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Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach.
J Clin Pathol. 2008 Dec; 61(12):1303-13.JC

Abstract

Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing neoplasms with a frequent papillary architecture that arise within the pancreatic ducts and are increasingly being recognised. Because they exhibit a spectrum of dysplasia ranging from low grade to high grade and may also have associated invasive carcinoma, and because they are clinically detectable, they are now intensively studied. There is marked overlap between IPMNs and pancreatic intraepithelial neoplasia (PanIN), such that the distinction between these two lesions is nearly impossible in certain cases. In addition, IPMNs sometimes can be confused with other primary cystic lesions of the pancreas. As a result, the correct diagnosis of IPMN can be challenging. This review addresses the clinical and pathological features of IPMNs, emphasising their diagnostic criteria, differential diagnosis and biological behaviour. Problematic issues in the pathological evaluation of IPMNs are discussed.

Authors+Show Affiliations

Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. klimstrd@mskcc.orgNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18703569

Citation

Katabi, N, and D S. Klimstra. "Intraductal Papillary Mucinous Neoplasms of the Pancreas: Clinical and Pathological Features and Diagnostic Approach." Journal of Clinical Pathology, vol. 61, no. 12, 2008, pp. 1303-13.
Katabi N, Klimstra DS. Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach. J Clin Pathol. 2008;61(12):1303-13.
Katabi, N., & Klimstra, D. S. (2008). Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach. Journal of Clinical Pathology, 61(12), 1303-13. https://doi.org/10.1136/jcp.2007.049361
Katabi N, Klimstra DS. Intraductal Papillary Mucinous Neoplasms of the Pancreas: Clinical and Pathological Features and Diagnostic Approach. J Clin Pathol. 2008;61(12):1303-13. PubMed PMID: 18703569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraductal papillary mucinous neoplasms of the pancreas: clinical and pathological features and diagnostic approach. AU - Katabi,N, AU - Klimstra,D S, Y1 - 2008/08/14/ PY - 2008/8/16/entrez PY - 2008/8/16/pubmed PY - 2009/3/12/medline SP - 1303 EP - 13 JF - Journal of clinical pathology JO - J Clin Pathol VL - 61 IS - 12 N2 - Pancreatic intraductal papillary mucinous neoplasms (IPMNs) are mucin-producing neoplasms with a frequent papillary architecture that arise within the pancreatic ducts and are increasingly being recognised. Because they exhibit a spectrum of dysplasia ranging from low grade to high grade and may also have associated invasive carcinoma, and because they are clinically detectable, they are now intensively studied. There is marked overlap between IPMNs and pancreatic intraepithelial neoplasia (PanIN), such that the distinction between these two lesions is nearly impossible in certain cases. In addition, IPMNs sometimes can be confused with other primary cystic lesions of the pancreas. As a result, the correct diagnosis of IPMN can be challenging. This review addresses the clinical and pathological features of IPMNs, emphasising their diagnostic criteria, differential diagnosis and biological behaviour. Problematic issues in the pathological evaluation of IPMNs are discussed. SN - 1472-4146 UR - https://www.unboundmedicine.com/medline/citation/18703569/Intraductal_papillary_mucinous_neoplasms_of_the_pancreas:_clinical_and_pathological_features_and_diagnostic_approach_ L2 - https://jcp.bmj.com/lookup/pmidlookup?view=long&pmid=18703569 DB - PRIME DP - Unbound Medicine ER -