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Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes.
Retina 2008 Jul-Aug; 28(7):969-75R

Abstract

PURPOSE

To examine the relationship between visual acuity and morphologic characteristics of macular holes as determined using spectral domain optical coherence tomography (SD OCT).

METHODS

A retrospective analysis was performed of eyes with open and closed macular holes at a single, referral-based retina practice. The main outcome measures included best-corrected Snellen visual acuity and SD OCT findings, including the size of the macular hole and the disruption of the junction between inner segments (ISs) and outer segments (OSs) of the photoreceptors.

RESULTS

The mean visual acuity for eyes with open (n = 24) and closed (n = 17) macular holes was 20/166 (range, 5/400 to 20/40) and 20/39 (range, 20/80 to 20/25), respectively. The mean macular hole diameter was 859 microm. A disruption of the IS-OS junction was observed in all eyes, and this disruption had a mean diameter of 1,947 microm in eyes with an open macular hole and 626 microm in those with a closed macular hole. There was a negative correlation between both the size of the macular hole (P < 0.001) and the IS-OS disruption (P = 0.01) and visual acuity in eyes with open macular holes. In eyes with closed macular hole, the size of the IS-OS disruption was not correlated with visual acuity (P = 0.82).

CONCLUSIONS

The photoreceptor layer appears to be involved for a much larger area than that occupied by the macular hole itself. The abnormality in the IS-OS boundary line may reflect perturbation of a higher level of retinal organization and not an absolute loss of photoreceptor OSs.

Authors+Show Affiliations

Vitreous, Retina, Macula Consultants of New York, and the LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear, and Throat Hospital, New York, New York, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18698299

Citation

Chang, Louis K., et al. "Disruption of the Photoreceptor Inner Segment-outer Segment Junction in Eyes With Macular Holes." Retina (Philadelphia, Pa.), vol. 28, no. 7, 2008, pp. 969-75.
Chang LK, Koizumi H, Spaide RF. Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes. Retina (Philadelphia, Pa). 2008;28(7):969-75.
Chang, L. K., Koizumi, H., & Spaide, R. F. (2008). Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes. Retina (Philadelphia, Pa.), 28(7), pp. 969-75. doi:10.1097/IAE.0b013e3181744165.
Chang LK, Koizumi H, Spaide RF. Disruption of the Photoreceptor Inner Segment-outer Segment Junction in Eyes With Macular Holes. Retina (Philadelphia, Pa). 2008;28(7):969-75. PubMed PMID: 18698299.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disruption of the photoreceptor inner segment-outer segment junction in eyes with macular holes. AU - Chang,Louis K, AU - Koizumi,Hideki, AU - Spaide,Richard F, PY - 2008/8/14/pubmed PY - 2008/8/30/medline PY - 2008/8/14/entrez SP - 969 EP - 75 JF - Retina (Philadelphia, Pa.) JO - Retina (Philadelphia, Pa.) VL - 28 IS - 7 N2 - PURPOSE: To examine the relationship between visual acuity and morphologic characteristics of macular holes as determined using spectral domain optical coherence tomography (SD OCT). METHODS: A retrospective analysis was performed of eyes with open and closed macular holes at a single, referral-based retina practice. The main outcome measures included best-corrected Snellen visual acuity and SD OCT findings, including the size of the macular hole and the disruption of the junction between inner segments (ISs) and outer segments (OSs) of the photoreceptors. RESULTS: The mean visual acuity for eyes with open (n = 24) and closed (n = 17) macular holes was 20/166 (range, 5/400 to 20/40) and 20/39 (range, 20/80 to 20/25), respectively. The mean macular hole diameter was 859 microm. A disruption of the IS-OS junction was observed in all eyes, and this disruption had a mean diameter of 1,947 microm in eyes with an open macular hole and 626 microm in those with a closed macular hole. There was a negative correlation between both the size of the macular hole (P < 0.001) and the IS-OS disruption (P = 0.01) and visual acuity in eyes with open macular holes. In eyes with closed macular hole, the size of the IS-OS disruption was not correlated with visual acuity (P = 0.82). CONCLUSIONS: The photoreceptor layer appears to be involved for a much larger area than that occupied by the macular hole itself. The abnormality in the IS-OS boundary line may reflect perturbation of a higher level of retinal organization and not an absolute loss of photoreceptor OSs. SN - 0275-004X UR - https://www.unboundmedicine.com/medline/citation/18698299/Disruption_of_the_photoreceptor_inner_segment_outer_segment_junction_in_eyes_with_macular_holes_ L2 - http://dx.doi.org/10.1097/IAE.0b013e3181744165 DB - PRIME DP - Unbound Medicine ER -