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The p75 receptor is associated with inflammatory thermal hypersensitivity.
J Neurosci Res. 2008 Dec; 86(16):3566-74.JN

Abstract

Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through the actions of inflammatory mediators, and one of the key molecules is nerve growth factor (NGF). Here we report that the administration of neutralizing antibody to the neurotrophin receptor p75 (p75(NTR)) blocks hyperalgesia, which develops with complete Freund's adjuvant (CFA)-induced inflammation or with an intraplantar injection of NGF. Although CFA injection results in the up-regulation of calcitonin gene-related peptide (CGRP) levels in the primary sensory neurons, blocking p75(NTR) abolishes this effect. We further demonstrate that pro-NGF is the predominant ligand of p75(NTR) in vivo. Plasmin treatment, which is intended to decompose pro-NGF, ameliorates CFA-induced hyperalgesia. In addition, an intraplantar injection of pro-NGF induces hyperalgesia. These data together suggest that pro-NGF, as well as mature NGF, binding to p75(NTR) plays an important role in inflammation-induced hyperalgesia. Interference in the binding may provide a therapeutic approach for the treatment of inflammatory pain.

Authors+Show Affiliations

Department of Neurobiology, Graduate School of Medicine, Chiba University, Chiba, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18709654

Citation

Watanabe, Tomoko, et al. "The P75 Receptor Is Associated With Inflammatory Thermal Hypersensitivity." Journal of Neuroscience Research, vol. 86, no. 16, 2008, pp. 3566-74.
Watanabe T, Ito T, Inoue G, et al. The p75 receptor is associated with inflammatory thermal hypersensitivity. J Neurosci Res. 2008;86(16):3566-74.
Watanabe, T., Ito, T., Inoue, G., Ohtori, S., Kitajo, K., Doya, H., Takahashi, K., & Yamashita, T. (2008). The p75 receptor is associated with inflammatory thermal hypersensitivity. Journal of Neuroscience Research, 86(16), 3566-74. https://doi.org/10.1002/jnr.21808
Watanabe T, et al. The P75 Receptor Is Associated With Inflammatory Thermal Hypersensitivity. J Neurosci Res. 2008;86(16):3566-74. PubMed PMID: 18709654.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The p75 receptor is associated with inflammatory thermal hypersensitivity. AU - Watanabe,Tomoko, AU - Ito,Toshinori, AU - Inoue,Gen, AU - Ohtori,Seiji, AU - Kitajo,Keiko, AU - Doya,Hideo, AU - Takahashi,Kazuhisa, AU - Yamashita,Toshihide, PY - 2008/8/19/pubmed PY - 2009/2/20/medline PY - 2008/8/19/entrez SP - 3566 EP - 74 JF - Journal of neuroscience research JO - J Neurosci Res VL - 86 IS - 16 N2 - Inflammatory pain, characterized by a decrease in the nociceptive threshold, arises through the actions of inflammatory mediators, and one of the key molecules is nerve growth factor (NGF). Here we report that the administration of neutralizing antibody to the neurotrophin receptor p75 (p75(NTR)) blocks hyperalgesia, which develops with complete Freund's adjuvant (CFA)-induced inflammation or with an intraplantar injection of NGF. Although CFA injection results in the up-regulation of calcitonin gene-related peptide (CGRP) levels in the primary sensory neurons, blocking p75(NTR) abolishes this effect. We further demonstrate that pro-NGF is the predominant ligand of p75(NTR) in vivo. Plasmin treatment, which is intended to decompose pro-NGF, ameliorates CFA-induced hyperalgesia. In addition, an intraplantar injection of pro-NGF induces hyperalgesia. These data together suggest that pro-NGF, as well as mature NGF, binding to p75(NTR) plays an important role in inflammation-induced hyperalgesia. Interference in the binding may provide a therapeutic approach for the treatment of inflammatory pain. SN - 1097-4547 UR - https://www.unboundmedicine.com/medline/citation/18709654/The_p75_receptor_is_associated_with_inflammatory_thermal_hypersensitivity_ DB - PRIME DP - Unbound Medicine ER -