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Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease.
J Neurosci Res. 2008 Dec; 86(16):3622-34.JN

Abstract

To find effective agents for Parkinson's disease (PD) prevention and therapy, we examined the protective effects of the polyhydroxylated fullerene derivative C(60)(OH)(24) in a 1-methyl-4-phenylpyridinium (MPP(+)) -induced acute cellular PD model in human neuroblastoma cells and the free radical scavenging effects in this model with an electron spin resonance (ESR) spectrometer. Pretreatment with C(60)(OH)(24) at concentrations greater than 20 microM showed significant protective effects on MPP(+) -induced loss in cell viability, decreases in mitochondrial function (including mitochondrial membrane potential and activities of complex I and II), and increases in the levels of reactive oxygen species and oxidative damage to DNA and proteins. In addition, C(60)(OH)(24) acts as a phase 2 enzyme inducer to protect cells from MPP(+) -induced decreases in expression of nuclear factor-E2-related factor 2, expression and activity of gamma-glutamyl cysteine ligase and level of glutathione. The ESR study showed that C(60)(OH)(24) is a powerful radical scavenger for superoxide, hydroxyl, and lipid radicals. These data suggest that C(60)(OH)(24) is a mitochondrial protective antioxidant with direct radical scavenging activity and indirect antioxidant inducing activity.

Authors+Show Affiliations

Laboratory of Nanobiology and Medicine, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18709653

Citation

Cai, Xiaoqing, et al. "Polyhydroxylated Fullerene Derivative C(60)(OH)(24) Prevents Mitochondrial Dysfunction and Oxidative Damage in an MPP(+) -induced Cellular Model of Parkinson's Disease." Journal of Neuroscience Research, vol. 86, no. 16, 2008, pp. 3622-34.
Cai X, Jia H, Liu Z, et al. Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease. J Neurosci Res. 2008;86(16):3622-34.
Cai, X., Jia, H., Liu, Z., Hou, B., Luo, C., Feng, Z., Li, W., & Liu, J. (2008). Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease. Journal of Neuroscience Research, 86(16), 3622-34. https://doi.org/10.1002/jnr.21805
Cai X, et al. Polyhydroxylated Fullerene Derivative C(60)(OH)(24) Prevents Mitochondrial Dysfunction and Oxidative Damage in an MPP(+) -induced Cellular Model of Parkinson's Disease. J Neurosci Res. 2008;86(16):3622-34. PubMed PMID: 18709653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyhydroxylated fullerene derivative C(60)(OH)(24) prevents mitochondrial dysfunction and oxidative damage in an MPP(+) -induced cellular model of Parkinson's disease. AU - Cai,Xiaoqing, AU - Jia,Haiqun, AU - Liu,Zhongbo, AU - Hou,Bei, AU - Luo,Cheng, AU - Feng,Zhihui, AU - Li,Wenxin, AU - Liu,Jiankang, PY - 2008/8/19/pubmed PY - 2009/2/20/medline PY - 2008/8/19/entrez SP - 3622 EP - 34 JF - Journal of neuroscience research JO - J Neurosci Res VL - 86 IS - 16 N2 - To find effective agents for Parkinson's disease (PD) prevention and therapy, we examined the protective effects of the polyhydroxylated fullerene derivative C(60)(OH)(24) in a 1-methyl-4-phenylpyridinium (MPP(+)) -induced acute cellular PD model in human neuroblastoma cells and the free radical scavenging effects in this model with an electron spin resonance (ESR) spectrometer. Pretreatment with C(60)(OH)(24) at concentrations greater than 20 microM showed significant protective effects on MPP(+) -induced loss in cell viability, decreases in mitochondrial function (including mitochondrial membrane potential and activities of complex I and II), and increases in the levels of reactive oxygen species and oxidative damage to DNA and proteins. In addition, C(60)(OH)(24) acts as a phase 2 enzyme inducer to protect cells from MPP(+) -induced decreases in expression of nuclear factor-E2-related factor 2, expression and activity of gamma-glutamyl cysteine ligase and level of glutathione. The ESR study showed that C(60)(OH)(24) is a powerful radical scavenger for superoxide, hydroxyl, and lipid radicals. These data suggest that C(60)(OH)(24) is a mitochondrial protective antioxidant with direct radical scavenging activity and indirect antioxidant inducing activity. SN - 1097-4547 UR - https://www.unboundmedicine.com/medline/citation/18709653/Polyhydroxylated_fullerene_derivative_C_60__OH__24__prevents_mitochondrial_dysfunction_and_oxidative_damage_in_an_MPP_+___induced_cellular_model_of_Parkinson's_disease_ L2 - https://doi.org/10.1002/jnr.21805 DB - PRIME DP - Unbound Medicine ER -