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Nerve conduction studies and prediction of mortality in hemodialysis patients.
Ren Fail. 2008; 30(7):695-9.RF

Abstract

BACKGROUND

The electrophysiological aspects of uremic neuropathy have been studied extensively, but never for prediction of mortality. In order to assess the parameters of nerve conduction study (NCS) as predictors of mortality in hemodialysis patients, a post hoc analysis of a prospective observation study was made.

METHODS

We examined conventional electrophysiological parameters (motor nerve conduction velocity [MCV], terminal latency [TL], and F wave latency of the peroneal nerve, as well as sensory nerve conduction velocity [SCV] of the sural nerve) in 75 nondiabetic patients. Hemodialysis modality (bicarbonate dialysis and biocompatible membranes), Kt/V, comorbidity (ischemic heart disease and congestive heart failure), and clinical and laboratory parameters were also evaluated. Survival was analyzed using the Cox proportional hazard model.

RESULTS

SCV was significantly higher (t-test, p < 0.01) in the group of patients treated with polysulfone compared to those using cuprophane membranes. On the other hand, MCV significantly correlated with Kt/V (Pearson, r = 0.388; p < 0.01). Multivariate Cox regression revealed only MCV as a significant predictor of mortality in this group of hemodialysis patients (HR = 0.92; CI (0.86-0.99); p < 0.05).

CONCLUSION

Only MCV was a significant mortality risk predictor among NCS parameters. This parameter correlates significantly with dialysis dose. SCV was related to the use of biocompatible membranes, indicating the complexity of polyneuropathy in dialysis patients.

Authors+Show Affiliations

Institute of Urology and Nephrology, Clinic of Nephrology, Clinical Center of Serbia, Belgrade, Serbia. milanst@eunet.rsNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18704818

Citation

Stosovic, Milan, et al. "Nerve Conduction Studies and Prediction of Mortality in Hemodialysis Patients." Renal Failure, vol. 30, no. 7, 2008, pp. 695-9.
Stosovic M, Nikolic A, Stanojevic M, et al. Nerve conduction studies and prediction of mortality in hemodialysis patients. Ren Fail. 2008;30(7):695-9.
Stosovic, M., Nikolic, A., Stanojevic, M., Simic-Ogrizovic, S., Radovic, M., Jovanovic, D., Popovic, Z., Trikic, R., & Djukanovic, L. (2008). Nerve conduction studies and prediction of mortality in hemodialysis patients. Renal Failure, 30(7), 695-9. https://doi.org/10.1080/08860220802212890
Stosovic M, et al. Nerve Conduction Studies and Prediction of Mortality in Hemodialysis Patients. Ren Fail. 2008;30(7):695-9. PubMed PMID: 18704818.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nerve conduction studies and prediction of mortality in hemodialysis patients. AU - Stosovic,Milan, AU - Nikolic,Ana, AU - Stanojevic,Mirjana, AU - Simic-Ogrizovic,Sanja, AU - Radovic,Milan, AU - Jovanovic,Dijana, AU - Popovic,Zoran, AU - Trikic,Rajko, AU - Djukanovic,Ljubica, PY - 2008/8/16/pubmed PY - 2008/11/14/medline PY - 2008/8/16/entrez SP - 695 EP - 9 JF - Renal failure JO - Ren Fail VL - 30 IS - 7 N2 - BACKGROUND: The electrophysiological aspects of uremic neuropathy have been studied extensively, but never for prediction of mortality. In order to assess the parameters of nerve conduction study (NCS) as predictors of mortality in hemodialysis patients, a post hoc analysis of a prospective observation study was made. METHODS: We examined conventional electrophysiological parameters (motor nerve conduction velocity [MCV], terminal latency [TL], and F wave latency of the peroneal nerve, as well as sensory nerve conduction velocity [SCV] of the sural nerve) in 75 nondiabetic patients. Hemodialysis modality (bicarbonate dialysis and biocompatible membranes), Kt/V, comorbidity (ischemic heart disease and congestive heart failure), and clinical and laboratory parameters were also evaluated. Survival was analyzed using the Cox proportional hazard model. RESULTS: SCV was significantly higher (t-test, p < 0.01) in the group of patients treated with polysulfone compared to those using cuprophane membranes. On the other hand, MCV significantly correlated with Kt/V (Pearson, r = 0.388; p < 0.01). Multivariate Cox regression revealed only MCV as a significant predictor of mortality in this group of hemodialysis patients (HR = 0.92; CI (0.86-0.99); p < 0.05). CONCLUSION: Only MCV was a significant mortality risk predictor among NCS parameters. This parameter correlates significantly with dialysis dose. SCV was related to the use of biocompatible membranes, indicating the complexity of polyneuropathy in dialysis patients. SN - 1525-6049 UR - https://www.unboundmedicine.com/medline/citation/18704818/Nerve_conduction_studies_and_prediction_of_mortality_in_hemodialysis_patients_ L2 - http://www.tandfonline.com/doi/full/10.1080/08860220802212890 DB - PRIME DP - Unbound Medicine ER -