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Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells.
Int Immunol. 2008 Oct; 20(10):1321-9.II

Abstract

Allergic diseases such as atopic dermatitis and asthma develop as a consequence of dysregulated T(h)2 responses. Recently, it has been demonstrated that interaction between dendritic cells (DCs) and thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is essential for evoking T(h)2 responses in allergy. In this study, we investigated whether Mycobacterium bovis Bacillus Calmette-Guérin (BCG), a strong T(h)1 response-inducing adjuvant, can alter the function of DCs activated by TSLP (TSLP-DCs). We demonstrated that BCG redirects TSLP-DCs away from inducing inflammatory T(h)2 cells that produce IL-4, IL-5, IL-13 and tumor necrosis factor (TNF)-alpha and toward regulatory T(h)1 cells that produce IFN-gamma and IL-10. We also demonstrated that this functional alteration of TSLP-DCs by BCG depended on both production of IL-12 from DCs and down-regulation of OX40 ligand, a member of the TNF family, on DCs. These findings suggest that BCG might be a useful adjuvant for the treatment of allergic diseases that are triggered by TSLP.

Authors+Show Affiliations

First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18703465

Citation

Yokoi, Takashi, et al. "Mycobacterium Bovis Bacillus Calmette-Guérin Suppresses Inflammatory Th2 Responses By Inducing Functional Alteration of TSLP-activated Dendritic Cells." International Immunology, vol. 20, no. 10, 2008, pp. 1321-9.
Yokoi T, Amakawa R, Tanijiri T, et al. Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol. 2008;20(10):1321-9.
Yokoi, T., Amakawa, R., Tanijiri, T., Sugimoto, H., Torii, Y., Amuro, H., Son, Y., Tajima, K., Liu, Y. J., Ito, T., & Fukuhara, S. (2008). Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. International Immunology, 20(10), 1321-9. https://doi.org/10.1093/intimm/dxn094
Yokoi T, et al. Mycobacterium Bovis Bacillus Calmette-Guérin Suppresses Inflammatory Th2 Responses By Inducing Functional Alteration of TSLP-activated Dendritic Cells. Int Immunol. 2008;20(10):1321-9. PubMed PMID: 18703465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. AU - Yokoi,Takashi, AU - Amakawa,Ryuichi, AU - Tanijiri,Tsutomu, AU - Sugimoto,Hiroyuki, AU - Torii,Yoshitaro, AU - Amuro,Hideki, AU - Son,Yonsu, AU - Tajima,Kenichirou, AU - Liu,Yong-Jun, AU - Ito,Tomoki, AU - Fukuhara,Shirou, Y1 - 2008/08/13/ PY - 2008/8/16/pubmed PY - 2008/11/11/medline PY - 2008/8/16/entrez SP - 1321 EP - 9 JF - International immunology JO - Int Immunol VL - 20 IS - 10 N2 - Allergic diseases such as atopic dermatitis and asthma develop as a consequence of dysregulated T(h)2 responses. Recently, it has been demonstrated that interaction between dendritic cells (DCs) and thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is essential for evoking T(h)2 responses in allergy. In this study, we investigated whether Mycobacterium bovis Bacillus Calmette-Guérin (BCG), a strong T(h)1 response-inducing adjuvant, can alter the function of DCs activated by TSLP (TSLP-DCs). We demonstrated that BCG redirects TSLP-DCs away from inducing inflammatory T(h)2 cells that produce IL-4, IL-5, IL-13 and tumor necrosis factor (TNF)-alpha and toward regulatory T(h)1 cells that produce IFN-gamma and IL-10. We also demonstrated that this functional alteration of TSLP-DCs by BCG depended on both production of IL-12 from DCs and down-regulation of OX40 ligand, a member of the TNF family, on DCs. These findings suggest that BCG might be a useful adjuvant for the treatment of allergic diseases that are triggered by TSLP. SN - 1460-2377 UR - https://www.unboundmedicine.com/medline/citation/18703465/Mycobacterium_bovis_Bacillus_Calmette_Guérin_suppresses_inflammatory_Th2_responses_by_inducing_functional_alteration_of_TSLP_activated_dendritic_cells_ L2 - https://academic.oup.com/intimm/article-lookup/doi/10.1093/intimm/dxn094 DB - PRIME DP - Unbound Medicine ER -