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National food-fortification program with folic acid in Chile.
Food Nutr Bull. 2008 Jun; 29(2 Suppl):S231-7.FN

Abstract

The Chilean Ministry of Health legislated to add folic acid (2.2 mg/100 g) to wheat flour to reduce the risk of neural tube defects (NTD), beginning in January 2000. This policy resulted in a significant increase in serum and red blood cell folate in women of childbearing age 1 year after fortification. The frequency of NTD was studied in all births, both live and stillbirths, in a prospective hospital-based design including 25% of national births during 1999-2000 (prefortification period) and 2001-2002 (postfortification period). During the prefortification period, there was a total of 120,566 newborns, and the NTD rate was 17.1/10,000 births. During the postfortification period (2001-2002) there was a total of 117,704 newborns, and the NTD rate was significantly reduced by 43% to 9.7/10,000 births (RR = 0.57; 95% CI, 0.45 to 0.71). This implies a reduction of 43% in the rate of NTD. The costs per NTD case and infant death averted were 1,200 international dollars (I$) and I$11,000, respectively. The cost per disability-adjusted life year (DALY) averted was I$91, or 0.8% of the country's per capita GDP. On the overall, fortification resulted in net cost savings of I$1.8 million. Fortification of wheat flour with folic acid has proven to be an effective and cost saving strategy for the primary prevention of NTD in a middle-income country in a postepidemiological transition, and in a dramatically short period of time.

Authors+Show Affiliations

Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. ehertram@inta.clNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18709898

Citation

Hertrampf, Eva, and Fanny Cortés. "National Food-fortification Program With Folic Acid in Chile." Food and Nutrition Bulletin, vol. 29, no. 2 Suppl, 2008, pp. S231-7.
Hertrampf E, Cortés F. National food-fortification program with folic acid in Chile. Food Nutr Bull. 2008;29(2 Suppl):S231-7.
Hertrampf, E., & Cortés, F. (2008). National food-fortification program with folic acid in Chile. Food and Nutrition Bulletin, 29(2 Suppl), S231-7.
Hertrampf E, Cortés F. National Food-fortification Program With Folic Acid in Chile. Food Nutr Bull. 2008;29(2 Suppl):S231-7. PubMed PMID: 18709898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - National food-fortification program with folic acid in Chile. AU - Hertrampf,Eva, AU - Cortés,Fanny, PY - 2008/8/20/pubmed PY - 2008/11/11/medline PY - 2008/8/20/entrez SP - S231 EP - 7 JF - Food and nutrition bulletin JO - Food Nutr Bull VL - 29 IS - 2 Suppl N2 - The Chilean Ministry of Health legislated to add folic acid (2.2 mg/100 g) to wheat flour to reduce the risk of neural tube defects (NTD), beginning in January 2000. This policy resulted in a significant increase in serum and red blood cell folate in women of childbearing age 1 year after fortification. The frequency of NTD was studied in all births, both live and stillbirths, in a prospective hospital-based design including 25% of national births during 1999-2000 (prefortification period) and 2001-2002 (postfortification period). During the prefortification period, there was a total of 120,566 newborns, and the NTD rate was 17.1/10,000 births. During the postfortification period (2001-2002) there was a total of 117,704 newborns, and the NTD rate was significantly reduced by 43% to 9.7/10,000 births (RR = 0.57; 95% CI, 0.45 to 0.71). This implies a reduction of 43% in the rate of NTD. The costs per NTD case and infant death averted were 1,200 international dollars (I$) and I$11,000, respectively. The cost per disability-adjusted life year (DALY) averted was I$91, or 0.8% of the country's per capita GDP. On the overall, fortification resulted in net cost savings of I$1.8 million. Fortification of wheat flour with folic acid has proven to be an effective and cost saving strategy for the primary prevention of NTD in a middle-income country in a postepidemiological transition, and in a dramatically short period of time. SN - 0379-5721 UR - https://www.unboundmedicine.com/medline/citation/18709898/National_food_fortification_program_with_folic_acid_in_Chile_ L2 - http://journals.sagepub.com/doi/full/10.1177/15648265080292S128?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -