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Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy.
Head Neck. 2008 Dec; 30(12):1543-51.HN

Abstract

BACKGROUND

Treatment of head and neck mucosal melanoma remains a challenge. Surgery has traditionally been the main therapeutic approach. The role of postoperative radiotherapy has never been clearly established.

METHODS

The experience with a group of 42 patients (16 males, 26 females) with a primary head and neck mucosal melanoma is reported.

RESULTS

Eleven of 19 patients (57.9%) receiving surgery alone developed a regional lymphatic metastasis. For patients receiving postoperative radiotherapy (19 patients), regional metastatic spread occurred in 4 patients (21%). Percentages of local failure were 57.9% (11/19) and 26.3% (5/19) for patients treated with surgery alone and for those treated with surgery and radiotherapy, respectively. Distant metastases occurred in 10 of 19 patients (52.6%) receiving surgery alone and in 9 of 19 patients (47.3%) receiving both therapies.

CONCLUSIONS

The present evaluation confirms a poor prognosis for patients with head and neck mucosal melanoma, independent of the treatment modality.

Authors+Show Affiliations

Unit of Oral Pathology and Medicine, Section of Odontostomatology, Department of ENT/Dental/Ophthalmological and Cervico-Facial Sciences, University of Parma, Parma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

18704960

Citation

Meleti, Marco, et al. "Head and Neck Mucosal Melanoma: Experience With 42 Patients, With Emphasis On the Role of Postoperative Radiotherapy." Head & Neck, vol. 30, no. 12, 2008, pp. 1543-51.
Meleti M, Leemans CR, de Bree R, et al. Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy. Head Neck. 2008;30(12):1543-51.
Meleti, M., Leemans, C. R., de Bree, R., Vescovi, P., Sesenna, E., & van der Waal, I. (2008). Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy. Head & Neck, 30(12), 1543-51. https://doi.org/10.1002/hed.20901
Meleti M, et al. Head and Neck Mucosal Melanoma: Experience With 42 Patients, With Emphasis On the Role of Postoperative Radiotherapy. Head Neck. 2008;30(12):1543-51. PubMed PMID: 18704960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy. AU - Meleti,Marco, AU - Leemans,C René, AU - de Bree,Remco, AU - Vescovi,Paolo, AU - Sesenna,Enrico, AU - van der Waal,Isaäc, PY - 2008/8/16/pubmed PY - 2009/2/21/medline PY - 2008/8/16/entrez SP - 1543 EP - 51 JF - Head & neck JO - Head Neck VL - 30 IS - 12 N2 - BACKGROUND: Treatment of head and neck mucosal melanoma remains a challenge. Surgery has traditionally been the main therapeutic approach. The role of postoperative radiotherapy has never been clearly established. METHODS: The experience with a group of 42 patients (16 males, 26 females) with a primary head and neck mucosal melanoma is reported. RESULTS: Eleven of 19 patients (57.9%) receiving surgery alone developed a regional lymphatic metastasis. For patients receiving postoperative radiotherapy (19 patients), regional metastatic spread occurred in 4 patients (21%). Percentages of local failure were 57.9% (11/19) and 26.3% (5/19) for patients treated with surgery alone and for those treated with surgery and radiotherapy, respectively. Distant metastases occurred in 10 of 19 patients (52.6%) receiving surgery alone and in 9 of 19 patients (47.3%) receiving both therapies. CONCLUSIONS: The present evaluation confirms a poor prognosis for patients with head and neck mucosal melanoma, independent of the treatment modality. SN - 1097-0347 UR - https://www.unboundmedicine.com/medline/citation/18704960/Head_and_neck_mucosal_melanoma:_experience_with_42_patients_with_emphasis_on_the_role_of_postoperative_radiotherapy_ L2 - https://doi.org/10.1002/hed.20901 DB - PRIME DP - Unbound Medicine ER -