Tags

Type your tag names separated by a space and hit enter

Short-term psychodynamic psychotherapy and fluoxetine in major depressive disorder: a randomized comparative study.
Psychother Psychosom. 2008; 77(6):351-7.PP

Abstract

BACKGROUND

There are few studies comparing the efficacy of short-term psychodynamic psychotherapy (STPP) and pharmacotherapy in major depressive disorder. We conducted a comparative study on the efficacy of STPP versus fluoxetine treatment in patients with major depressive disorder in a primary care setting.

METHODS

Fifty-one patients with major depressive disorder (DSM-IV) of mild or moderate severity were recruited through occupational health services providing primary health care. Patients were randomized to receive either STPP (1 session/week) or fluoxetine treatment (20-40 mg/day) for 16 weeks. The outcome measures included the Hamilton Depression Rating Scale (HDRS), the Beck Depression Inventory (BDI), and the Social and Occupational Functioning Assessment Scale (SOFAS).

RESULTS

Intent-to-treat analyses indicated that both treatments were highly effective in reducing the HDRS (p < 0.0001) and BDI (p < 0.0001) scores, as well as in improving functional ability (SOFAS; p < 0.0001), with no statistically significant differences between the treatments. Of those 40 subjects who completed the follow-up, 57% in the psychotherapy group and 68% in the fluoxetine group showed full remission (HDRS <or=7) after 4 months.

CONCLUSIONS

Both STPP and pharmacological treatment with fluoxetine are effective in reducing symptoms and in improving functional ability of primary care patients with mild or moderate depression. This study suggests no marked differences in the therapeutic effects of these two treatment forms in a primary care setting.

Authors+Show Affiliations

Department of Psychiatry, University of Helsinki, Helsinki, Finland. jokasa@utu.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18701831

Citation

Salminen, Jouko K., et al. "Short-term Psychodynamic Psychotherapy and Fluoxetine in Major Depressive Disorder: a Randomized Comparative Study." Psychotherapy and Psychosomatics, vol. 77, no. 6, 2008, pp. 351-7.
Salminen JK, Karlsson H, Hietala J, et al. Short-term psychodynamic psychotherapy and fluoxetine in major depressive disorder: a randomized comparative study. Psychother Psychosom. 2008;77(6):351-7.
Salminen, J. K., Karlsson, H., Hietala, J., Kajander, J., Aalto, S., Markkula, J., Rasi-Hakala, H., & Toikka, T. (2008). Short-term psychodynamic psychotherapy and fluoxetine in major depressive disorder: a randomized comparative study. Psychotherapy and Psychosomatics, 77(6), 351-7. https://doi.org/10.1159/000151388
Salminen JK, et al. Short-term Psychodynamic Psychotherapy and Fluoxetine in Major Depressive Disorder: a Randomized Comparative Study. Psychother Psychosom. 2008;77(6):351-7. PubMed PMID: 18701831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Short-term psychodynamic psychotherapy and fluoxetine in major depressive disorder: a randomized comparative study. AU - Salminen,Jouko K, AU - Karlsson,Hasse, AU - Hietala,Jarmo, AU - Kajander,Jaana, AU - Aalto,Sargo, AU - Markkula,Juha, AU - Rasi-Hakala,Helena, AU - Toikka,Tuula, Y1 - 2008/08/14/ PY - 2008/8/15/pubmed PY - 2009/3/18/medline PY - 2008/8/15/entrez SP - 351 EP - 7 JF - Psychotherapy and psychosomatics JO - Psychother Psychosom VL - 77 IS - 6 N2 - BACKGROUND: There are few studies comparing the efficacy of short-term psychodynamic psychotherapy (STPP) and pharmacotherapy in major depressive disorder. We conducted a comparative study on the efficacy of STPP versus fluoxetine treatment in patients with major depressive disorder in a primary care setting. METHODS: Fifty-one patients with major depressive disorder (DSM-IV) of mild or moderate severity were recruited through occupational health services providing primary health care. Patients were randomized to receive either STPP (1 session/week) or fluoxetine treatment (20-40 mg/day) for 16 weeks. The outcome measures included the Hamilton Depression Rating Scale (HDRS), the Beck Depression Inventory (BDI), and the Social and Occupational Functioning Assessment Scale (SOFAS). RESULTS: Intent-to-treat analyses indicated that both treatments were highly effective in reducing the HDRS (p < 0.0001) and BDI (p < 0.0001) scores, as well as in improving functional ability (SOFAS; p < 0.0001), with no statistically significant differences between the treatments. Of those 40 subjects who completed the follow-up, 57% in the psychotherapy group and 68% in the fluoxetine group showed full remission (HDRS <or=7) after 4 months. CONCLUSIONS: Both STPP and pharmacological treatment with fluoxetine are effective in reducing symptoms and in improving functional ability of primary care patients with mild or moderate depression. This study suggests no marked differences in the therapeutic effects of these two treatment forms in a primary care setting. SN - 1423-0348 UR - https://www.unboundmedicine.com/medline/citation/18701831/Short_term_psychodynamic_psychotherapy_and_fluoxetine_in_major_depressive_disorder:_a_randomized_comparative_study_ L2 - https://www.karger.com?DOI=10.1159/000151388 DB - PRIME DP - Unbound Medicine ER -