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Nondigestive symptoms in non-erosive reflux disease: nature, prevalence and relation to acid reflux.
Aliment Pharmacol Ther. 2008 Nov 01; 28(9):1127-33.AP

Abstract

BACKGROUND

Nondigestive symptoms are frequent in the irritable bowel syndrome (IBS).

AIM

To characterize nondigestive symptoms in non-erosive gastro-oesophageal reflux disease (NERD) patients, as features of IBS are common in patients with NERD.

METHODS

A prospective, case-control study. NERD was defined in patients with reflux symptoms, a normal oesophageal mucosa and oesophageal pH < 4 for > or = 5% of the time during 24-h pH monitoring. Nondigestive symptoms were scored on validated scales of somatic pain, urinary, sleep and neurasthenia. IBS was defined by the Rome I criteria.

RESULTS

pH-positive NERD patients (n = 326) scored significantly higher than controls (nonpatient hospital visitors; n = 174) on all scales. The scores of pain, sleep and neurasthenia were highly specific in the discrimination of NERD patients from controls. In patients, nondigestive symptoms were independently associated with age, reflux symptoms severity and IBS status, but not with oesophageal acid exposure. NERD patients who met diagnostic criteria for IBS (49%) scored significantly higher on all the nondigestive symptoms scales than those had not met [IBS(-)]. Yet, IBS(-) patients scored significantly higher than controls on all scales.

CONCLUSIONS

Nondigestive symptoms were highly prevalent in NERD patients and were specific in their discrimination from controls. Nondigestive symptoms correlated with reflux symptoms and were predicted by IBS status.

Authors+Show Affiliations

Gastroenterology Unit, Hadassah-Hebrew University Medical Centre, Jerusalem, Israel. tiberiuh@hadassah.org.ilNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18702676

Citation

Hershcovici, T, and J Zimmerman. "Nondigestive Symptoms in Non-erosive Reflux Disease: Nature, Prevalence and Relation to Acid Reflux." Alimentary Pharmacology & Therapeutics, vol. 28, no. 9, 2008, pp. 1127-33.
Hershcovici T, Zimmerman J. Nondigestive symptoms in non-erosive reflux disease: nature, prevalence and relation to acid reflux. Aliment Pharmacol Ther. 2008;28(9):1127-33.
Hershcovici, T., & Zimmerman, J. (2008). Nondigestive symptoms in non-erosive reflux disease: nature, prevalence and relation to acid reflux. Alimentary Pharmacology & Therapeutics, 28(9), 1127-33. https://doi.org/10.1111/j.1365-2036.2008.03830.x
Hershcovici T, Zimmerman J. Nondigestive Symptoms in Non-erosive Reflux Disease: Nature, Prevalence and Relation to Acid Reflux. Aliment Pharmacol Ther. 2008 Nov 1;28(9):1127-33. PubMed PMID: 18702676.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nondigestive symptoms in non-erosive reflux disease: nature, prevalence and relation to acid reflux. AU - Hershcovici,T, AU - Zimmerman,J, Y1 - 2008/08/12/ PY - 2008/8/16/pubmed PY - 2009/2/21/medline PY - 2008/8/16/entrez SP - 1127 EP - 33 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 28 IS - 9 N2 - BACKGROUND: Nondigestive symptoms are frequent in the irritable bowel syndrome (IBS). AIM: To characterize nondigestive symptoms in non-erosive gastro-oesophageal reflux disease (NERD) patients, as features of IBS are common in patients with NERD. METHODS: A prospective, case-control study. NERD was defined in patients with reflux symptoms, a normal oesophageal mucosa and oesophageal pH < 4 for > or = 5% of the time during 24-h pH monitoring. Nondigestive symptoms were scored on validated scales of somatic pain, urinary, sleep and neurasthenia. IBS was defined by the Rome I criteria. RESULTS: pH-positive NERD patients (n = 326) scored significantly higher than controls (nonpatient hospital visitors; n = 174) on all scales. The scores of pain, sleep and neurasthenia were highly specific in the discrimination of NERD patients from controls. In patients, nondigestive symptoms were independently associated with age, reflux symptoms severity and IBS status, but not with oesophageal acid exposure. NERD patients who met diagnostic criteria for IBS (49%) scored significantly higher on all the nondigestive symptoms scales than those had not met [IBS(-)]. Yet, IBS(-) patients scored significantly higher than controls on all scales. CONCLUSIONS: Nondigestive symptoms were highly prevalent in NERD patients and were specific in their discrimination from controls. Nondigestive symptoms correlated with reflux symptoms and were predicted by IBS status. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/18702676/Nondigestive_symptoms_in_non_erosive_reflux_disease:_nature_prevalence_and_relation_to_acid_reflux_ L2 - https://doi.org/10.1111/j.1365-2036.2008.03830.x DB - PRIME DP - Unbound Medicine ER -