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The H1 histamine receptor blocker, chlorpheniramine, completely prevents the increase in REM sleep induced by immobilization stress in rats.
Pharmacol Biochem Behav. 2009 Jan; 91(3):291-4.PB

Abstract

Chlorpheniramine is a selective antagonist of the H1 histaminergic receptor subtype and its effects in humans include somnolence. Chlorpheniramine affects sleep in rats, mainly by decreasing REM sleep. On the other hand, stress by immobilization induces an important increase in the percentage of REM sleep. In this study we analyzed the effects of blocking histaminergic receptors on REM sleep induced by immobilization stress. Adult male Wistar rats were chronically implanted for sleep recording. Immobilization stress was induced by placing the rat in a small cylinder for 2 h. Experimental conditions were: A. Control; B. Stress; C. Stress plus vehicle and D. Stress plus chlorpheniramine. Independent experiments were done both in the dark, as well as the light period. Results showed that the increase in REM sleep observed after immobilization stress was completely abolished by chlorpheniramine, both in the dark and in the light phase. Furthermore, the decrease in REM sleep was significant even when compared to the non-stressed control rats. REM sleep latency was also significantly longer during both light phases. The present results suggest that REM sleep is quite sensitive to histaminergic blockage. It is possible that chlorpheniramine is also blocking the cholinergic mechanisms generating REM sleep.

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Authors+Show Affiliations

Rojas-Zamorano JA
Department of Biology of Reproduction, Universidad Autonoma Metropolitana-Iztapalapa, CP 09340, Mexico City, Mexico.
Esqueda-Leon E
No affiliation info available
Jimenez-Anguiano A
No affiliation info available
Cintra-McGlone L
No affiliation info available
Mendoza Melendez MA
No affiliation info available
Velazquez Moctezuma J
No affiliation info available

MeSH

AnimalsChlorpheniramineDarknessElectroencephalographyElectromyographyHistamine H1 AntagonistsLightMalePolysomnographyRatsRats, WistarRestraint, PhysicalSleep, REMStress, Psychological

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18700151

Citation

Rojas-Zamorano, J A., et al. "The H1 Histamine Receptor Blocker, Chlorpheniramine, Completely Prevents the Increase in REM Sleep Induced By Immobilization Stress in Rats." Pharmacology, Biochemistry, and Behavior, vol. 91, no. 3, 2009, pp. 291-4.
Rojas-Zamorano JA, Esqueda-Leon E, Jimenez-Anguiano A, et al. The H1 histamine receptor blocker, chlorpheniramine, completely prevents the increase in REM sleep induced by immobilization stress in rats. Pharmacol Biochem Behav. 2009;91(3):291-4.
Rojas-Zamorano, J. A., Esqueda-Leon, E., Jimenez-Anguiano, A., Cintra-McGlone, L., Mendoza Melendez, M. A., & Velazquez Moctezuma, J. (2009). The H1 histamine receptor blocker, chlorpheniramine, completely prevents the increase in REM sleep induced by immobilization stress in rats. Pharmacology, Biochemistry, and Behavior, 91(3), 291-4. https://doi.org/10.1016/j.pbb.2008.07.011
Rojas-Zamorano JA, et al. The H1 Histamine Receptor Blocker, Chlorpheniramine, Completely Prevents the Increase in REM Sleep Induced By Immobilization Stress in Rats. Pharmacol Biochem Behav. 2009;91(3):291-4. PubMed PMID: 18700151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The H1 histamine receptor blocker, chlorpheniramine, completely prevents the increase in REM sleep induced by immobilization stress in rats. AU - Rojas-Zamorano,J A, AU - Esqueda-Leon,E, AU - Jimenez-Anguiano,A, AU - Cintra-McGlone,L, AU - Mendoza Melendez,M A, AU - Velazquez Moctezuma,J, Y1 - 2008/07/22/ PY - 2008/04/10/received PY - 2008/07/08/revised PY - 2008/07/16/accepted PY - 2008/8/14/pubmed PY - 2009/4/3/medline PY - 2008/8/14/entrez SP - 291 EP - 4 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 91 IS - 3 N2 - Chlorpheniramine is a selective antagonist of the H1 histaminergic receptor subtype and its effects in humans include somnolence. Chlorpheniramine affects sleep in rats, mainly by decreasing REM sleep. On the other hand, stress by immobilization induces an important increase in the percentage of REM sleep. In this study we analyzed the effects of blocking histaminergic receptors on REM sleep induced by immobilization stress. Adult male Wistar rats were chronically implanted for sleep recording. Immobilization stress was induced by placing the rat in a small cylinder for 2 h. Experimental conditions were: A. Control; B. Stress; C. Stress plus vehicle and D. Stress plus chlorpheniramine. Independent experiments were done both in the dark, as well as the light period. Results showed that the increase in REM sleep observed after immobilization stress was completely abolished by chlorpheniramine, both in the dark and in the light phase. Furthermore, the decrease in REM sleep was significant even when compared to the non-stressed control rats. REM sleep latency was also significantly longer during both light phases. The present results suggest that REM sleep is quite sensitive to histaminergic blockage. It is possible that chlorpheniramine is also blocking the cholinergic mechanisms generating REM sleep. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/18700151/The_H1_histamine_receptor_blocker_chlorpheniramine_completely_prevents_the_increase_in_REM_sleep_induced_by_immobilization_stress_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(08)00267-0 DB - PRIME DP - Unbound Medicine ER -