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Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin, folate, and homocysteine status in Spanish adolescents.
Ann Nutr Metab 2008; 52(4):315-21AN

Abstract

BACKGROUND

Folate and cobalamin are responsible for healthy growth. However, the B-vitamin and homocysteine status of adolescents is not well known. The aim was to assess the status of folate, cobalamin, and homocysteine in healthy Spanish adolescents.

METHODS

Serum cobalamin, serum folate, homocysteine, methylenetetrahydrofolate reductase 677C>T variant, BMI, smoking habits, and Tanner stage were determined according to gender in 165 adolescents (84 females, 81 males; 13-18.5 years) using the Student's t test, Mann-Whitney U test and chi(2) test, respectively. Interactions between socioeconomic status, age group, methylenetetrahydrofolate reductase polymorphism, BMI, smoking habits, Tanner stage, and vitamin status, respectively, were examined by ANOVA or Kruskal-Wallis H test (p < 0.05).

RESULTS

Boys had markedly higher homocysteine (males 8.92 (5.51-22.94) micromol/l; females 7.91 (5.09-13.86) micromol/l), whereas girls showed higher serum cobalamin concentrations (males 540.00 (268.00-946.47) pmol/l; females 594.82 (280.63-1,559.64) pmol/l). Data are shown as medians and the 2.5th to 97.5th percentiles in parentheses. Adolescents with the homozygous variant of methylenetetrahydrofolate reductase displayed significantly higher homocysteine and lower serum folate: normal 5.73 (3.09-10.73) ng/ml serum folate, 7.57 (4.94-12.94) micromol/l homocysteine; homozygous 4.10 (2.75-7.88) ng/ml serum folate, 10.83 (7.00-22.82) micromol/l homocysteine.

CONCLUSION

The present study provides data on the folate, cobalamin, and homocysteine status of Spanish adolescents. To assure a better assessment, revision of references for adolescents is still needed.

Authors+Show Affiliations

Institut fur Ernahrungs- und Lebensmittelwissenschaften, Humanernahrung, Rheinische Friedrich-Wilhelms Universitat Bonn, Bonn, Deutschland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18714149

Citation

Al-Tahan, Jasmin, et al. "Methylenetetrahydrofolate Reductase 677CT Polymorphism and Cobalamin, Folate, and Homocysteine Status in Spanish Adolescents." Annals of Nutrition & Metabolism, vol. 52, no. 4, 2008, pp. 315-21.
Al-Tahan J, Sola R, Ruiz JR, et al. Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin, folate, and homocysteine status in Spanish adolescents. Ann Nutr Metab. 2008;52(4):315-21.
Al-Tahan, J., Sola, R., Ruiz, J. R., Breidenassel, C., García-Fuentes, M., Moreno, L. A., ... González-Gross, M. (2008). Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin, folate, and homocysteine status in Spanish adolescents. Annals of Nutrition & Metabolism, 52(4), pp. 315-21. doi:10.1159/000151485.
Al-Tahan J, et al. Methylenetetrahydrofolate Reductase 677CT Polymorphism and Cobalamin, Folate, and Homocysteine Status in Spanish Adolescents. Ann Nutr Metab. 2008;52(4):315-21. PubMed PMID: 18714149.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin, folate, and homocysteine status in Spanish adolescents. AU - Al-Tahan,Jasmin, AU - Sola,Ricardo, AU - Ruiz,Jonatan R, AU - Breidenassel,Christina, AU - García-Fuentes,Miguel, AU - Moreno,Luis A, AU - Castillo,Manuel, AU - Pietrzik,Klaus, AU - González-Gross,Marcela, Y1 - 2008/08/19/ PY - 2007/07/23/received PY - 2008/03/13/accepted PY - 2008/8/21/pubmed PY - 2008/12/17/medline PY - 2008/8/21/entrez SP - 315 EP - 21 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 52 IS - 4 N2 - BACKGROUND: Folate and cobalamin are responsible for healthy growth. However, the B-vitamin and homocysteine status of adolescents is not well known. The aim was to assess the status of folate, cobalamin, and homocysteine in healthy Spanish adolescents. METHODS: Serum cobalamin, serum folate, homocysteine, methylenetetrahydrofolate reductase 677C>T variant, BMI, smoking habits, and Tanner stage were determined according to gender in 165 adolescents (84 females, 81 males; 13-18.5 years) using the Student's t test, Mann-Whitney U test and chi(2) test, respectively. Interactions between socioeconomic status, age group, methylenetetrahydrofolate reductase polymorphism, BMI, smoking habits, Tanner stage, and vitamin status, respectively, were examined by ANOVA or Kruskal-Wallis H test (p < 0.05). RESULTS: Boys had markedly higher homocysteine (males 8.92 (5.51-22.94) micromol/l; females 7.91 (5.09-13.86) micromol/l), whereas girls showed higher serum cobalamin concentrations (males 540.00 (268.00-946.47) pmol/l; females 594.82 (280.63-1,559.64) pmol/l). Data are shown as medians and the 2.5th to 97.5th percentiles in parentheses. Adolescents with the homozygous variant of methylenetetrahydrofolate reductase displayed significantly higher homocysteine and lower serum folate: normal 5.73 (3.09-10.73) ng/ml serum folate, 7.57 (4.94-12.94) micromol/l homocysteine; homozygous 4.10 (2.75-7.88) ng/ml serum folate, 10.83 (7.00-22.82) micromol/l homocysteine. CONCLUSION: The present study provides data on the folate, cobalamin, and homocysteine status of Spanish adolescents. To assure a better assessment, revision of references for adolescents is still needed. SN - 1421-9697 UR - https://www.unboundmedicine.com/medline/citation/18714149/Methylenetetrahydrofolate_reductase_677CT_polymorphism_and_cobalamin_folate_and_homocysteine_status_in_Spanish_adolescents_ L2 - https://www.karger.com?DOI=10.1159/000151485 DB - PRIME DP - Unbound Medicine ER -