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Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide).
Langmuir 2008; 24(18):10099-106L

Abstract

A novel biodegradable diblock copolymer, poly(L-cysteine)-b-poly(L-lactide) (PLC-b-PLLA), was synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of beta-benzyloxycarbonyl-L-cysteine (ZLC-NCA) with amino-terminated poly(L-lactide) (NH 2-PLLA) as a macroinitiator in a convenient way. The diblock copolymer and its precursor were characterized by (1)H NMR, Fourier transform infrared (FT-IR), gel permeation chromatography (GPC), and X-ray photoelectron spectroscopy (XPS) measurements. The length of each block polymer could be tailored by molecular design and the ratios of feeding monomers. The cell adhesion and cell spread on the PZLC-b-PLLA and PLC-b-PLLA films were enhanced compared to those on pure PLA film. PLC-b-PLLA can self-assemble to form micelles in aqueous media. A pyrene probe is used to demonstrate the micelle formation of PLC-b-PLLA in aqueous solution. Due to the ease of disulfide exchange with thiols, the obtained micelles are reversible shell cross-linked (SCL) micelles. The morphology and size of the micelles are studied by dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM).

Authors+Show Affiliations

Changchun Institute of Applied Chemistry, State Key Laboratory of Polymer Physics and Chemistry, Chinese Academy of Sciences, Changchun, P. R. China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18698858

Citation

Sun, Jing, et al. "Formation of Reversible Shell Cross-linked Micelles From the Biodegradable Amphiphilic Diblock Copolymer Poly(L-cysteine)-block-poly(L-lactide)." Langmuir : the ACS Journal of Surfaces and Colloids, vol. 24, no. 18, 2008, pp. 10099-106.
Sun J, Chen X, Lu T, et al. Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide). Langmuir. 2008;24(18):10099-106.
Sun, J., Chen, X., Lu, T., Liu, S., Tian, H., Guo, Z., & Jing, X. (2008). Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide). Langmuir : the ACS Journal of Surfaces and Colloids, 24(18), pp. 10099-106. doi:10.1021/la8013877.
Sun J, et al. Formation of Reversible Shell Cross-linked Micelles From the Biodegradable Amphiphilic Diblock Copolymer Poly(L-cysteine)-block-poly(L-lactide). Langmuir. 2008 Sep 16;24(18):10099-106. PubMed PMID: 18698858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Formation of reversible shell cross-linked micelles from the biodegradable amphiphilic diblock copolymer poly(L-cysteine)-block-poly(L-lactide). AU - Sun,Jing, AU - Chen,Xuesi, AU - Lu,Tiancheng, AU - Liu,Shi, AU - Tian,Huayu, AU - Guo,Zhaopei, AU - Jing,Xiabin, Y1 - 2008/08/13/ PY - 2008/8/14/pubmed PY - 2008/10/18/medline PY - 2008/8/14/entrez SP - 10099 EP - 106 JF - Langmuir : the ACS journal of surfaces and colloids JO - Langmuir VL - 24 IS - 18 N2 - A novel biodegradable diblock copolymer, poly(L-cysteine)-b-poly(L-lactide) (PLC-b-PLLA), was synthesized by ring-opening polymerization (ROP) of N-carboxyanhydride of beta-benzyloxycarbonyl-L-cysteine (ZLC-NCA) with amino-terminated poly(L-lactide) (NH 2-PLLA) as a macroinitiator in a convenient way. The diblock copolymer and its precursor were characterized by (1)H NMR, Fourier transform infrared (FT-IR), gel permeation chromatography (GPC), and X-ray photoelectron spectroscopy (XPS) measurements. The length of each block polymer could be tailored by molecular design and the ratios of feeding monomers. The cell adhesion and cell spread on the PZLC-b-PLLA and PLC-b-PLLA films were enhanced compared to those on pure PLA film. PLC-b-PLLA can self-assemble to form micelles in aqueous media. A pyrene probe is used to demonstrate the micelle formation of PLC-b-PLLA in aqueous solution. Due to the ease of disulfide exchange with thiols, the obtained micelles are reversible shell cross-linked (SCL) micelles. The morphology and size of the micelles are studied by dynamic light scattering (DLS) and environmental scanning electron microscopy (ESEM). SN - 0743-7463 UR - https://www.unboundmedicine.com/medline/citation/18698858/Formation_of_reversible_shell_cross_linked_micelles_from_the_biodegradable_amphiphilic_diblock_copolymer_poly_L_cysteine__block_poly_L_lactide__ L2 - https://dx.doi.org/10.1021/la8013877 DB - PRIME DP - Unbound Medicine ER -