Citation
Yokoi, Takashi, et al. "Mycobacterium Bovis Bacillus Calmette-Guérin Suppresses Inflammatory Th2 Responses By Inducing Functional Alteration of TSLP-activated Dendritic Cells." International Immunology, vol. 20, no. 10, 2008, pp. 1321-9.
Yokoi T, Amakawa R, Tanijiri T, et al. Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol. 2008;20(10):1321-9.
Yokoi, T., Amakawa, R., Tanijiri, T., Sugimoto, H., Torii, Y., Amuro, H., Son, Y., Tajima, K., Liu, Y. J., Ito, T., & Fukuhara, S. (2008). Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. International Immunology, 20(10), 1321-9. https://doi.org/10.1093/intimm/dxn094
Yokoi T, et al. Mycobacterium Bovis Bacillus Calmette-Guérin Suppresses Inflammatory Th2 Responses By Inducing Functional Alteration of TSLP-activated Dendritic Cells. Int Immunol. 2008;20(10):1321-9. PubMed PMID: 18703465.
TY - JOUR
T1 - Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells.
AU - Yokoi,Takashi,
AU - Amakawa,Ryuichi,
AU - Tanijiri,Tsutomu,
AU - Sugimoto,Hiroyuki,
AU - Torii,Yoshitaro,
AU - Amuro,Hideki,
AU - Son,Yonsu,
AU - Tajima,Kenichirou,
AU - Liu,Yong-Jun,
AU - Ito,Tomoki,
AU - Fukuhara,Shirou,
Y1 - 2008/08/13/
PY - 2008/8/16/pubmed
PY - 2008/11/11/medline
PY - 2008/8/16/entrez
SP - 1321
EP - 9
JF - International immunology
JO - Int Immunol
VL - 20
IS - 10
N2 - Allergic diseases such as atopic dermatitis and asthma develop as a consequence of dysregulated T(h)2 responses. Recently, it has been demonstrated that interaction between dendritic cells (DCs) and thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is essential for evoking T(h)2 responses in allergy. In this study, we investigated whether Mycobacterium bovis Bacillus Calmette-Guérin (BCG), a strong T(h)1 response-inducing adjuvant, can alter the function of DCs activated by TSLP (TSLP-DCs). We demonstrated that BCG redirects TSLP-DCs away from inducing inflammatory T(h)2 cells that produce IL-4, IL-5, IL-13 and tumor necrosis factor (TNF)-alpha and toward regulatory T(h)1 cells that produce IFN-gamma and IL-10. We also demonstrated that this functional alteration of TSLP-DCs by BCG depended on both production of IL-12 from DCs and down-regulation of OX40 ligand, a member of the TNF family, on DCs. These findings suggest that BCG might be a useful adjuvant for the treatment of allergic diseases that are triggered by TSLP.
SN - 1460-2377
UR - https://www.unboundmedicine.com/medline/citation/18703465/Mycobacterium_bovis_Bacillus_Calmette_Guérin_suppresses_inflammatory_Th2_responses_by_inducing_functional_alteration_of_TSLP_activated_dendritic_cells_
L2 - https://academic.oup.com/intimm/article-lookup/doi/10.1093/intimm/dxn094
DB - PRIME
DP - Unbound Medicine
ER -