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Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume.
Eur Heart J. 2008 Oct; 29(19):2343-50.EH

Abstract

Aims Chronic heart failure (CHF) is frequently associated with a decreased haemoglobin level, whereas the mechanism remains largely unknown. Methods and results One hundred consecutive CHF patients without anaemia or renal dysfunction based on non-cardiac reasons were enrolled. We explored determinants of anaemia (as iron parameters, erythropoietin, hepcidin and kidney function) including red cell volume (RCV) (by a 51 Cr assay) as well as related markers and plasma volume. The influence of each factor on haemoglobin concentrations was determined in a multiple regression model. Mean haemoglobin concentrations were 11.7 +/- 0.8 mg/dL in anaemic CHF patients and 14.4 +/- 1.2 mg/dL in non-anaemic patients. Corrected reticulocytes were lower in anaemic patients (35.1 +/- 15.7 vs. 50.3 +/- 19.2 G/L, P = 0.001), but the RCV was not reduced (1659.3 +/- 517.6 vs. 1826.4 +/- 641.3 mL, P = 0.194). We found that plasma volumes were significantly higher in anaemic CHF patients (70.0 +/- 2.4 vs. 65.0 +/- 4.0%, P < 0.001). Plasma volume was the best predictor of haemoglobin concentrations in the regression model applied (B = -0.651, P < 0.001, R(2) = 0.769). Conclusion Haemodilution appears to be the most potent factor for the development of low haemoglobin levels in patients with CHF. Our data support an additional independent, but minor influence of iron deficiency on haemoglobin concentrations in CHF patients.

Authors+Show Affiliations

Department of Internal Medicine II, Division of Cardiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18701467

Citation

Adlbrecht, Christopher, et al. "Chronic Heart Failure Leads to an Expanded Plasma Volume and Pseudoanaemia, but Does Not Lead to a Reduction in the Body's Red Cell Volume." European Heart Journal, vol. 29, no. 19, 2008, pp. 2343-50.
Adlbrecht C, Kommata S, Hülsmann M, et al. Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume. Eur Heart J. 2008;29(19):2343-50.
Adlbrecht, C., Kommata, S., Hülsmann, M., Szekeres, T., Bieglmayer, C., Strunk, G., Karanikas, G., Berger, R., Mörtl, D., Kletter, K., Maurer, G., Lang, I. M., & Pacher, R. (2008). Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume. European Heart Journal, 29(19), 2343-50. https://doi.org/10.1093/eurheartj/ehn359
Adlbrecht C, et al. Chronic Heart Failure Leads to an Expanded Plasma Volume and Pseudoanaemia, but Does Not Lead to a Reduction in the Body's Red Cell Volume. Eur Heart J. 2008;29(19):2343-50. PubMed PMID: 18701467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic heart failure leads to an expanded plasma volume and pseudoanaemia, but does not lead to a reduction in the body's red cell volume. AU - Adlbrecht,Christopher, AU - Kommata,Spyridoula, AU - Hülsmann,Martin, AU - Szekeres,Thomas, AU - Bieglmayer,Christian, AU - Strunk,Guido, AU - Karanikas,Georgios, AU - Berger,Rudolf, AU - Mörtl,Deddo, AU - Kletter,Kurt, AU - Maurer,Gerald, AU - Lang,Irene M, AU - Pacher,Richard, Y1 - 2008/08/12/ PY - 2008/8/15/pubmed PY - 2008/12/17/medline PY - 2008/8/15/entrez SP - 2343 EP - 50 JF - European heart journal JO - Eur. Heart J. VL - 29 IS - 19 N2 - Aims Chronic heart failure (CHF) is frequently associated with a decreased haemoglobin level, whereas the mechanism remains largely unknown. Methods and results One hundred consecutive CHF patients without anaemia or renal dysfunction based on non-cardiac reasons were enrolled. We explored determinants of anaemia (as iron parameters, erythropoietin, hepcidin and kidney function) including red cell volume (RCV) (by a 51 Cr assay) as well as related markers and plasma volume. The influence of each factor on haemoglobin concentrations was determined in a multiple regression model. Mean haemoglobin concentrations were 11.7 +/- 0.8 mg/dL in anaemic CHF patients and 14.4 +/- 1.2 mg/dL in non-anaemic patients. Corrected reticulocytes were lower in anaemic patients (35.1 +/- 15.7 vs. 50.3 +/- 19.2 G/L, P = 0.001), but the RCV was not reduced (1659.3 +/- 517.6 vs. 1826.4 +/- 641.3 mL, P = 0.194). We found that plasma volumes were significantly higher in anaemic CHF patients (70.0 +/- 2.4 vs. 65.0 +/- 4.0%, P < 0.001). Plasma volume was the best predictor of haemoglobin concentrations in the regression model applied (B = -0.651, P < 0.001, R(2) = 0.769). Conclusion Haemodilution appears to be the most potent factor for the development of low haemoglobin levels in patients with CHF. Our data support an additional independent, but minor influence of iron deficiency on haemoglobin concentrations in CHF patients. SN - 1522-9645 UR - https://www.unboundmedicine.com/medline/citation/18701467/Chronic_heart_failure_leads_to_an_expanded_plasma_volume_and_pseudoanaemia_but_does_not_lead_to_a_reduction_in_the_body's_red_cell_volume_ L2 - https://academic.oup.com/eurheartj/article-lookup/doi/10.1093/eurheartj/ehn359 DB - PRIME DP - Unbound Medicine ER -