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Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on weight loss and insulin levels secondary to two hypocaloric diets: a randomized clinical trial.
Diabetes Res Clin Pract. 2008 Oct; 82(1):113-8.DR

Abstract

OBJECTIVE

A transition G to A at codon 54 of FABP2 was associated with high insulin resistance and different dietary response. The aim of our study was to investigate the influence of this polymorphism on weight loss and metabolic changes secondary to two hypocaloric diets.

SUBJECTS AND METHODS

A sample of 204 obesity patients was analyzed. Before and after 2 months of hypocaloric diet, a nutritional evaluation was performed. Patients were randomly allocated to diet I (low-fat diet) or II (low carbohydrate diet).

RESULTS

With diet Type I and in the wild group (Ala54/Ala54), BMI, weight, fat mass, waist circumference, waist to hip ratio, systolic and diastolic blood pressures, total cholesterol, triglyceride and insulin levels decreased. In the mutant group (Ala54/Thr54 and Thr54/Thr54), BMI, weight, waist circumference and fat mass decreased. In the wild group with diet Type II, the same parameters that group I decreased and glucose levels, too. In the mutant group, BMI, weight, waist circumference and fat mass decreased. Only leptin levels have a significant decrease in the wild group with both diets (diet I: 30.7%; p<0.05 and diet II: 15.85%; p<0.05).

CONCLUSION

Similar weight loss is associated with different changes, depending on the FABP genotype with both diets. Weight loss is associated with a more deep decrease in serum leptin concentration with low-fat diet.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, University of Valladolid, Valladolid, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

18701184

Citation

de Luis, D A., et al. "Influence of Ala54Thr Polymorphism of Fatty Acid-binding Protein 2 On Weight Loss and Insulin Levels Secondary to Two Hypocaloric Diets: a Randomized Clinical Trial." Diabetes Research and Clinical Practice, vol. 82, no. 1, 2008, pp. 113-8.
de Luis DA, Aller R, Izaola O, et al. Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on weight loss and insulin levels secondary to two hypocaloric diets: a randomized clinical trial. Diabetes Res Clin Pract. 2008;82(1):113-8.
de Luis, D. A., Aller, R., Izaola, O., Sagrado, M. G., & Conde, R. (2008). Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on weight loss and insulin levels secondary to two hypocaloric diets: a randomized clinical trial. Diabetes Research and Clinical Practice, 82(1), 113-8. https://doi.org/10.1016/j.diabres.2008.07.005
de Luis DA, et al. Influence of Ala54Thr Polymorphism of Fatty Acid-binding Protein 2 On Weight Loss and Insulin Levels Secondary to Two Hypocaloric Diets: a Randomized Clinical Trial. Diabetes Res Clin Pract. 2008;82(1):113-8. PubMed PMID: 18701184.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on weight loss and insulin levels secondary to two hypocaloric diets: a randomized clinical trial. AU - de Luis,D A, AU - Aller,R, AU - Izaola,O, AU - Sagrado,M Gonzalez, AU - Conde,R, Y1 - 2008/08/12/ PY - 2008/03/17/received PY - 2008/06/29/revised PY - 2008/07/01/accepted PY - 2008/8/15/pubmed PY - 2009/2/10/medline PY - 2008/8/15/entrez SP - 113 EP - 8 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 82 IS - 1 N2 - OBJECTIVE: A transition G to A at codon 54 of FABP2 was associated with high insulin resistance and different dietary response. The aim of our study was to investigate the influence of this polymorphism on weight loss and metabolic changes secondary to two hypocaloric diets. SUBJECTS AND METHODS: A sample of 204 obesity patients was analyzed. Before and after 2 months of hypocaloric diet, a nutritional evaluation was performed. Patients were randomly allocated to diet I (low-fat diet) or II (low carbohydrate diet). RESULTS: With diet Type I and in the wild group (Ala54/Ala54), BMI, weight, fat mass, waist circumference, waist to hip ratio, systolic and diastolic blood pressures, total cholesterol, triglyceride and insulin levels decreased. In the mutant group (Ala54/Thr54 and Thr54/Thr54), BMI, weight, waist circumference and fat mass decreased. In the wild group with diet Type II, the same parameters that group I decreased and glucose levels, too. In the mutant group, BMI, weight, waist circumference and fat mass decreased. Only leptin levels have a significant decrease in the wild group with both diets (diet I: 30.7%; p<0.05 and diet II: 15.85%; p<0.05). CONCLUSION: Similar weight loss is associated with different changes, depending on the FABP genotype with both diets. Weight loss is associated with a more deep decrease in serum leptin concentration with low-fat diet. SN - 1872-8227 UR - https://www.unboundmedicine.com/medline/citation/18701184/Influence_of_Ala54Thr_polymorphism_of_fatty_acid_binding_protein_2_on_weight_loss_and_insulin_levels_secondary_to_two_hypocaloric_diets:_a_randomized_clinical_trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(08)00317-3 DB - PRIME DP - Unbound Medicine ER -