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MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases.
Clin Genet. 2008 Oct; 74(4):307-15.CG

Abstract

MicroRNAs (miRNAs) consist of a class of evolutionarily conserved small non-coding RNA that regulates target messenger RNAs by mechanisms such as incomplete base pairing and post-transcriptional gene silencing. Recent studies have shown that aberrant miRNA expression is a common feature of many human disorders including aging, heart diseases, cancer, autoimmune diseases and others. It seems likely that miRNA expression levels can be used as novel diagnostic markers. MiRNAs may also provide a new strategy for therapeutic interventions. In this review, we focus on recent advances in understanding how miRNA changes contribute to disease development and their potential as novel biomarkers and therapeutic targets for human diseases.

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Authors+Show Affiliations

Wang Y
Department of Dermatology; and Department of Epigenetic Research Center, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
Liang Y
No affiliation info available
Lu Q
No affiliation info available

MeSH

Autoimmune DiseasesBiomarkersEpigenesis, GeneticGenetic TherapyHeart DiseasesHumansMicroRNAsModels, BiologicalNeoplasms

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

18713257

Citation

Wang, Y, et al. "MicroRNA Epigenetic Alterations: Predicting Biomarkers and Therapeutic Targets in Human Diseases." Clinical Genetics, vol. 74, no. 4, 2008, pp. 307-15.
Wang Y, Liang Y, Lu Q. MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases. Clin Genet. 2008;74(4):307-15.
Wang, Y., Liang, Y., & Lu, Q. (2008). MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases. Clinical Genetics, 74(4), 307-15. https://doi.org/10.1111/j.1399-0004.2008.01075.x
Wang Y, Liang Y, Lu Q. MicroRNA Epigenetic Alterations: Predicting Biomarkers and Therapeutic Targets in Human Diseases. Clin Genet. 2008;74(4):307-15. PubMed PMID: 18713257.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MicroRNA epigenetic alterations: predicting biomarkers and therapeutic targets in human diseases. AU - Wang,Y, AU - Liang,Y, AU - Lu,Q, Y1 - 2008/08/18/ PY - 2008/8/21/pubmed PY - 2008/11/19/medline PY - 2008/8/21/entrez SP - 307 EP - 15 JF - Clinical genetics JO - Clin Genet VL - 74 IS - 4 N2 - MicroRNAs (miRNAs) consist of a class of evolutionarily conserved small non-coding RNA that regulates target messenger RNAs by mechanisms such as incomplete base pairing and post-transcriptional gene silencing. Recent studies have shown that aberrant miRNA expression is a common feature of many human disorders including aging, heart diseases, cancer, autoimmune diseases and others. It seems likely that miRNA expression levels can be used as novel diagnostic markers. MiRNAs may also provide a new strategy for therapeutic interventions. In this review, we focus on recent advances in understanding how miRNA changes contribute to disease development and their potential as novel biomarkers and therapeutic targets for human diseases. SN - 1399-0004 UR - https://www.unboundmedicine.com/medline/citation/18713257/MicroRNA_epigenetic_alterations:_predicting_biomarkers_and_therapeutic_targets_in_human_diseases_ L2 - https://doi.org/10.1111/j.1399-0004.2008.01075.x DB - PRIME DP - Unbound Medicine ER -