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Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity.
BMC Pediatr. 2008 Aug 12; 8:31.BPed

Abstract

BACKGROUND

Obesity is a one of the most common nutritional disorder worldwide, clearly associated with the metabolic syndrome, condition with implications for the development of many chronic diseases. In the poorest countries of Latin America, malnourishment is still the most prevalent nutritional problem, but obesity is emerging in alarming rates over the last 10 years without a predictable association with metabolic syndrome. The objective of our study was to determine the association between insulin-resistance and components of the metabolic syndrome in a group of Bolivian obese children and adolescents. The second objective was determining the relation of acanthosis nigricans and insulin-resistance.

METHODS

We studied 61 obese children and adolescents aged between 5 and 18 years old. All children underwent an oral glucose tolerance test and fasting blood sample was also obtained to measure insulin, HDL, LDL and triglycerides serum level. The diagnosis of metabolic syndrome was defined according to National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP III) criteria adapted for children.

RESULTS

Metabolic syndrome was found in 36% of the children, with a higher rate among males (40%) than females (32.2%) (p = 0.599). The prevalence of each of the components was 8.2% in impaired glucose tolerance, 42.6% for high triglyceride level, 55.7% for low levels of high-density lipoprotein cholesterol, and 24.5% for high blood pressure. Insulin resistance (HOMA-IR > 3.5) was found in 39.4% of the children, with a higher rate in males (50%) than females (29%). A strong correlation was found between insulin resistance and high blood pressure (p = 0.0148) and high triglycerides (p = 0.002). No statistical significance was found between the presence of acanthosis nigricans and insulin resistance.

CONCLUSION

Metabolic syndrome has a prevalence of 36% in children and adolescent population in the study. Insulin resistance was very common among children with obesity with a significant association with high blood pressure and high triglycerides presence.

Authors+Show Affiliations

Department of General Pediatrics, Centro Pediatrico Albina Patiño, Cochabamba, Bolivia. margothcm@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18700035

Citation

Caceres, Margoth, et al. "Prevalence of Insulin Resistance and Its Association With Metabolic Syndrome Criteria Among Bolivian Children and Adolescents With Obesity." BMC Pediatrics, vol. 8, 2008, p. 31.
Caceres M, Teran CG, Rodriguez S, et al. Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity. BMC Pediatr. 2008;8:31.
Caceres, M., Teran, C. G., Rodriguez, S., & Medina, M. (2008). Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity. BMC Pediatrics, 8, 31. https://doi.org/10.1186/1471-2431-8-31
Caceres M, et al. Prevalence of Insulin Resistance and Its Association With Metabolic Syndrome Criteria Among Bolivian Children and Adolescents With Obesity. BMC Pediatr. 2008 Aug 12;8:31. PubMed PMID: 18700035.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of insulin resistance and its association with metabolic syndrome criteria among Bolivian children and adolescents with obesity. AU - Caceres,Margoth, AU - Teran,C G, AU - Rodriguez,Susana, AU - Medina,Marcos, Y1 - 2008/08/12/ PY - 2008/04/12/received PY - 2008/08/12/accepted PY - 2008/8/14/pubmed PY - 2008/10/22/medline PY - 2008/8/14/entrez SP - 31 EP - 31 JF - BMC pediatrics JO - BMC Pediatr VL - 8 N2 - BACKGROUND: Obesity is a one of the most common nutritional disorder worldwide, clearly associated with the metabolic syndrome, condition with implications for the development of many chronic diseases. In the poorest countries of Latin America, malnourishment is still the most prevalent nutritional problem, but obesity is emerging in alarming rates over the last 10 years without a predictable association with metabolic syndrome. The objective of our study was to determine the association between insulin-resistance and components of the metabolic syndrome in a group of Bolivian obese children and adolescents. The second objective was determining the relation of acanthosis nigricans and insulin-resistance. METHODS: We studied 61 obese children and adolescents aged between 5 and 18 years old. All children underwent an oral glucose tolerance test and fasting blood sample was also obtained to measure insulin, HDL, LDL and triglycerides serum level. The diagnosis of metabolic syndrome was defined according to National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP III) criteria adapted for children. RESULTS: Metabolic syndrome was found in 36% of the children, with a higher rate among males (40%) than females (32.2%) (p = 0.599). The prevalence of each of the components was 8.2% in impaired glucose tolerance, 42.6% for high triglyceride level, 55.7% for low levels of high-density lipoprotein cholesterol, and 24.5% for high blood pressure. Insulin resistance (HOMA-IR > 3.5) was found in 39.4% of the children, with a higher rate in males (50%) than females (29%). A strong correlation was found between insulin resistance and high blood pressure (p = 0.0148) and high triglycerides (p = 0.002). No statistical significance was found between the presence of acanthosis nigricans and insulin resistance. CONCLUSION: Metabolic syndrome has a prevalence of 36% in children and adolescent population in the study. Insulin resistance was very common among children with obesity with a significant association with high blood pressure and high triglycerides presence. SN - 1471-2431 UR - https://www.unboundmedicine.com/medline/citation/18700035/Prevalence_of_insulin_resistance_and_its_association_with_metabolic_syndrome_criteria_among_Bolivian_children_and_adolescents_with_obesity_ L2 - https://bmcpediatr.biomedcentral.com/articles/10.1186/1471-2431-8-31 DB - PRIME DP - Unbound Medicine ER -