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Effect of aging on nocturnal blood flow in the optic nerve head and macula in healthy human eyes.
J Glaucoma 2008; 17(5):366-71JG

Abstract

PURPOSE

To study the effect of aging on 24-hour blood flow in the optic nerve head and macula of healthy human eyes.

METHODS

Fifteen older volunteers with healthy eyes (age 50 to 80 y) and 15 healthy younger volunteers (age 20 to 25 y) were housed for 1 day in a sleep laboratory. Every 2 hours, blood pressure and intraocular pressure (IOP) were measured after 5 minutes in the sitting position. Ocular perfusion pressure was calculated. Indices of blood volume, flow, and velocity in the optic nerve head and macula were measured using a scanning laser Doppler flowmeter at the same time points.

RESULTS

Within the group of older subjects, nocturnal IOP was significantly lower than diurnal IOP. There was no significant difference in the ocular perfusion pressure between the 2 time periods. However, there were statistically significant decreases (6.8% to 16.8%) in the ocular blood flow parameters from the diurnal period to the nocturnal period. Within the group of younger subjects, nocturnal IOP was higher and nocturnal ocular perfusion pressure was lower than the corresponding diurnal values. There was no significant difference in any ocular blood flow parameter between the diurnal and nocturnal periods. Comparing the older and younger subject groups, nocturnal ocular perfusion pressure was higher in the older group.

CONCLUSIONS

Significant diurnal-to-nocturnal decreases in blood flow occurred in the optic nerve head and macula in the older subjects, but not in the younger subjects. These diurnal-to-nocturnal change patterns in ocular blood flow were independent of the change patterns in ocular perfusion pressure.

Authors+Show Affiliations

Hamilton Glaucoma Center and Department of Ophthalmology, University of California, San Diego, La Jolla, CA 92093-0946, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18703946

Citation

Kida, Teruyo, et al. "Effect of Aging On Nocturnal Blood Flow in the Optic Nerve Head and Macula in Healthy Human Eyes." Journal of Glaucoma, vol. 17, no. 5, 2008, pp. 366-71.
Kida T, Liu JH, Weinreb RN. Effect of aging on nocturnal blood flow in the optic nerve head and macula in healthy human eyes. J Glaucoma. 2008;17(5):366-71.
Kida, T., Liu, J. H., & Weinreb, R. N. (2008). Effect of aging on nocturnal blood flow in the optic nerve head and macula in healthy human eyes. Journal of Glaucoma, 17(5), pp. 366-71. doi:10.1097/IJG.0b013e31815d7838.
Kida T, Liu JH, Weinreb RN. Effect of Aging On Nocturnal Blood Flow in the Optic Nerve Head and Macula in Healthy Human Eyes. J Glaucoma. 2008;17(5):366-71. PubMed PMID: 18703946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of aging on nocturnal blood flow in the optic nerve head and macula in healthy human eyes. AU - Kida,Teruyo, AU - Liu,John H K, AU - Weinreb,Robert N, PY - 2008/8/16/pubmed PY - 2008/12/17/medline PY - 2008/8/16/entrez SP - 366 EP - 71 JF - Journal of glaucoma JO - J. Glaucoma VL - 17 IS - 5 N2 - PURPOSE: To study the effect of aging on 24-hour blood flow in the optic nerve head and macula of healthy human eyes. METHODS: Fifteen older volunteers with healthy eyes (age 50 to 80 y) and 15 healthy younger volunteers (age 20 to 25 y) were housed for 1 day in a sleep laboratory. Every 2 hours, blood pressure and intraocular pressure (IOP) were measured after 5 minutes in the sitting position. Ocular perfusion pressure was calculated. Indices of blood volume, flow, and velocity in the optic nerve head and macula were measured using a scanning laser Doppler flowmeter at the same time points. RESULTS: Within the group of older subjects, nocturnal IOP was significantly lower than diurnal IOP. There was no significant difference in the ocular perfusion pressure between the 2 time periods. However, there were statistically significant decreases (6.8% to 16.8%) in the ocular blood flow parameters from the diurnal period to the nocturnal period. Within the group of younger subjects, nocturnal IOP was higher and nocturnal ocular perfusion pressure was lower than the corresponding diurnal values. There was no significant difference in any ocular blood flow parameter between the diurnal and nocturnal periods. Comparing the older and younger subject groups, nocturnal ocular perfusion pressure was higher in the older group. CONCLUSIONS: Significant diurnal-to-nocturnal decreases in blood flow occurred in the optic nerve head and macula in the older subjects, but not in the younger subjects. These diurnal-to-nocturnal change patterns in ocular blood flow were independent of the change patterns in ocular perfusion pressure. SN - 1536-481X UR - https://www.unboundmedicine.com/medline/citation/18703946/Effect_of_aging_on_nocturnal_blood_flow_in_the_optic_nerve_head_and_macula_in_healthy_human_eyes_ L2 - http://Insights.ovid.com/pubmed?pmid=18703946 DB - PRIME DP - Unbound Medicine ER -