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Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study.
Cancer Epidemiol Biomarkers Prev. 2008 Aug; 17(8):2128-35.CE

Abstract

Several experimental studies have reported that the anticarcinogenic properties of dietary soy play an important role in preventing colorectal cancer. However, few epidemiologic studies have examined this association in general populations and their findings have been inconsistent. We investigated the association between dietary soy and isoflavone intake and incidence of colorectal cancer in a prospective cohort study of 83,063 Japanese men and women, ages 45 to 74 years. Dietary soy and isoflavone intake was measured through a validated food frequency questionnaire in 1995 and 1998. Throughout 2004, a total of 886 cases of colorectal cancer were newly identified (291 proximal colon, 286 distal colon, and 277 rectum). The hazard ratios and 95% confidence intervals (95% CIs) were estimated by fitting a Cox proportional hazards model. The intake of isoflavones, miso soup, and soy food was not associated with colorectal cancer in either men or women. By colorectal cancer subsite, the risk of proximal colon cancer in men decreased with increasing consumption of isoflavones, miso soup, and soy food. Compared with men in the lowest quartiles of isoflavones, miso soup, and soy food intake, the hazard ratios in the highest quartiles were 0.55 (95% CI, 0.33-0.92), 0.72 (95% CI, 0.43-1.21), and 0.51 (95% CI, 0.30-0.87), respectively. The results showed no association for distal colon and rectal cancer in men or for subsites of colorectal cancer in women. These findings suggest that the intake of isoflavones, miso soup, and soy food has no substantial effect on the risk of colorectal cancer in Japanese men and women.

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Authors+Show Affiliations

Akhter M
Epidemiology and Prevention Division, Research Center for Cancer Prevention and Screening, National Cancer Center, 5-1-1 Tsukiji, Chuo-ku, Tokyo 104-0045, Japan.
Inoue M
No affiliation info available
Kurahashi N
No affiliation info available
Iwasaki M
No affiliation info available
Sasazuki S
No affiliation info available
Tsugane S
No affiliation info available
Japan Public Health Center-Based Prospective Study Group
No affiliation info available

MeSH

AgedColorectal NeoplasmsDietFemaleHumansIncidenceIsoflavonesJapanMaleMiddle AgedProportional Hazards ModelsProspective StudiesRisk FactorsSoy FoodsSurveys and Questionnaires

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18708407

Citation

Akhter, Munira, et al. "Dietary Soy and Isoflavone Intake and Risk of Colorectal Cancer in the Japan Public Health Center-based Prospective Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 17, no. 8, 2008, pp. 2128-35.
Akhter M, Inoue M, Kurahashi N, et al. Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study. Cancer Epidemiol Biomarkers Prev. 2008;17(8):2128-35.
Akhter, M., Inoue, M., Kurahashi, N., Iwasaki, M., Sasazuki, S., & Tsugane, S. (2008). Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 17(8), 2128-35. https://doi.org/10.1158/1055-9965.EPI-08-0182
Akhter M, et al. Dietary Soy and Isoflavone Intake and Risk of Colorectal Cancer in the Japan Public Health Center-based Prospective Study. Cancer Epidemiol Biomarkers Prev. 2008;17(8):2128-35. PubMed PMID: 18708407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary soy and isoflavone intake and risk of colorectal cancer in the Japan public health center-based prospective study. AU - Akhter,Munira, AU - Inoue,Manami, AU - Kurahashi,Norie, AU - Iwasaki,Motoki, AU - Sasazuki,Shizuka, AU - Tsugane,Shoichiro, AU - ,, PY - 2008/8/19/pubmed PY - 2008/12/17/medline PY - 2008/8/19/entrez SP - 2128 EP - 35 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 17 IS - 8 N2 - Several experimental studies have reported that the anticarcinogenic properties of dietary soy play an important role in preventing colorectal cancer. However, few epidemiologic studies have examined this association in general populations and their findings have been inconsistent. We investigated the association between dietary soy and isoflavone intake and incidence of colorectal cancer in a prospective cohort study of 83,063 Japanese men and women, ages 45 to 74 years. Dietary soy and isoflavone intake was measured through a validated food frequency questionnaire in 1995 and 1998. Throughout 2004, a total of 886 cases of colorectal cancer were newly identified (291 proximal colon, 286 distal colon, and 277 rectum). The hazard ratios and 95% confidence intervals (95% CIs) were estimated by fitting a Cox proportional hazards model. The intake of isoflavones, miso soup, and soy food was not associated with colorectal cancer in either men or women. By colorectal cancer subsite, the risk of proximal colon cancer in men decreased with increasing consumption of isoflavones, miso soup, and soy food. Compared with men in the lowest quartiles of isoflavones, miso soup, and soy food intake, the hazard ratios in the highest quartiles were 0.55 (95% CI, 0.33-0.92), 0.72 (95% CI, 0.43-1.21), and 0.51 (95% CI, 0.30-0.87), respectively. The results showed no association for distal colon and rectal cancer in men or for subsites of colorectal cancer in women. These findings suggest that the intake of isoflavones, miso soup, and soy food has no substantial effect on the risk of colorectal cancer in Japanese men and women. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/18708407/Dietary_soy_and_isoflavone_intake_and_risk_of_colorectal_cancer_in_the_Japan_public_health_center_based_prospective_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&pmid=18708407 DB - PRIME DP - Unbound Medicine ER -