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Association between the serotonin 1A receptor C(-1019)G polymorphism and major depressive disorder in the northern Han ethnic group in China.
Chin Med J (Engl). 2008 May 20; 121(10):874-6.CM

Abstract

BACKGROUND

Recent studies have suggested that susceptibility to major depressive disorder (MDD) might be related to the serotonin 1A receptor (5-HTR1A) C (-1019) G polymorphism. In this study, we aimed to assess the association between 5-HTR1A C (-1019) G polymorphism and MDD in the Northern Han ethnic group of China.

METHODS

The C (-1019) G of 5-HTR1A was detected with polymerase chain reaction (PCR) in 400 patients with MDD and 400 unrelated age- and sex-matched healthy control subjects. Association between the C (-1019) G and MDD was statistically analyzed.

RESULTS

There was a statistically significant difference between MDD patients and controls in both the genotype distribution (Chi(2) = 10.913, df = 2, P = 0.004) and the allele frequency (Chi(2) = 10.379, df = 1, P = 0.001), and a significant difference in the genotype distribution and the allele frequency was found both in the female subjects (Genotype distribution: Chi(2) = 15.406, df = 2, P = 0.000; allele frequency: Chi(2) = 15.552, df = 1, P = 0.000) and the late-onset subjects (Genotype distribution: Chi(2) = 7.771, df = 2, P = 0.021; allele frequency: Chi(2) = 8.007, df = 1, P = 0.005) in the two groups.

CONCLUSION

These results suggest that 5-HTR1A C (-1019) G polymorphism is probably associated with MDD and it is likely to be the susceptible gene locus for the female and late-onset MDD.

Authors+Show Affiliations

Shanxi Medical University, Taiyuan, Shanxi 030001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18706198

Citation

Wu, Ying, et al. "Association Between the Serotonin 1A Receptor C(-1019)G Polymorphism and Major Depressive Disorder in the Northern Han Ethnic Group in China." Chinese Medical Journal, vol. 121, no. 10, 2008, pp. 874-6.
Wu Y, Xu Y, Sun Y, et al. Association between the serotonin 1A receptor C(-1019)G polymorphism and major depressive disorder in the northern Han ethnic group in China. Chin Med J (Engl). 2008;121(10):874-6.
Wu, Y., Xu, Y., Sun, Y., Wang, Y. F., Li, X., Lang, X. E., Wang, W. P., & Zhang, K. R. (2008). Association between the serotonin 1A receptor C(-1019)G polymorphism and major depressive disorder in the northern Han ethnic group in China. Chinese Medical Journal, 121(10), 874-6.
Wu Y, et al. Association Between the Serotonin 1A Receptor C(-1019)G Polymorphism and Major Depressive Disorder in the Northern Han Ethnic Group in China. Chin Med J (Engl). 2008 May 20;121(10):874-6. PubMed PMID: 18706198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between the serotonin 1A receptor C(-1019)G polymorphism and major depressive disorder in the northern Han ethnic group in China. AU - Wu,Ying, AU - Xu,Yong, AU - Sun,Yan, AU - Wang,Yan-fang, AU - Li,Xia, AU - Lang,Xiao-e, AU - Wang,Wei-ping, AU - Zhang,Ke-rang, PY - 2008/8/19/pubmed PY - 2008/12/17/medline PY - 2008/8/19/entrez SP - 874 EP - 6 JF - Chinese medical journal JO - Chin Med J (Engl) VL - 121 IS - 10 N2 - BACKGROUND: Recent studies have suggested that susceptibility to major depressive disorder (MDD) might be related to the serotonin 1A receptor (5-HTR1A) C (-1019) G polymorphism. In this study, we aimed to assess the association between 5-HTR1A C (-1019) G polymorphism and MDD in the Northern Han ethnic group of China. METHODS: The C (-1019) G of 5-HTR1A was detected with polymerase chain reaction (PCR) in 400 patients with MDD and 400 unrelated age- and sex-matched healthy control subjects. Association between the C (-1019) G and MDD was statistically analyzed. RESULTS: There was a statistically significant difference between MDD patients and controls in both the genotype distribution (Chi(2) = 10.913, df = 2, P = 0.004) and the allele frequency (Chi(2) = 10.379, df = 1, P = 0.001), and a significant difference in the genotype distribution and the allele frequency was found both in the female subjects (Genotype distribution: Chi(2) = 15.406, df = 2, P = 0.000; allele frequency: Chi(2) = 15.552, df = 1, P = 0.000) and the late-onset subjects (Genotype distribution: Chi(2) = 7.771, df = 2, P = 0.021; allele frequency: Chi(2) = 8.007, df = 1, P = 0.005) in the two groups. CONCLUSION: These results suggest that 5-HTR1A C (-1019) G polymorphism is probably associated with MDD and it is likely to be the susceptible gene locus for the female and late-onset MDD. SN - 0366-6999 UR - https://www.unboundmedicine.com/medline/citation/18706198/Association_between_the_serotonin_1A_receptor_C__1019_G_polymorphism_and_major_depressive_disorder_in_the_northern_Han_ethnic_group_in_China_ L2 - https://Insights.ovid.com/pubmed?pmid=18706198 DB - PRIME DP - Unbound Medicine ER -