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Chiral separation by capillary electromigration techniques.
J Chromatogr A. 2008 Sep 19; 1204(2):140-56.JC

Abstract

This review gives an overview of chiral separation principles and their applications in capillary electromigration techniques. The basic chiral separation principles are explained and the mechanisms discussed. Recent developments and new techniques in CZE and capillary electrochromatography (CEC) are highlighted. New chiral selectors among cyclodextrins, crown ethers, carbohydrates, macrocyclic antibiotics, proteins, chiral ion-pairing reagents, chiral surfactants and chiral metal ion complexes and their chiral recognition ability are discussed. Recent advances in chip technology for chiral separation and new approaches regarding improvement of detection sensitivity are presented. Due to the tremendous number of publications dealing with applications, in this review only recent applications are summarized.

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Authors+Show Affiliations

Gübitz G
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Karl-Franzens-University Graz, Universitätsplatz 1, A-8010 Graz, Austria. gerald.guebitz@uni-graz.at
Schmid MG
No affiliation info available

MeSH

AnimalsCapillary ElectrochromatographyElectrophoresis, CapillaryMass SpectrometrySensitivity and SpecificityStereoisomerismWater

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

18706565

Citation

Gübitz, Gerald, and Martin G. Schmid. "Chiral Separation By Capillary Electromigration Techniques." Journal of Chromatography. A, vol. 1204, no. 2, 2008, pp. 140-56.
Gübitz G, Schmid MG. Chiral separation by capillary electromigration techniques. J Chromatogr A. 2008;1204(2):140-56.
Gübitz, G., & Schmid, M. G. (2008). Chiral separation by capillary electromigration techniques. Journal of Chromatography. A, 1204(2), 140-56. https://doi.org/10.1016/j.chroma.2008.07.071
Gübitz G, Schmid MG. Chiral Separation By Capillary Electromigration Techniques. J Chromatogr A. 2008 Sep 19;1204(2):140-56. PubMed PMID: 18706565.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chiral separation by capillary electromigration techniques. AU - Gübitz,Gerald, AU - Schmid,Martin G, Y1 - 2008/07/29/ PY - 2008/01/18/received PY - 2008/06/27/revised PY - 2008/07/08/accepted PY - 2008/8/19/pubmed PY - 2008/10/24/medline PY - 2008/8/19/entrez SP - 140 EP - 56 JF - Journal of chromatography. A JO - J Chromatogr A VL - 1204 IS - 2 N2 - This review gives an overview of chiral separation principles and their applications in capillary electromigration techniques. The basic chiral separation principles are explained and the mechanisms discussed. Recent developments and new techniques in CZE and capillary electrochromatography (CEC) are highlighted. New chiral selectors among cyclodextrins, crown ethers, carbohydrates, macrocyclic antibiotics, proteins, chiral ion-pairing reagents, chiral surfactants and chiral metal ion complexes and their chiral recognition ability are discussed. Recent advances in chip technology for chiral separation and new approaches regarding improvement of detection sensitivity are presented. Due to the tremendous number of publications dealing with applications, in this review only recent applications are summarized. SN - 0021-9673 UR - https://www.unboundmedicine.com/medline/citation/18706565/Chiral_separation_by_capillary_electromigration_techniques_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0021-9673(08)01140-0 DB - PRIME DP - Unbound Medicine ER -