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Coffee and caffeine intake and the risk of ovarian cancer: the Iowa Women's Health Study.
Cancer Causes Control. 2008 Dec; 19(10):1365-72.CC

Abstract

Laboratory data suggest that caffeine or some components of coffee may cause DNA mutations and inhibit tumor suppressor mechanisms, leading to neoplastic growth. However, coffee consumption has not been clearly implicated in the etiology of human postmenopausal ovarian cancer. This study evaluated the relationship of coffee and caffeine intake with risk of epithelial ovarian cancer in a prospective cohort study of 29,060 postmenopausal women. The participants completed a mailed questionnaire that assessed diet and health history and were followed for ovarian cancer incidence from 1986 to 2004. Age-adjusted and multivariate-adjusted hazard ratios were calculated for four exposure variables: caffeinated coffee, decaffeinated coffee, total coffee, and total caffeine to assess whether or not coffee or caffeine influences the risk of ovarian cancer. An increased risk was observed in the multivariate model for women who reported drinking five or more cups/day of caffeinated coffee compared to women who reported drinking none (HR = 1.81, 95% CI: 1.10-2.95). Decaffeinated coffee, total coffee, and caffeine were not statistically significantly associated with ovarian cancer incidence. Our results suggest that a component of coffee other than caffeine, or in combination with caffeine, may be associated with increased risk of ovarian cancer in postmenopausal women who drink five or more cups of coffee a day.

Authors+Show Affiliations

Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18704717

Citation

Lueth, Natalie A., et al. "Coffee and Caffeine Intake and the Risk of Ovarian Cancer: the Iowa Women's Health Study." Cancer Causes & Control : CCC, vol. 19, no. 10, 2008, pp. 1365-72.
Lueth NA, Anderson KE, Harnack LJ, et al. Coffee and caffeine intake and the risk of ovarian cancer: the Iowa Women's Health Study. Cancer Causes Control. 2008;19(10):1365-72.
Lueth, N. A., Anderson, K. E., Harnack, L. J., Fulkerson, J. A., & Robien, K. (2008). Coffee and caffeine intake and the risk of ovarian cancer: the Iowa Women's Health Study. Cancer Causes & Control : CCC, 19(10), 1365-72. https://doi.org/10.1007/s10552-008-9208-8
Lueth NA, et al. Coffee and Caffeine Intake and the Risk of Ovarian Cancer: the Iowa Women's Health Study. Cancer Causes Control. 2008;19(10):1365-72. PubMed PMID: 18704717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coffee and caffeine intake and the risk of ovarian cancer: the Iowa Women's Health Study. AU - Lueth,Natalie A, AU - Anderson,Kristin E, AU - Harnack,Lisa J, AU - Fulkerson,Jayne A, AU - Robien,Kim, Y1 - 2008/08/14/ PY - 2008/04/02/received PY - 2008/07/01/accepted PY - 2008/8/16/pubmed PY - 2009/2/13/medline PY - 2008/8/16/entrez SP - 1365 EP - 72 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 19 IS - 10 N2 - Laboratory data suggest that caffeine or some components of coffee may cause DNA mutations and inhibit tumor suppressor mechanisms, leading to neoplastic growth. However, coffee consumption has not been clearly implicated in the etiology of human postmenopausal ovarian cancer. This study evaluated the relationship of coffee and caffeine intake with risk of epithelial ovarian cancer in a prospective cohort study of 29,060 postmenopausal women. The participants completed a mailed questionnaire that assessed diet and health history and were followed for ovarian cancer incidence from 1986 to 2004. Age-adjusted and multivariate-adjusted hazard ratios were calculated for four exposure variables: caffeinated coffee, decaffeinated coffee, total coffee, and total caffeine to assess whether or not coffee or caffeine influences the risk of ovarian cancer. An increased risk was observed in the multivariate model for women who reported drinking five or more cups/day of caffeinated coffee compared to women who reported drinking none (HR = 1.81, 95% CI: 1.10-2.95). Decaffeinated coffee, total coffee, and caffeine were not statistically significantly associated with ovarian cancer incidence. Our results suggest that a component of coffee other than caffeine, or in combination with caffeine, may be associated with increased risk of ovarian cancer in postmenopausal women who drink five or more cups of coffee a day. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/18704717/Coffee_and_caffeine_intake_and_the_risk_of_ovarian_cancer:_the_Iowa_Women's_Health_Study_ L2 - https://doi.org/10.1007/s10552-008-9208-8 DB - PRIME DP - Unbound Medicine ER -