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Screening for bipolar disorder in a Spanish sample of outpatients with current major depressive episode.
J Affect Disord. 2009 Apr; 114(1-3):299-304.JA

Abstract

OBJECTIVE

Bipolar spectrum disorders often go unrecognised and undiagnosed or misdiagnosed. One of the underlying reasons is the poor recognition of bipolar disorder among patients presenting depressive episodes. The specific aim of this study was to estimate the Mood Disorder Questionnaire (MDQ) rate of positive screens for bipolar disorder in a Spanish sample of outpatients with a current major depressive episode and compare it with their current psychiatric diagnosis. The study was designed to address this specific question.

METHOD

971 consecutively outpatients with a current DSM-IV TR diagnosis of a major depressive episode entered this cross-sectional study. Study measures included sociodemographic and clinical data, Clinical Global Impression of Severity of Illness Scale (CGI-S), Hamilton Depression Scale (HAMD) and MDQ.

RESULTS

905 patients fulfilled criteria to be included in the analysis. All of them presented with a current major depressive episode. 74.3% (n=671) of the patients had received a diagnosis of unipolar depression and 25.7% (n=232) of bipolar disorder by a psychiatrist. Using a MDQ of 7-or-more-item threshold, the global positive screen rate for bipolar disorder was 41.3% (n=373). From the 671 patients with previous unipolar depression diagnosis, 161 (24%) screened positive for bipolar disorder with MDQ, whereas in 232 patients diagnosed of bipolar disorder, 212 (91.4%) screened positive for bipolar disorder.

CONCLUSIONS

The MDQ showed a positive screen rate for bipolar disorder in 24% of patients with a previous diagnosis of unipolar disorder and a current major depressive episode. Screening tools like MDQ could contribute to increase detection of bipolar disorder in patients with depression. Early diagnosis of bipolar disorder may have important clinical and therapeutic implications in order to improve the illness course and the long-term functional outcome.

Authors+Show Affiliations

Medical Department, AstraZeneca, Madrid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18701169

Citation

Tafalla, M, et al. "Screening for Bipolar Disorder in a Spanish Sample of Outpatients With Current Major Depressive Episode." Journal of Affective Disorders, vol. 114, no. 1-3, 2009, pp. 299-304.
Tafalla M, Sanchez-Moreno J, Diez T, et al. Screening for bipolar disorder in a Spanish sample of outpatients with current major depressive episode. J Affect Disord. 2009;114(1-3):299-304.
Tafalla, M., Sanchez-Moreno, J., Diez, T., & Vieta, E. (2009). Screening for bipolar disorder in a Spanish sample of outpatients with current major depressive episode. Journal of Affective Disorders, 114(1-3), 299-304. https://doi.org/10.1016/j.jad.2008.06.025
Tafalla M, et al. Screening for Bipolar Disorder in a Spanish Sample of Outpatients With Current Major Depressive Episode. J Affect Disord. 2009;114(1-3):299-304. PubMed PMID: 18701169.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening for bipolar disorder in a Spanish sample of outpatients with current major depressive episode. AU - Tafalla,M, AU - Sanchez-Moreno,J, AU - Diez,T, AU - Vieta,E, Y1 - 2008/08/13/ PY - 2008/04/30/received PY - 2008/06/27/revised PY - 2008/06/28/accepted PY - 2008/8/15/pubmed PY - 2009/7/23/medline PY - 2008/8/15/entrez SP - 299 EP - 304 JF - Journal of affective disorders JO - J Affect Disord VL - 114 IS - 1-3 N2 - OBJECTIVE: Bipolar spectrum disorders often go unrecognised and undiagnosed or misdiagnosed. One of the underlying reasons is the poor recognition of bipolar disorder among patients presenting depressive episodes. The specific aim of this study was to estimate the Mood Disorder Questionnaire (MDQ) rate of positive screens for bipolar disorder in a Spanish sample of outpatients with a current major depressive episode and compare it with their current psychiatric diagnosis. The study was designed to address this specific question. METHOD: 971 consecutively outpatients with a current DSM-IV TR diagnosis of a major depressive episode entered this cross-sectional study. Study measures included sociodemographic and clinical data, Clinical Global Impression of Severity of Illness Scale (CGI-S), Hamilton Depression Scale (HAMD) and MDQ. RESULTS: 905 patients fulfilled criteria to be included in the analysis. All of them presented with a current major depressive episode. 74.3% (n=671) of the patients had received a diagnosis of unipolar depression and 25.7% (n=232) of bipolar disorder by a psychiatrist. Using a MDQ of 7-or-more-item threshold, the global positive screen rate for bipolar disorder was 41.3% (n=373). From the 671 patients with previous unipolar depression diagnosis, 161 (24%) screened positive for bipolar disorder with MDQ, whereas in 232 patients diagnosed of bipolar disorder, 212 (91.4%) screened positive for bipolar disorder. CONCLUSIONS: The MDQ showed a positive screen rate for bipolar disorder in 24% of patients with a previous diagnosis of unipolar disorder and a current major depressive episode. Screening tools like MDQ could contribute to increase detection of bipolar disorder in patients with depression. Early diagnosis of bipolar disorder may have important clinical and therapeutic implications in order to improve the illness course and the long-term functional outcome. SN - 1573-2517 UR - https://www.unboundmedicine.com/medline/citation/18701169/Screening_for_bipolar_disorder_in_a_Spanish_sample_of_outpatients_with_current_major_depressive_episode_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-0327(08)00281-4 DB - PRIME DP - Unbound Medicine ER -