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Selected ion flow tube mass spectrometry of exhaled breath condensate headspace.
Rapid Commun Mass Spectrom. 2008 Sep; 22(18):2844-50.RC

Abstract

Collection of exhaled breath condensate (EBC) is a relatively simple noninvasive method of breath analysis; however, no data have been reported that would relate concentration of volatile compounds in EBC to their gaseous concentrations in exhaled air. The aim of the study was to investigate which volatile compounds are present in EBC and how their concentrations relate to results of direct breath analysis. Thus, samples of EBC were collected in a standard way from several subjects and absolute levels of several common volatile breath metabolites (ammonia, acetone, ethanol, methanol, propanol, isoprene, hydrogen cyanide, formaldehyde and acetaldehyde) were then determined in their headspace using selected ion flow tube mass spectrometry (SIFT-MS). Results are compared with those from on-line breath analyses carried out immediately before collecting the EBC samples. It has been demonstrated that SIFT-MS can be used to quantify the concentrations of volatiles in EBC samples and that, for methanol, ammonia, ethanol and acetone, the EBC concentrations correlate with the direct breath levels. However, the EBC concentrations of isoprene, formaldehyde, acetaldehyde, hydrogen cyanide and propanol do not correlate with direct breath measurements.

Authors+Show Affiliations

Department of Allergology and Clinical Immunology, Hospital Na Homolce, Institute for Postgraduate Medical Education, Prague, Czech Republic.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

18712707

Citation

Cáp, Petr, et al. "Selected Ion Flow Tube Mass Spectrometry of Exhaled Breath Condensate Headspace." Rapid Communications in Mass Spectrometry : RCM, vol. 22, no. 18, 2008, pp. 2844-50.
Cáp P, Dryahina K, Pehal F, et al. Selected ion flow tube mass spectrometry of exhaled breath condensate headspace. Rapid Commun Mass Spectrom. 2008;22(18):2844-50.
Cáp, P., Dryahina, K., Pehal, F., & Spanel, P. (2008). Selected ion flow tube mass spectrometry of exhaled breath condensate headspace. Rapid Communications in Mass Spectrometry : RCM, 22(18), 2844-50. https://doi.org/10.1002/rcm.3685
Cáp P, et al. Selected Ion Flow Tube Mass Spectrometry of Exhaled Breath Condensate Headspace. Rapid Commun Mass Spectrom. 2008;22(18):2844-50. PubMed PMID: 18712707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Selected ion flow tube mass spectrometry of exhaled breath condensate headspace. AU - Cáp,Petr, AU - Dryahina,Kseniya, AU - Pehal,Frantisek, AU - Spanel,Patrik, PY - 2008/8/21/pubmed PY - 2008/10/31/medline PY - 2008/8/21/entrez SP - 2844 EP - 50 JF - Rapid communications in mass spectrometry : RCM JO - Rapid Commun Mass Spectrom VL - 22 IS - 18 N2 - Collection of exhaled breath condensate (EBC) is a relatively simple noninvasive method of breath analysis; however, no data have been reported that would relate concentration of volatile compounds in EBC to their gaseous concentrations in exhaled air. The aim of the study was to investigate which volatile compounds are present in EBC and how their concentrations relate to results of direct breath analysis. Thus, samples of EBC were collected in a standard way from several subjects and absolute levels of several common volatile breath metabolites (ammonia, acetone, ethanol, methanol, propanol, isoprene, hydrogen cyanide, formaldehyde and acetaldehyde) were then determined in their headspace using selected ion flow tube mass spectrometry (SIFT-MS). Results are compared with those from on-line breath analyses carried out immediately before collecting the EBC samples. It has been demonstrated that SIFT-MS can be used to quantify the concentrations of volatiles in EBC samples and that, for methanol, ammonia, ethanol and acetone, the EBC concentrations correlate with the direct breath levels. However, the EBC concentrations of isoprene, formaldehyde, acetaldehyde, hydrogen cyanide and propanol do not correlate with direct breath measurements. SN - 0951-4198 UR - https://www.unboundmedicine.com/medline/citation/18712707/Selected_ion_flow_tube_mass_spectrometry_of_exhaled_breath_condensate_headspace_ L2 - https://doi.org/10.1002/rcm.3685 DB - PRIME DP - Unbound Medicine ER -