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The relevance of urodynamic studies for Urge syndrome and dysfunctional voiding: a multicenter controlled trial in children.
J Urol. 2008 Oct; 180(4):1486-93; discussion 1494-5.JU

Abstract

PURPOSE

The objective of this study was to compare prospectively, in urge syndrome and dysfunctional voiding, clinical patterns with urodynamic patterns, to assess changes in urodynamic patterns after treatment, and to correlate urodynamic patterns and parameters with treatment outcome.

MATERIALS AND METHODS

In the European Bladder Dysfunction Study 97 children with clinically diagnosed urge syndrome received standard treatment, to which was randomly added placebo, oxybutynin or bladder training with online feedback. In a separate branch 105 children with clinically diagnosed dysfunctional voiding were randomly allocated to standard treatment or standard treatment plus pelvic floor training with online feedback. In all children urodynamic studies were performed before and immediately after treatment.

RESULTS

In urge syndrome detrusor overactivity was present in 33% of cases before and 27% after treatment (of which 65% were de novo). Detrusor overactivity did not correlate with treatment outcome. In dysfunctional voiding increased pelvic floor activity during voiding, which was present in 67% of cases before and 56% after treatment (of which 45% were de novo), did not correlate with treatment outcome. In urge syndrome as well as in dysfunctional voiding neither maximum detrusor pressure during voiding, cystometric bladder capacity, bladder compliance nor free flow patterns correlated with treatment outcome.

CONCLUSIONS

Neither detrusor overactivity nor increased pelvic floor activity during voiding correlated with treatment outcome. Standard treatment could be the first choice in urge syndrome as well as in dysfunctional voiding, reserving urodynamic studies for patients in whom this first approach fails.

Authors+Show Affiliations

Department of Pediatrics, Antwerp University Hospital, Antwerp, Belgium. anbael@attglobal.netNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18710726

Citation

Bael, An, et al. "The Relevance of Urodynamic Studies for Urge Syndrome and Dysfunctional Voiding: a Multicenter Controlled Trial in Children." The Journal of Urology, vol. 180, no. 4, 2008, pp. 1486-93; discussion 1494-5.
Bael A, Lax H, de Jong TP, et al. The relevance of urodynamic studies for Urge syndrome and dysfunctional voiding: a multicenter controlled trial in children. J Urol. 2008;180(4):1486-93; discussion 1494-5.
Bael, A., Lax, H., de Jong, T. P., Hoebeke, P., Nijman, R. J., Sixt, R., Verhulst, J., Hirche, H., & van Gool, J. D. (2008). The relevance of urodynamic studies for Urge syndrome and dysfunctional voiding: a multicenter controlled trial in children. The Journal of Urology, 180(4), 1486-93; discussion 1494-5. https://doi.org/10.1016/j.juro.2008.06.054
Bael A, et al. The Relevance of Urodynamic Studies for Urge Syndrome and Dysfunctional Voiding: a Multicenter Controlled Trial in Children. J Urol. 2008;180(4):1486-93; discussion 1494-5. PubMed PMID: 18710726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relevance of urodynamic studies for Urge syndrome and dysfunctional voiding: a multicenter controlled trial in children. AU - Bael,An, AU - Lax,Hildegard, AU - de Jong,Tom P V M, AU - Hoebeke,Piet, AU - Nijman,Rien J M, AU - Sixt,Rune, AU - Verhulst,John, AU - Hirche,Herbert, AU - van Gool,Jan D, AU - ,, Y1 - 2008/08/16/ PY - 2008/02/15/received PY - 2008/8/20/pubmed PY - 2008/10/1/medline PY - 2008/8/20/entrez SP - 1486-93; discussion 1494-5 JF - The Journal of urology JO - J Urol VL - 180 IS - 4 N2 - PURPOSE: The objective of this study was to compare prospectively, in urge syndrome and dysfunctional voiding, clinical patterns with urodynamic patterns, to assess changes in urodynamic patterns after treatment, and to correlate urodynamic patterns and parameters with treatment outcome. MATERIALS AND METHODS: In the European Bladder Dysfunction Study 97 children with clinically diagnosed urge syndrome received standard treatment, to which was randomly added placebo, oxybutynin or bladder training with online feedback. In a separate branch 105 children with clinically diagnosed dysfunctional voiding were randomly allocated to standard treatment or standard treatment plus pelvic floor training with online feedback. In all children urodynamic studies were performed before and immediately after treatment. RESULTS: In urge syndrome detrusor overactivity was present in 33% of cases before and 27% after treatment (of which 65% were de novo). Detrusor overactivity did not correlate with treatment outcome. In dysfunctional voiding increased pelvic floor activity during voiding, which was present in 67% of cases before and 56% after treatment (of which 45% were de novo), did not correlate with treatment outcome. In urge syndrome as well as in dysfunctional voiding neither maximum detrusor pressure during voiding, cystometric bladder capacity, bladder compliance nor free flow patterns correlated with treatment outcome. CONCLUSIONS: Neither detrusor overactivity nor increased pelvic floor activity during voiding correlated with treatment outcome. Standard treatment could be the first choice in urge syndrome as well as in dysfunctional voiding, reserving urodynamic studies for patients in whom this first approach fails. SN - 1527-3792 UR - https://www.unboundmedicine.com/medline/citation/18710726/The_relevance_of_urodynamic_studies_for_Urge_syndrome_and_dysfunctional_voiding:_a_multicenter_controlled_trial_in_children_ L2 - https://www.jurology.com/doi/10.1016/j.juro.2008.06.054?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -