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Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes.
Biol Psychol. 2008 Dec; 79(3):294-8.BP

Abstract

We investigated dehydroepiandrosterone (DHEA) secretion in response to acute psychosocial stress and the relations of DHEA secretion to cortisol secretion, cardiovascular activity, and negative mood changes. Thirty-three male students (mean age 22.6 years) were subjected to the psychosocial stress test "Trier Social Stress Test" (TSST), in which the participants were asked to deliver a speech and perform a mental arithmetic task in front of two audiences. Collections of saliva, measurements of blood pressure and heart rate, and assessments of negative mood by visual analog scales were conducted before, during, and after TSST. Acute psychosocial stress significantly increased salivary DHEA level by an average of 60% immediately after TSST. The peak of DHEA concentration preceded that of cortisol concentration by about 10 min. DHEA response was moderately correlated to cortisol response (r=.34, r(s)=.49) but not to cardiovascular response. Lower DHEA level and elevated cortisol/DHEA ratio during TSST were significantly and moderately correlated with increased negative mood during and after TSST. These results indicated that an acute increase in DHEA concentration under stressful situations might be partly mediated by the activity of hypothalamus-pituitary-adrenal axis and could have some significance in the improvement of negative mood.

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Authors+Show Affiliations

Izawa S
Institute for Biomedical Engineering, Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, 513 Wasedatsurumaki-cho, Shinjuku-ku, Tokyo 162-0041, Japan. izawa@aoni.waseda.jp
Sugaya N
No affiliation info available
Shirotsuki K
No affiliation info available
Yamada KC
No affiliation info available
Ogawa N
No affiliation info available
Ouchi Y
No affiliation info available
Nagano Y
No affiliation info available
Suzuki K
No affiliation info available
Nomura S
No affiliation info available

MeSH

AdultAnalysis of VarianceBlood PressureDehydroepiandrosteroneHeart RateHumansHydrocortisoneImmunoassayLinear ModelsMaleSalivaStress, PsychologicalYoung Adult

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18706968

Citation

Izawa, Shuhei, et al. "Salivary Dehydroepiandrosterone Secretion in Response to Acute Psychosocial Stress and Its Correlations With Biological and Psychological Changes." Biological Psychology, vol. 79, no. 3, 2008, pp. 294-8.
Izawa S, Sugaya N, Shirotsuki K, et al. Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes. Biol Psychol. 2008;79(3):294-8.
Izawa, S., Sugaya, N., Shirotsuki, K., Yamada, K. C., Ogawa, N., Ouchi, Y., Nagano, Y., Suzuki, K., & Nomura, S. (2008). Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes. Biological Psychology, 79(3), 294-8. https://doi.org/10.1016/j.biopsycho.2008.07.003
Izawa S, et al. Salivary Dehydroepiandrosterone Secretion in Response to Acute Psychosocial Stress and Its Correlations With Biological and Psychological Changes. Biol Psychol. 2008;79(3):294-8. PubMed PMID: 18706968.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Salivary dehydroepiandrosterone secretion in response to acute psychosocial stress and its correlations with biological and psychological changes. AU - Izawa,Shuhei, AU - Sugaya,Nagisa, AU - Shirotsuki,Kentaro, AU - Yamada,Kosuke Chris, AU - Ogawa,Namiko, AU - Ouchi,Yuko, AU - Nagano,Yuichiro, AU - Suzuki,Katsuhiko, AU - Nomura,Shinobu, Y1 - 2008/07/25/ PY - 2007/08/07/received PY - 2008/07/15/revised PY - 2008/07/15/accepted PY - 2008/8/19/pubmed PY - 2009/4/9/medline PY - 2008/8/19/entrez SP - 294 EP - 8 JF - Biological psychology JO - Biol Psychol VL - 79 IS - 3 N2 - We investigated dehydroepiandrosterone (DHEA) secretion in response to acute psychosocial stress and the relations of DHEA secretion to cortisol secretion, cardiovascular activity, and negative mood changes. Thirty-three male students (mean age 22.6 years) were subjected to the psychosocial stress test "Trier Social Stress Test" (TSST), in which the participants were asked to deliver a speech and perform a mental arithmetic task in front of two audiences. Collections of saliva, measurements of blood pressure and heart rate, and assessments of negative mood by visual analog scales were conducted before, during, and after TSST. Acute psychosocial stress significantly increased salivary DHEA level by an average of 60% immediately after TSST. The peak of DHEA concentration preceded that of cortisol concentration by about 10 min. DHEA response was moderately correlated to cortisol response (r=.34, r(s)=.49) but not to cardiovascular response. Lower DHEA level and elevated cortisol/DHEA ratio during TSST were significantly and moderately correlated with increased negative mood during and after TSST. These results indicated that an acute increase in DHEA concentration under stressful situations might be partly mediated by the activity of hypothalamus-pituitary-adrenal axis and could have some significance in the improvement of negative mood. SN - 1873-6246 UR - https://www.unboundmedicine.com/medline/citation/18706968/Salivary_dehydroepiandrosterone_secretion_in_response_to_acute_psychosocial_stress_and_its_correlations_with_biological_and_psychological_changes_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-0511(08)00167-1 DB - PRIME DP - Unbound Medicine ER -