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Small intestine bacterial overgrowth in patients with irritable bowel syndrome.
Eur Rev Med Pharmacol Sci 2008 May-Jun; 12(3):197-202ER

Abstract

Recent investigations in patients with irritable bowel syndrome (IBS) undergoing a breath test (BT) with lactulose, have shown inconclusive results on a possible association between IBS and a small intestine bacterial overgrowth (SIBO), as well as on the effective prevalence of SIBO in IBS patients, because of different geographic areas involved and different criteria adopted for the BT positivity. The aim of this study was to estimate the prevalence of SIBO among IBS patients by means a lactulose BT. Between January 2005 and December 2006, all the patients who were sent to our Gastroenterology Unit by general practitioners (GPs) for "functional" gastrointestinal (GI) symptoms, underwent a lactulose BT for diagnosis of SIBO. The test was considered positive if the hydrogen concentrations in the expired air increased more than 20 ppm over basal values within 90 minutes. A total of 127 patients have been selected, 28 males and 99 females, aged between 17 and 76 (mean age: 41.4 years), with an IBS diagnosis based on the Roma II criteria. Fifty-five patients (43%) resulted positive to the lactulose BT. No significant difference was observed between IBS patients with (SIBO+) and without (SIBO-) an intestinal bacteria contamination. In conclusion, our results indicate that SIBO is relatively frequent in IBS patients and that execution of a lactulose BT should be encouraged in all these patients, being the only way to make correct diagnosis of SIBO and establish a valid therapeutic treatment.

Authors+Show Affiliations

Department of Gastroenterology, Ospedale Orlandi, Bussolengo, Verona, Italy. mcarrara@ulss22.ven.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18700692

Citation

Carrara, M, et al. "Small Intestine Bacterial Overgrowth in Patients With Irritable Bowel Syndrome." European Review for Medical and Pharmacological Sciences, vol. 12, no. 3, 2008, pp. 197-202.
Carrara M, Desideri S, Azzurro M, et al. Small intestine bacterial overgrowth in patients with irritable bowel syndrome. Eur Rev Med Pharmacol Sci. 2008;12(3):197-202.
Carrara, M., Desideri, S., Azzurro, M., Bulighin, G. M., Di Piramo, D., Lomonaco, L., & Adamo, S. (2008). Small intestine bacterial overgrowth in patients with irritable bowel syndrome. European Review for Medical and Pharmacological Sciences, 12(3), pp. 197-202.
Carrara M, et al. Small Intestine Bacterial Overgrowth in Patients With Irritable Bowel Syndrome. Eur Rev Med Pharmacol Sci. 2008;12(3):197-202. PubMed PMID: 18700692.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small intestine bacterial overgrowth in patients with irritable bowel syndrome. AU - Carrara,M, AU - Desideri,S, AU - Azzurro,M, AU - Bulighin,G M, AU - Di Piramo,D, AU - Lomonaco,L, AU - Adamo,S, PY - 2008/8/15/pubmed PY - 2008/9/17/medline PY - 2008/8/15/entrez SP - 197 EP - 202 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 12 IS - 3 N2 - Recent investigations in patients with irritable bowel syndrome (IBS) undergoing a breath test (BT) with lactulose, have shown inconclusive results on a possible association between IBS and a small intestine bacterial overgrowth (SIBO), as well as on the effective prevalence of SIBO in IBS patients, because of different geographic areas involved and different criteria adopted for the BT positivity. The aim of this study was to estimate the prevalence of SIBO among IBS patients by means a lactulose BT. Between January 2005 and December 2006, all the patients who were sent to our Gastroenterology Unit by general practitioners (GPs) for "functional" gastrointestinal (GI) symptoms, underwent a lactulose BT for diagnosis of SIBO. The test was considered positive if the hydrogen concentrations in the expired air increased more than 20 ppm over basal values within 90 minutes. A total of 127 patients have been selected, 28 males and 99 females, aged between 17 and 76 (mean age: 41.4 years), with an IBS diagnosis based on the Roma II criteria. Fifty-five patients (43%) resulted positive to the lactulose BT. No significant difference was observed between IBS patients with (SIBO+) and without (SIBO-) an intestinal bacteria contamination. In conclusion, our results indicate that SIBO is relatively frequent in IBS patients and that execution of a lactulose BT should be encouraged in all these patients, being the only way to make correct diagnosis of SIBO and establish a valid therapeutic treatment. SN - 1128-3602 UR - https://www.unboundmedicine.com/medline/citation/18700692/Small_intestine_bacterial_overgrowth_in_patients_with_irritable_bowel_syndrome_ L2 - http://www.diseaseinfosearch.org/result/3876 DB - PRIME DP - Unbound Medicine ER -