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HDL-cholesterol level provides additional prognosis in acute coronary syndromes.
Int J Cardiol. 2009 Aug 21; 136(3):307-14.IJ

Abstract

In the setting of acute coronary syndromes, plasma lipids have not been defined as prognostic variables, however little research has been dedicated to this specific issue. In order to test the independent predictive value for in-hospital events of low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglycerides measured at hospital admission, 97 individuals with unstable angina or non-ST-elevation acute myocardial infarction were evaluated. In-hospital events, defined as death, non-fatal myocardial infarction or recurrent unstable angina, were significantly predicted by HDL-cholesterol (C-statistics=0.69; 95% CI=0.55-0.83, P=0.018), contrary to LDL-cholesterol (C-statistics=0.40; 95% CI=0.24-0.56, P=0.23) and triglycerides (C-statistics=0.48; 95% CI=0.31-0.65, P=0.83). The best HDL-cholesterol cut-off point was 32 mg/dl, with a 33% incidence of events in patients with HDL-cholesterol < or =32 mg/dl, compared with only 9% in those with HDL-cholesterol>32 mg/dl (P=0.003). Logistic regression analysis showed HDL-cholesterol< or =32 mg/dl (OR=3.6; 95% CI=1.0-14; P=0.05) and TIMI Risk Score (OR=2.3; 95% CI=1.4-2.9, P=0.001) as the independent predictors of events. Furthermore, the addition of HDL-cholesterol to TIMI Risk Score improved its C-statistic from 0.81 to 0.85. In conclusion, as opposed to LDL-cholesterol and triglycerides, HDL-cholesterol level adds prognostic value to the prediction of in-hospital recurrent events during non-ST-elevation acute coronary syndromes.

Authors+Show Affiliations

Portuguese Hospital, Salvador/BA, Brazil. lccorreia@terra.com.brNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18706714

Citation

Correia, Luís C L., et al. "HDL-cholesterol Level Provides Additional Prognosis in Acute Coronary Syndromes." International Journal of Cardiology, vol. 136, no. 3, 2009, pp. 307-14.
Correia LC, Rocha MS, Esteves JP. HDL-cholesterol level provides additional prognosis in acute coronary syndromes. Int J Cardiol. 2009;136(3):307-14.
Correia, L. C., Rocha, M. S., & Esteves, J. P. (2009). HDL-cholesterol level provides additional prognosis in acute coronary syndromes. International Journal of Cardiology, 136(3), 307-14. https://doi.org/10.1016/j.ijcard.2008.05.067
Correia LC, Rocha MS, Esteves JP. HDL-cholesterol Level Provides Additional Prognosis in Acute Coronary Syndromes. Int J Cardiol. 2009 Aug 21;136(3):307-14. PubMed PMID: 18706714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - HDL-cholesterol level provides additional prognosis in acute coronary syndromes. AU - Correia,Luís C L, AU - Rocha,Mário S, AU - Esteves,J Péricles, Y1 - 2008/08/15/ PY - 2008/01/15/received PY - 2008/04/29/revised PY - 2008/05/03/accepted PY - 2008/8/19/pubmed PY - 2009/10/22/medline PY - 2008/8/19/entrez SP - 307 EP - 14 JF - International journal of cardiology JO - Int J Cardiol VL - 136 IS - 3 N2 - In the setting of acute coronary syndromes, plasma lipids have not been defined as prognostic variables, however little research has been dedicated to this specific issue. In order to test the independent predictive value for in-hospital events of low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglycerides measured at hospital admission, 97 individuals with unstable angina or non-ST-elevation acute myocardial infarction were evaluated. In-hospital events, defined as death, non-fatal myocardial infarction or recurrent unstable angina, were significantly predicted by HDL-cholesterol (C-statistics=0.69; 95% CI=0.55-0.83, P=0.018), contrary to LDL-cholesterol (C-statistics=0.40; 95% CI=0.24-0.56, P=0.23) and triglycerides (C-statistics=0.48; 95% CI=0.31-0.65, P=0.83). The best HDL-cholesterol cut-off point was 32 mg/dl, with a 33% incidence of events in patients with HDL-cholesterol < or =32 mg/dl, compared with only 9% in those with HDL-cholesterol>32 mg/dl (P=0.003). Logistic regression analysis showed HDL-cholesterol< or =32 mg/dl (OR=3.6; 95% CI=1.0-14; P=0.05) and TIMI Risk Score (OR=2.3; 95% CI=1.4-2.9, P=0.001) as the independent predictors of events. Furthermore, the addition of HDL-cholesterol to TIMI Risk Score improved its C-statistic from 0.81 to 0.85. In conclusion, as opposed to LDL-cholesterol and triglycerides, HDL-cholesterol level adds prognostic value to the prediction of in-hospital recurrent events during non-ST-elevation acute coronary syndromes. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/18706714/HDL_cholesterol_level_provides_additional_prognosis_in_acute_coronary_syndromes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(08)00737-7 DB - PRIME DP - Unbound Medicine ER -