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Alcohol and breast cancer risk defined by estrogen and progesterone receptor status: a case-control study.
Cancer Epidemiol Biomarkers Prev. 2008 Aug; 17(8):2025-8.CE

Abstract

BACKGROUND

Alcohol consumption increases breast cancer risk. Some studies suggested that this association is stronger or limited to tumors expressing estrogen receptors (ER).

METHODS

We investigated the role of alcohol according to ER and progesterone receptor (PR) status in a case-control study on breast cancer conducted from 1991 to 1994 in three Italian areas. Cases were 989 women with incident, histologically confirmed breast cancer. Controls were 1,350 women admitted to hospitals in the same catchment areas for acute nonneoplastic diseases. A validated food-frequency questionnaire was used to collect information on dietary habits and lifetime consumption of various alcoholic beverages. Multiple logistic regression models were used to estimate odds ratios and 95% confidence interval (95% CI).

RESULTS

Alcohol drinking was associated with ER+ tumors (odds ratio, 2.16; 95% CI, 1.68-2.76 for an intake of > or =13.8 g/d as compared with nondrinkers). The odds ratio was 1.13 (95% CI, 1.07-1.20) for a 10-g increase in daily intake. For ER- tumors, the relation with alcohol consumption was not significant (odds ratio, 1.36; 95% CI, 0.93-2.01). When breast cancers were further classified according to PR, the findings for ER+PR+ cancers were similar to those for all ER+ ones, with an odds ratio of 2.34 (95% CI, 1.81-3.04) for an intake of > or =13.8 g/d. No significant association emerged for ER-PR- tumors (odds ratio, 1.25; 95% CI, 0.81-1.94).

CONCLUSION

This study supports the hypothesis that alcohol is more strongly related to ER+ than to ER- breast tumors.

Authors+Show Affiliations

Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa, 19-20156 Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18708394

Citation

Deandrea, Silvia, et al. "Alcohol and Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status: a Case-control Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 8, 2008, pp. 2025-8.
Deandrea S, Talamini R, Foschi R, et al. Alcohol and breast cancer risk defined by estrogen and progesterone receptor status: a case-control study. Cancer Epidemiol Biomarkers Prev. 2008;17(8):2025-8.
Deandrea, S., Talamini, R., Foschi, R., Montella, M., Dal Maso, L., Falcini, F., La Vecchia, C., Franceschi, S., & Negri, E. (2008). Alcohol and breast cancer risk defined by estrogen and progesterone receptor status: a case-control study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(8), 2025-8. https://doi.org/10.1158/1055-9965.EPI-08-0157
Deandrea S, et al. Alcohol and Breast Cancer Risk Defined By Estrogen and Progesterone Receptor Status: a Case-control Study. Cancer Epidemiol Biomarkers Prev. 2008;17(8):2025-8. PubMed PMID: 18708394.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alcohol and breast cancer risk defined by estrogen and progesterone receptor status: a case-control study. AU - Deandrea,Silvia, AU - Talamini,Renato, AU - Foschi,Roberto, AU - Montella,Maurizio, AU - Dal Maso,Luigino, AU - Falcini,Fabio, AU - La Vecchia,Carlo, AU - Franceschi,Silvia, AU - Negri,Eva, PY - 2008/8/19/pubmed PY - 2008/12/17/medline PY - 2008/8/19/entrez SP - 2025 EP - 8 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol. Biomarkers Prev. VL - 17 IS - 8 N2 - BACKGROUND: Alcohol consumption increases breast cancer risk. Some studies suggested that this association is stronger or limited to tumors expressing estrogen receptors (ER). METHODS: We investigated the role of alcohol according to ER and progesterone receptor (PR) status in a case-control study on breast cancer conducted from 1991 to 1994 in three Italian areas. Cases were 989 women with incident, histologically confirmed breast cancer. Controls were 1,350 women admitted to hospitals in the same catchment areas for acute nonneoplastic diseases. A validated food-frequency questionnaire was used to collect information on dietary habits and lifetime consumption of various alcoholic beverages. Multiple logistic regression models were used to estimate odds ratios and 95% confidence interval (95% CI). RESULTS: Alcohol drinking was associated with ER+ tumors (odds ratio, 2.16; 95% CI, 1.68-2.76 for an intake of > or =13.8 g/d as compared with nondrinkers). The odds ratio was 1.13 (95% CI, 1.07-1.20) for a 10-g increase in daily intake. For ER- tumors, the relation with alcohol consumption was not significant (odds ratio, 1.36; 95% CI, 0.93-2.01). When breast cancers were further classified according to PR, the findings for ER+PR+ cancers were similar to those for all ER+ ones, with an odds ratio of 2.34 (95% CI, 1.81-3.04) for an intake of > or =13.8 g/d. No significant association emerged for ER-PR- tumors (odds ratio, 1.25; 95% CI, 0.81-1.94). CONCLUSION: This study supports the hypothesis that alcohol is more strongly related to ER+ than to ER- breast tumors. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18708394/Alcohol_and_breast_cancer_risk_defined_by_estrogen_and_progesterone_receptor_status:_a_case_control_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18708394 DB - PRIME DP - Unbound Medicine ER -