cooperative Health Research in the Region of Augsburg Cohort Study. J Hypertens. 2008;26(9):1809-15. PubMed PMID: 18698216.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Blood pressure and risk of type 2 diabetes mellitus in men and women from the general population: the Monitoring Trends and Determinants on Cardiovascular Diseases/Cooperative Health Research in the Region of Augsburg Cohort Study. AU - Meisinger,Christa, AU - Döring,Angela, AU - Heier,Margit, PY - 2008/8/14/pubmed PY - 2008/12/20/medline PY - 2008/8/14/entrez SP - 1809 EP - 15 JF - Journal of hypertension JO - J Hypertens VL - 26 IS - 9 N2 - OBJECTIVE: To examine sex-specific associations between blood pressure levels and incident type 2 diabetes mellitus in a representative population sample in Germany. METHODS: The study was based on 5556 men and 5445 women (aged 25-74 years) who participated in one of the three Monitoring Trends and Determinants on Cardiovascular Diseases Augsburg surveys between 1984 and 1995 and who were free of diabetes at baseline. Sex-specific hazard ratios were estimated from Cox proportional hazard models. RESULTS: A total of 410 cases of incident type 2 diabetes among men and 263 among women were registered during the median follow-up period of 12.5 years. Higher blood pressure levels were associated with older age, higher body mass index (BMI), a higher prevalence of dyslipidemia, a lower prevalence of regular smoking, high alcohol consumption (men only), and a lower education level. Compared with individuals with normal blood pressure, the hazard ratios (95% confidence interval) of incident diabetes associated with an optimal blood pressure, high normal blood pressure, and hypertension were 0.67 (0.36-1.27), 1.76 (1.24-2.51), and 1.93 (1.41-2.65) for men and 0.74 (0.41-1.32), 1.07 (0.67-1.73), and 2.05 (1.41-2.99) for women. The found association was present in the subgroup with low BMI as well as in the group with high BMI supporting the assumption that blood pressure may contribute to the manifestation of type 2 diabetes independent of BMI. CONCLUSION: Established hypertension was significantly associated with incident type 2 diabetes in men and women from the general population, whereas high normal blood pressure significantly increased the risk of diabetes in men only. SN - 0263-6352 UR - https://www.unboundmedicine.com/medline/citation/18698216/Blood_pressure_and_risk_of_type_2_diabetes_mellitus_in_men_and_women_from_the_general_population:_the_Monitoring_Trends_and_Determinants_on_Cardiovascular_Diseases/Cooperative_Health_Research_in_the_Region_of_Augsburg_Cohort_Study_ L2 - https://doi.org/10.1097/HJH.0b013e328307c3e9 DB - PRIME DP - Unbound Medicine ER -