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Clinical trial: gluten microchallenge with wheat-based starch hydrolysates in coeliac disease patients - a randomized, double-blind, placebo-controlled study to evaluate safety.
Aliment Pharmacol Ther. 2008 Nov 15; 28(10):1240-8.AP

Abstract

BACKGROUND

Wheat-based starch hydrolysates such as glucose syrups, dextrose and maltodextrins are found in more than 50% of European processed food. These products contain low amounts of residual gluten and it has been questioned whether they are safe for coeliac disease patients.

AIM

To investigate whether coeliac disease patients can safely consume wheat-based starch hydrolysate products.

METHODS

This randomized, double-blind, placebo-controlled, prospective follow-up study involved 90 coeliac disease patients in remission randomized to consume glucose syrups, maltodextrins or placebo for 24 weeks. Small bowel mucosal morphology and inflammation, symptoms, coeliac serology and malabsorption laboratory data were evaluated at baseline and at the end of the study.

RESULTS

Daily ingestion of wheat-based starch hydrolysates, glucose syrups and maltodextrins, had no deleterious effect on small-bowel mucosal villous architecture or inflammation in coeliac disease patients when compared to the placebo group. Neither were there any significant differences in gastrointestinal symptoms, serology or malabsorption parameters after 24 weeks.

CONCLUSIONS

Wheat-based starch hydrolysates, glucose syrups and maltodextrins did not have harmful effect on coeliac disease patients. Coeliac patients can thus safely continue to consume these products.

Authors+Show Affiliations

Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, and Medical School, University of Tampere, Tampere, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18710436

Citation

Kaukinen, K, et al. "Clinical Trial: Gluten Microchallenge With Wheat-based Starch Hydrolysates in Coeliac Disease Patients - a Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety." Alimentary Pharmacology & Therapeutics, vol. 28, no. 10, 2008, pp. 1240-8.
Kaukinen K, Salmi T, Collin P, et al. Clinical trial: gluten microchallenge with wheat-based starch hydrolysates in coeliac disease patients - a randomized, double-blind, placebo-controlled study to evaluate safety. Aliment Pharmacol Ther. 2008;28(10):1240-8.
Kaukinen, K., Salmi, T., Collin, P., Huhtala, H., Kärjä-Lahdensuu, T., & Mäki, M. (2008). Clinical trial: gluten microchallenge with wheat-based starch hydrolysates in coeliac disease patients - a randomized, double-blind, placebo-controlled study to evaluate safety. Alimentary Pharmacology & Therapeutics, 28(10), 1240-8. https://doi.org/10.1111/j.1365-2036.2008.03832.x
Kaukinen K, et al. Clinical Trial: Gluten Microchallenge With Wheat-based Starch Hydrolysates in Coeliac Disease Patients - a Randomized, Double-blind, Placebo-controlled Study to Evaluate Safety. Aliment Pharmacol Ther. 2008 Nov 15;28(10):1240-8. PubMed PMID: 18710436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical trial: gluten microchallenge with wheat-based starch hydrolysates in coeliac disease patients - a randomized, double-blind, placebo-controlled study to evaluate safety. AU - Kaukinen,K, AU - Salmi,T, AU - Collin,P, AU - Huhtala,H, AU - Kärjä-Lahdensuu,T, AU - Mäki,M, Y1 - 2008/08/17/ PY - 2008/8/20/pubmed PY - 2009/2/21/medline PY - 2008/8/20/entrez SP - 1240 EP - 8 JF - Alimentary pharmacology & therapeutics JO - Aliment Pharmacol Ther VL - 28 IS - 10 N2 - BACKGROUND: Wheat-based starch hydrolysates such as glucose syrups, dextrose and maltodextrins are found in more than 50% of European processed food. These products contain low amounts of residual gluten and it has been questioned whether they are safe for coeliac disease patients. AIM: To investigate whether coeliac disease patients can safely consume wheat-based starch hydrolysate products. METHODS: This randomized, double-blind, placebo-controlled, prospective follow-up study involved 90 coeliac disease patients in remission randomized to consume glucose syrups, maltodextrins or placebo for 24 weeks. Small bowel mucosal morphology and inflammation, symptoms, coeliac serology and malabsorption laboratory data were evaluated at baseline and at the end of the study. RESULTS: Daily ingestion of wheat-based starch hydrolysates, glucose syrups and maltodextrins, had no deleterious effect on small-bowel mucosal villous architecture or inflammation in coeliac disease patients when compared to the placebo group. Neither were there any significant differences in gastrointestinal symptoms, serology or malabsorption parameters after 24 weeks. CONCLUSIONS: Wheat-based starch hydrolysates, glucose syrups and maltodextrins did not have harmful effect on coeliac disease patients. Coeliac patients can thus safely continue to consume these products. SN - 1365-2036 UR - https://www.unboundmedicine.com/medline/citation/18710436/Clinical_trial:_gluten_microchallenge_with_wheat_based_starch_hydrolysates_in_coeliac_disease_patients___a_randomized_double_blind_placebo_controlled_study_to_evaluate_safety_ L2 - https://doi.org/10.1111/j.1365-2036.2008.03832.x DB - PRIME DP - Unbound Medicine ER -