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Alcohol consumption and blood lipids in elderly coronary patients.
Metabolism. 2008 Sep; 57(9):1286-92.M

Abstract

Alcohol may have a beneficial effect on coronary heart disease (CHD) that could be mediated by elevation of high-density lipoprotein cholesterol (HDLC). Data on alcohol consumption and blood lipids in coronary patients are scarce. We studied whether total ethanol intake and consumption of specific types of beverages are associated with blood lipids in older subjects with CHD. Blood lipids were measured in 1052 myocardial infarction patients aged 60 to 80 years (78% male). Intake of alcoholic beverages, total ethanol, and macronutrients was assessed by food frequency questionnaire. Seventy percent of the subjects used lipid-lowering medication. Total cholesterol was on average 5.14 mmol/L, and HDLC was on average 1.28 mmol/L. Among men, total ethanol intake was positively associated with HDLC (difference of 0.094 mmol/L for > or =15 g/d vs 0 g/d, P = .024), whereas the association with HDLC among women was not significant (difference of 0.060 mmol/L for > or =5 g/d vs 0 g/d, P = .560) after adjustment for dietary, lifestyle, and CHD risk factors. Liquor consumption was weakly positively associated with HDLC in men (P = .045). Beer consumption in men and wine consumption in women were also positively associated with HDLC, but were not significant in the fully adjusted model. In conclusion, moderate alcohol consumption may elevate HDLC in treated post-myocardial infarction patients. This may be due to ethanol and not to other beneficial substances in alcoholic beverages. Based on this finding, further research needs to be done to examine the effects of the residual substances from different types of alcoholic beverages on HDLC.

Authors+Show Affiliations

Division of Human Nutrition, Wageningen University, 6700 EV Wageningen, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18702956

Citation

de Jong, Hilda J I., et al. "Alcohol Consumption and Blood Lipids in Elderly Coronary Patients." Metabolism: Clinical and Experimental, vol. 57, no. 9, 2008, pp. 1286-92.
de Jong HJ, de Goede J, Oude Griep LM, et al. Alcohol consumption and blood lipids in elderly coronary patients. Metabolism. 2008;57(9):1286-92.
de Jong, H. J., de Goede, J., Oude Griep, L. M., & Geleijnse, J. M. (2008). Alcohol consumption and blood lipids in elderly coronary patients. Metabolism: Clinical and Experimental, 57(9), 1286-92. https://doi.org/10.1016/j.metabol.2008.04.025
de Jong HJ, et al. Alcohol Consumption and Blood Lipids in Elderly Coronary Patients. Metabolism. 2008;57(9):1286-92. PubMed PMID: 18702956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol consumption and blood lipids in elderly coronary patients. AU - de Jong,Hilda J I, AU - de Goede,Janette, AU - Oude Griep,Linda M, AU - Geleijnse,Johanna M, PY - 2008/01/26/received PY - 2008/04/07/accepted PY - 2008/8/16/pubmed PY - 2008/9/17/medline PY - 2008/8/16/entrez SP - 1286 EP - 92 JF - Metabolism: clinical and experimental JO - Metabolism VL - 57 IS - 9 N2 - Alcohol may have a beneficial effect on coronary heart disease (CHD) that could be mediated by elevation of high-density lipoprotein cholesterol (HDLC). Data on alcohol consumption and blood lipids in coronary patients are scarce. We studied whether total ethanol intake and consumption of specific types of beverages are associated with blood lipids in older subjects with CHD. Blood lipids were measured in 1052 myocardial infarction patients aged 60 to 80 years (78% male). Intake of alcoholic beverages, total ethanol, and macronutrients was assessed by food frequency questionnaire. Seventy percent of the subjects used lipid-lowering medication. Total cholesterol was on average 5.14 mmol/L, and HDLC was on average 1.28 mmol/L. Among men, total ethanol intake was positively associated with HDLC (difference of 0.094 mmol/L for > or =15 g/d vs 0 g/d, P = .024), whereas the association with HDLC among women was not significant (difference of 0.060 mmol/L for > or =5 g/d vs 0 g/d, P = .560) after adjustment for dietary, lifestyle, and CHD risk factors. Liquor consumption was weakly positively associated with HDLC in men (P = .045). Beer consumption in men and wine consumption in women were also positively associated with HDLC, but were not significant in the fully adjusted model. In conclusion, moderate alcohol consumption may elevate HDLC in treated post-myocardial infarction patients. This may be due to ethanol and not to other beneficial substances in alcoholic beverages. Based on this finding, further research needs to be done to examine the effects of the residual substances from different types of alcoholic beverages on HDLC. SN - 1532-8600 UR - https://www.unboundmedicine.com/medline/citation/18702956/Alcohol_consumption_and_blood_lipids_in_elderly_coronary_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(08)00156-X DB - PRIME DP - Unbound Medicine ER -