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Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells.
Int Immunol. 2008 Oct; 20(10):1321-9.II

Abstract

Allergic diseases such as atopic dermatitis and asthma develop as a consequence of dysregulated T(h)2 responses. Recently, it has been demonstrated that interaction between dendritic cells (DCs) and thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is essential for evoking T(h)2 responses in allergy. In this study, we investigated whether Mycobacterium bovis Bacillus Calmette-Guérin (BCG), a strong T(h)1 response-inducing adjuvant, can alter the function of DCs activated by TSLP (TSLP-DCs). We demonstrated that BCG redirects TSLP-DCs away from inducing inflammatory T(h)2 cells that produce IL-4, IL-5, IL-13 and tumor necrosis factor (TNF)-alpha and toward regulatory T(h)1 cells that produce IFN-gamma and IL-10. We also demonstrated that this functional alteration of TSLP-DCs by BCG depended on both production of IL-12 from DCs and down-regulation of OX40 ligand, a member of the TNF family, on DCs. These findings suggest that BCG might be a useful adjuvant for the treatment of allergic diseases that are triggered by TSLP.

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Authors+Show Affiliations

Yokoi T
First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Amakawa R
No affiliation info available
Tanijiri T
No affiliation info available
Sugimoto H
No affiliation info available
Torii Y
No affiliation info available
Amuro H
No affiliation info available
Son Y
No affiliation info available
Tajima K
No affiliation info available
Liu YJ
No affiliation info available
Ito T
No affiliation info available
Fukuhara S
No affiliation info available

MeSH

BCG VaccineCell DifferentiationCytokinesDendritic CellsHumansHypersensitivityImmunosuppressionImmunotherapyLymphocyte ActivationMycobacterium InfectionsMycobacterium bovisOX40 LigandTh1 CellsTh2 Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18703465

Citation

Yokoi, Takashi, et al. "Mycobacterium Bovis Bacillus Calmette-Guérin Suppresses Inflammatory Th2 Responses By Inducing Functional Alteration of TSLP-activated Dendritic Cells." International Immunology, vol. 20, no. 10, 2008, pp. 1321-9.
Yokoi T, Amakawa R, Tanijiri T, et al. Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. Int Immunol. 2008;20(10):1321-9.
Yokoi, T., Amakawa, R., Tanijiri, T., Sugimoto, H., Torii, Y., Amuro, H., Son, Y., Tajima, K., Liu, Y. J., Ito, T., & Fukuhara, S. (2008). Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. International Immunology, 20(10), 1321-9. https://doi.org/10.1093/intimm/dxn094
Yokoi T, et al. Mycobacterium Bovis Bacillus Calmette-Guérin Suppresses Inflammatory Th2 Responses By Inducing Functional Alteration of TSLP-activated Dendritic Cells. Int Immunol. 2008;20(10):1321-9. PubMed PMID: 18703465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mycobacterium bovis Bacillus Calmette-Guérin suppresses inflammatory Th2 responses by inducing functional alteration of TSLP-activated dendritic cells. AU - Yokoi,Takashi, AU - Amakawa,Ryuichi, AU - Tanijiri,Tsutomu, AU - Sugimoto,Hiroyuki, AU - Torii,Yoshitaro, AU - Amuro,Hideki, AU - Son,Yonsu, AU - Tajima,Kenichirou, AU - Liu,Yong-Jun, AU - Ito,Tomoki, AU - Fukuhara,Shirou, Y1 - 2008/08/13/ PY - 2008/8/16/pubmed PY - 2008/11/11/medline PY - 2008/8/16/entrez SP - 1321 EP - 9 JF - International immunology JO - Int Immunol VL - 20 IS - 10 N2 - Allergic diseases such as atopic dermatitis and asthma develop as a consequence of dysregulated T(h)2 responses. Recently, it has been demonstrated that interaction between dendritic cells (DCs) and thymic stromal lymphopoietin (TSLP), an IL-7-like cytokine, is essential for evoking T(h)2 responses in allergy. In this study, we investigated whether Mycobacterium bovis Bacillus Calmette-Guérin (BCG), a strong T(h)1 response-inducing adjuvant, can alter the function of DCs activated by TSLP (TSLP-DCs). We demonstrated that BCG redirects TSLP-DCs away from inducing inflammatory T(h)2 cells that produce IL-4, IL-5, IL-13 and tumor necrosis factor (TNF)-alpha and toward regulatory T(h)1 cells that produce IFN-gamma and IL-10. We also demonstrated that this functional alteration of TSLP-DCs by BCG depended on both production of IL-12 from DCs and down-regulation of OX40 ligand, a member of the TNF family, on DCs. These findings suggest that BCG might be a useful adjuvant for the treatment of allergic diseases that are triggered by TSLP. SN - 1460-2377 UR - https://www.unboundmedicine.com/medline/citation/18703465/Mycobacterium_bovis_Bacillus_Calmette_Guérin_suppresses_inflammatory_Th2_responses_by_inducing_functional_alteration_of_TSLP_activated_dendritic_cells_ L2 - https://academic.oup.com/intimm/article-lookup/doi/10.1093/intimm/dxn094 DB - PRIME DP - Unbound Medicine ER -