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Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease.
Age Ageing. 2008 Nov; 37(6):653-9.AA

Abstract

OBJECTIVE

to determine whether functional changes in the vasculature differ between Alzheimer's disease (AD) and vascular dementia (VAD).

DESIGN

we determined vascular stiffness in patients with a clinical and radiological diagnosis of either AD or VAD and compared them to normal age- and sex-matched controls.

METHODS

In all, 16 patients with late onset AD, 13 subjects with VAD and 16 age- and sex-matched controls were recruited to this study. Central arterial compliance (CAC), augmentation index (AI) and pulse wave velocity (PWV) (measures of arterial stiffness) were measured.

RESULTS

the mean age was 77.7 +/- 8.3 years (mean +/- SD) in the AD group, 79.7 +/- 8.9 years in the VAD group and 76.4 +/- 6.9 in the controls (P = 0.44). CAC was significantly lower in subjects with VAD compared to both the AD and the control groups (0.57 +/- 0.46 ml/mm Hg versus 1.12 +/- 0.57 and 1.1 +/- 0.47 ml/mm Hg respectively, P = 0.01). AI was significantly higher in the subjects with VAD compared to both the AD and the control groups (13.3 +/- 9.0 versus 3.5 +/- 11.4 and 4.2 +/- 9.7% respectively, P = 0.03). PWV in the muscular and elastic arteries were not statistically different between the three groups but tended to be highest in the VAD group for carotid-radial measurements.

CONCLUSIONS

the reduced CAC and increased AI in VAD subjects indicate that the disease process is associated with less vascular compliance of the large elastic arteries in these patients, but not in patients with AD.

Authors+Show Affiliations

Faculty of Medicine, Imperial College, London, UK.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18703522

Citation

Dhoat, Sasha, et al. "Vascular Compliance Is Reduced in Vascular Dementia and Not in Alzheimer's Disease." Age and Ageing, vol. 37, no. 6, 2008, pp. 653-9.
Dhoat S, Ali K, Bulpitt CJ, et al. Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease. Age Ageing. 2008;37(6):653-9.
Dhoat, S., Ali, K., Bulpitt, C. J., & Rajkumar, C. (2008). Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease. Age and Ageing, 37(6), 653-9. https://doi.org/10.1093/ageing/afn158
Dhoat S, et al. Vascular Compliance Is Reduced in Vascular Dementia and Not in Alzheimer's Disease. Age Ageing. 2008;37(6):653-9. PubMed PMID: 18703522.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vascular compliance is reduced in vascular dementia and not in Alzheimer's disease. AU - Dhoat,Sasha, AU - Ali,Khalid, AU - Bulpitt,Christopher J, AU - Rajkumar,Chakravarthi, Y1 - 2008/08/13/ PY - 2008/8/16/pubmed PY - 2009/2/10/medline PY - 2008/8/16/entrez SP - 653 EP - 9 JF - Age and ageing JO - Age Ageing VL - 37 IS - 6 N2 - OBJECTIVE: to determine whether functional changes in the vasculature differ between Alzheimer's disease (AD) and vascular dementia (VAD). DESIGN: we determined vascular stiffness in patients with a clinical and radiological diagnosis of either AD or VAD and compared them to normal age- and sex-matched controls. METHODS: In all, 16 patients with late onset AD, 13 subjects with VAD and 16 age- and sex-matched controls were recruited to this study. Central arterial compliance (CAC), augmentation index (AI) and pulse wave velocity (PWV) (measures of arterial stiffness) were measured. RESULTS: the mean age was 77.7 +/- 8.3 years (mean +/- SD) in the AD group, 79.7 +/- 8.9 years in the VAD group and 76.4 +/- 6.9 in the controls (P = 0.44). CAC was significantly lower in subjects with VAD compared to both the AD and the control groups (0.57 +/- 0.46 ml/mm Hg versus 1.12 +/- 0.57 and 1.1 +/- 0.47 ml/mm Hg respectively, P = 0.01). AI was significantly higher in the subjects with VAD compared to both the AD and the control groups (13.3 +/- 9.0 versus 3.5 +/- 11.4 and 4.2 +/- 9.7% respectively, P = 0.03). PWV in the muscular and elastic arteries were not statistically different between the three groups but tended to be highest in the VAD group for carotid-radial measurements. CONCLUSIONS: the reduced CAC and increased AI in VAD subjects indicate that the disease process is associated with less vascular compliance of the large elastic arteries in these patients, but not in patients with AD. SN - 1468-2834 UR - https://www.unboundmedicine.com/medline/citation/18703522/Vascular_compliance_is_reduced_in_vascular_dementia_and_not_in_Alzheimer's_disease_ L2 - https://academic.oup.com/ageing/article-lookup/doi/10.1093/ageing/afn158 DB - PRIME DP - Unbound Medicine ER -