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Prenatal phenol and phthalate exposures and birth outcomes.
Environ Health Perspect. 2008 Aug; 116(8):1092-7.EH

Abstract

BACKGROUND

Many phthalates and phenols are hormonally active and are suspected to alter the course of development.

OBJECTIVE

We investigated prenatal exposures to phthalate and phenol metabolites and their associations with body size measures of the infants at birth.

METHODS

We measured 5 phenol and 10 phthalate urinary metabolites in a multiethnic cohort of 404 women in New York City during their third trimester of pregnancy and recorded size of infants at birth.

RESULTS

Median urinary concentrations were > 10 microg/L for 2 of 5 phenols and 6 of 10 phthalate monoester metabolites. Concentrations of low-molecular-weight phthalate monoesters (low-MWP) were approximately 5-fold greater than those of high-molecular-weight metabolites. Low-MWP metabolites had a positive association with gestational age [0.97 day gestational age per ln-biomarker; 95% confidence interval (CI), 0.07-1.9 days, multivariate adjusted] and with head circumference. Higher prenatal exposures to 2,5-dichlorophenol (2,5-DCP) predicted lower birth weight in boys (-210 g average birth weight difference between the third tertile and first tertile of 2,5-DCP; 95% CI, 71-348 g). Higher maternal benzophenone-3 (BP3) concentrations were associated with a similar decrease in birth weight among girls but with greater birth weight in boys.

CONCLUSIONS

We observed a range of phthalate and phenol exposures during pregnancy in our population, but few were associated with birth size. The association of 2,5-DCP and BP3 with reduced or increased birth weight could be important in very early or small-size births. In addition, positive associations of urinary metabolites with some outcomes may be attributable partly to unresolved confounding with maternal anthropometric factors.

Authors+Show Affiliations

Department of Community and Preventive Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA. mary.wolff@mssm.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

18709157

Citation

Wolff, Mary S., et al. "Prenatal Phenol and Phthalate Exposures and Birth Outcomes." Environmental Health Perspectives, vol. 116, no. 8, 2008, pp. 1092-7.
Wolff MS, Engel SM, Berkowitz GS, et al. Prenatal phenol and phthalate exposures and birth outcomes. Environ Health Perspect. 2008;116(8):1092-7.
Wolff, M. S., Engel, S. M., Berkowitz, G. S., Ye, X., Silva, M. J., Zhu, C., Wetmur, J., & Calafat, A. M. (2008). Prenatal phenol and phthalate exposures and birth outcomes. Environmental Health Perspectives, 116(8), 1092-7. https://doi.org/10.1289/ehp.11007
Wolff MS, et al. Prenatal Phenol and Phthalate Exposures and Birth Outcomes. Environ Health Perspect. 2008;116(8):1092-7. PubMed PMID: 18709157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prenatal phenol and phthalate exposures and birth outcomes. AU - Wolff,Mary S, AU - Engel,Stephanie M, AU - Berkowitz,Gertrud S, AU - Ye,Xiaoyun, AU - Silva,Manori J, AU - Zhu,Chenbo, AU - Wetmur,James, AU - Calafat,Antonia M, PY - 2007/10/22/received PY - 2008/03/20/accepted PY - 2008/8/19/pubmed PY - 2008/9/11/medline PY - 2008/8/19/entrez KW - 2,5-DCP KW - BMI KW - birth length KW - birth weight KW - creatinine KW - phenols KW - phthalates KW - pregnancy KW - urinary biomarker SP - 1092 EP - 7 JF - Environmental health perspectives JO - Environ Health Perspect VL - 116 IS - 8 N2 - BACKGROUND: Many phthalates and phenols are hormonally active and are suspected to alter the course of development. OBJECTIVE: We investigated prenatal exposures to phthalate and phenol metabolites and their associations with body size measures of the infants at birth. METHODS: We measured 5 phenol and 10 phthalate urinary metabolites in a multiethnic cohort of 404 women in New York City during their third trimester of pregnancy and recorded size of infants at birth. RESULTS: Median urinary concentrations were > 10 microg/L for 2 of 5 phenols and 6 of 10 phthalate monoester metabolites. Concentrations of low-molecular-weight phthalate monoesters (low-MWP) were approximately 5-fold greater than those of high-molecular-weight metabolites. Low-MWP metabolites had a positive association with gestational age [0.97 day gestational age per ln-biomarker; 95% confidence interval (CI), 0.07-1.9 days, multivariate adjusted] and with head circumference. Higher prenatal exposures to 2,5-dichlorophenol (2,5-DCP) predicted lower birth weight in boys (-210 g average birth weight difference between the third tertile and first tertile of 2,5-DCP; 95% CI, 71-348 g). Higher maternal benzophenone-3 (BP3) concentrations were associated with a similar decrease in birth weight among girls but with greater birth weight in boys. CONCLUSIONS: We observed a range of phthalate and phenol exposures during pregnancy in our population, but few were associated with birth size. The association of 2,5-DCP and BP3 with reduced or increased birth weight could be important in very early or small-size births. In addition, positive associations of urinary metabolites with some outcomes may be attributable partly to unresolved confounding with maternal anthropometric factors. SN - 0091-6765 UR - https://www.unboundmedicine.com/medline/citation/18709157/Prenatal_phenol_and_phthalate_exposures_and_birth_outcomes_ L2 - https://ehp.niehs.nih.gov/doi/10.1289/ehp.11007?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -