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Serum 25-hydroxyvitamin D concentrations and risk for hip fractures.
Ann Intern Med. 2008 Aug 19; 149(4):242-50.AIM

Abstract

BACKGROUND

The relationship between serum 25-hydroxyvitamin D [25(OH) vitamin D] concentration and hip fractures is unclear.

OBJECTIVE

To see whether low serum 25(OH) vitamin D concentrations are associated with hip fractures in community-dwelling women.

DESIGN

Nested case-control study.

SETTING

40 clinical centers in the United States.

PARTICIPANTS

400 case-patients with incident hip fracture and 400 control participants matched on the basis of age, race or ethnicity, and date of blood draw. Both groups were selected from 39 795 postmenopausal women who were not using estrogens or other bone-active therapies and who had not had a previous hip fracture.

MEASUREMENTS

Serum 25(OH) vitamin D was measured and patients were followed for a median of 7.1 years (range, 0.7 to 9.3 years) to assess fractures.

RESULTS

Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]). Women with the lowest 25(OH) vitamin D concentrations (< or =47.5 nmol/L) had a higher fracture risk than did those with the highest concentrations (> or =70.7 nmol/L) (adjusted odds ratio, 1.71 [CI, 1.05 to 2.79]), and the risk increased statistically significantly across quartiles of serum 25(OH) vitamin D concentration (P for trend = 0.016). This association was independent of number of falls, physical function, frailty, renal function, and sex-steroid hormone levels and seemed to be partially mediated by bone resorption.

LIMITATIONS

Few case-patients were nonwhite women. Bone mineral density and parathyroid hormone levels were not accounted for in the analysis.

CONCLUSION

Low serum 25(OH) vitamin D concentrations are associated with a higher risk for hip fracture.

Authors+Show Affiliations

University of Pittsburgh, Department of Epidemiology, 130 DeSoto Street, Crabtree A524, Pittsburgh, PA 15261, USA. jcauley@edc.pitt.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

18711154

Citation

Cauley, Jane A., et al. "Serum 25-hydroxyvitamin D Concentrations and Risk for Hip Fractures." Annals of Internal Medicine, vol. 149, no. 4, 2008, pp. 242-50.
Cauley JA, Lacroix AZ, Wu L, et al. Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Ann Intern Med. 2008;149(4):242-50.
Cauley, J. A., Lacroix, A. Z., Wu, L., Horwitz, M., Danielson, M. E., Bauer, D. C., Lee, J. S., Jackson, R. D., Robbins, J. A., Wu, C., Stanczyk, F. Z., LeBoff, M. S., Wactawski-Wende, J., Sarto, G., Ockene, J., & Cummings, S. R. (2008). Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. Annals of Internal Medicine, 149(4), 242-50.
Cauley JA, et al. Serum 25-hydroxyvitamin D Concentrations and Risk for Hip Fractures. Ann Intern Med. 2008 Aug 19;149(4):242-50. PubMed PMID: 18711154.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum 25-hydroxyvitamin D concentrations and risk for hip fractures. AU - Cauley,Jane A, AU - Lacroix,Andrea Z, AU - Wu,LieLing, AU - Horwitz,Mara, AU - Danielson,Michelle E, AU - Bauer,Doug C, AU - Lee,Jennifer S, AU - Jackson,Rebecca D, AU - Robbins,John A, AU - Wu,Chunyuan, AU - Stanczyk,Frank Z, AU - LeBoff,Meryl S, AU - Wactawski-Wende,Jean, AU - Sarto,Gloria, AU - Ockene,Judith, AU - Cummings,Steven R, PY - 2008/8/20/pubmed PY - 2008/8/23/medline PY - 2008/8/20/entrez SP - 242 EP - 50 JF - Annals of internal medicine JO - Ann Intern Med VL - 149 IS - 4 N2 - BACKGROUND: The relationship between serum 25-hydroxyvitamin D [25(OH) vitamin D] concentration and hip fractures is unclear. OBJECTIVE: To see whether low serum 25(OH) vitamin D concentrations are associated with hip fractures in community-dwelling women. DESIGN: Nested case-control study. SETTING: 40 clinical centers in the United States. PARTICIPANTS: 400 case-patients with incident hip fracture and 400 control participants matched on the basis of age, race or ethnicity, and date of blood draw. Both groups were selected from 39 795 postmenopausal women who were not using estrogens or other bone-active therapies and who had not had a previous hip fracture. MEASUREMENTS: Serum 25(OH) vitamin D was measured and patients were followed for a median of 7.1 years (range, 0.7 to 9.3 years) to assess fractures. RESULTS: Mean serum 25(OH) vitamin D concentrations were lower in case-patients than in control participants (55.95 nmol/L [SD, 20.28] vs. 59.60 nmol/L [SD, 18.05]; P = 0.007), and lower serum 25(OH) vitamin D concentrations increased hip fracture risk (adjusted odds ratio for each 25-nmol/L decrease, 1.33 [95% CI, 1.06 to 1.68]). Women with the lowest 25(OH) vitamin D concentrations (< or =47.5 nmol/L) had a higher fracture risk than did those with the highest concentrations (> or =70.7 nmol/L) (adjusted odds ratio, 1.71 [CI, 1.05 to 2.79]), and the risk increased statistically significantly across quartiles of serum 25(OH) vitamin D concentration (P for trend = 0.016). This association was independent of number of falls, physical function, frailty, renal function, and sex-steroid hormone levels and seemed to be partially mediated by bone resorption. LIMITATIONS: Few case-patients were nonwhite women. Bone mineral density and parathyroid hormone levels were not accounted for in the analysis. CONCLUSION: Low serum 25(OH) vitamin D concentrations are associated with a higher risk for hip fracture. SN - 1539-3704 UR - https://www.unboundmedicine.com/medline/citation/18711154/Serum_25_hydroxyvitamin_D_concentrations_and_risk_for_hip_fractures_ L2 - https://www.acpjournals.org/doi/10.7326/0003-4819-149-4-200808190-00005?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -