Tags

Type your tag names separated by a space and hit enter

In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain.
Diagn Microbiol Infect Dis. 2008 Oct; 62(2):210-5.DM

Abstract

In vitro cefditoren antimicrobial activity was tested against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in our hospital from January 2005 to May 2006 by agar dilution and broth microdilution method, respectively. MICs were also determined for 13 and 10 comparison drugs, respectively. The pneumococci tested comprised 113 (39.2%) penicillin susceptible, 91 (31.6%) penicillin intermediate, and 84 (29.2%) penicillin resistant. Cefditoren was the most active drug on the basis of the MICs (MIC(90)=0.5 microg/mL), followed by ceftriaxone and levofloxacin (MIC(90)=1 microg/mL). Cefditoren MICs ranged from 0.25 to 1 microg/mL for ceftriaxone-resistant isolates, with a modal MIC of 0.5 microg/mL and an MIC(90) of 1.0 microg/mL. No S. pneumoniae isolates evaluated in this study showed MICs to cefditoren higher than 1 microg/mL (MIC range, <or=0.015 to 1 microg/mL). Against penicillin-resistant pneumococci, the rank order of intrinsic activity (MIC(90), microg/mL) was cefditoren (0.5)<ceftriaxone (2.0)=cefotaxime (2.0)<amoxicillin/clavulanate (8.0)=amoxicillin (8.0)=cefuroxime (8.0). Among the 220 strains of H. influenzae, 42 (19.09%) produced a beta-lactamase (Hi beta+) and 3 (1.1%) were beta-lactamase (Hi beta-) negative but have reduced susceptibility to ampicillin (BLNAR). The most active drugs on the basis of MICs were cefditoren and levofloxacin, showing MIC(50) and MIC(90) values of 0.015/0.06 microg/mL. Cefditoren at concentration of 0.06 microg/mL inhibited all 3 BLNAR (ampicillin MICs >4 microg/mL). Against H. influenzae (Hi beta+), the rank order of intrinsic activity (MIC(90), microg/mL) was cefditoren (0.03) < cefixime (0.06)<ceftriaxone (0.12)=cefotaxime (0.12)<cefuroxime (1.0)<amoxicillin/clavulanate (2.0)<ampicillin (>8.0).

Authors+Show Affiliations

Department of Microbiology, Hospital Clinico Lozano Blesa, 50009 Zaragoza, Spain. cristinaseral@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

18715733

Citation

Seral, Cristina, et al. "In Vitro Activity of Cefditoren and Other Antimicrobial Agents Against 288 Streptococcus Pneumoniae and 220 Haemophilus Influenzae Clinical Strains Isolated in Zaragoza, Spain." Diagnostic Microbiology and Infectious Disease, vol. 62, no. 2, 2008, pp. 210-5.
Seral C, Suárez L, Rubio-Calvo C, et al. In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain. Diagn Microbiol Infect Dis. 2008;62(2):210-5.
Seral, C., Suárez, L., Rubio-Calvo, C., Gómez-Lus, R., Gimeno, M., Coronel, P., Durán, E., Becerril, R., Oca, M., & Castillo, F. J. (2008). In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain. Diagnostic Microbiology and Infectious Disease, 62(2), 210-5. https://doi.org/10.1016/j.diagmicrobio.2008.06.007
Seral C, et al. In Vitro Activity of Cefditoren and Other Antimicrobial Agents Against 288 Streptococcus Pneumoniae and 220 Haemophilus Influenzae Clinical Strains Isolated in Zaragoza, Spain. Diagn Microbiol Infect Dis. 2008;62(2):210-5. PubMed PMID: 18715733.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro activity of cefditoren and other antimicrobial agents against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in Zaragoza, Spain. AU - Seral,Cristina, AU - Suárez,Laura, AU - Rubio-Calvo,Carmen, AU - Gómez-Lus,Rafael, AU - Gimeno,Mercedes, AU - Coronel,Pilar, AU - Durán,Estrella, AU - Becerril,Raquel, AU - Oca,Mercedes, AU - Castillo,F Javier, Y1 - 2008/08/20/ PY - 2008/05/05/received PY - 2008/06/11/revised PY - 2008/06/25/accepted PY - 2008/8/22/pubmed PY - 2008/11/18/medline PY - 2008/8/22/entrez SP - 210 EP - 5 JF - Diagnostic microbiology and infectious disease JO - Diagn Microbiol Infect Dis VL - 62 IS - 2 N2 - In vitro cefditoren antimicrobial activity was tested against 288 Streptococcus pneumoniae and 220 Haemophilus influenzae clinical strains isolated in our hospital from January 2005 to May 2006 by agar dilution and broth microdilution method, respectively. MICs were also determined for 13 and 10 comparison drugs, respectively. The pneumococci tested comprised 113 (39.2%) penicillin susceptible, 91 (31.6%) penicillin intermediate, and 84 (29.2%) penicillin resistant. Cefditoren was the most active drug on the basis of the MICs (MIC(90)=0.5 microg/mL), followed by ceftriaxone and levofloxacin (MIC(90)=1 microg/mL). Cefditoren MICs ranged from 0.25 to 1 microg/mL for ceftriaxone-resistant isolates, with a modal MIC of 0.5 microg/mL and an MIC(90) of 1.0 microg/mL. No S. pneumoniae isolates evaluated in this study showed MICs to cefditoren higher than 1 microg/mL (MIC range, <or=0.015 to 1 microg/mL). Against penicillin-resistant pneumococci, the rank order of intrinsic activity (MIC(90), microg/mL) was cefditoren (0.5)<ceftriaxone (2.0)=cefotaxime (2.0)<amoxicillin/clavulanate (8.0)=amoxicillin (8.0)=cefuroxime (8.0). Among the 220 strains of H. influenzae, 42 (19.09%) produced a beta-lactamase (Hi beta+) and 3 (1.1%) were beta-lactamase (Hi beta-) negative but have reduced susceptibility to ampicillin (BLNAR). The most active drugs on the basis of MICs were cefditoren and levofloxacin, showing MIC(50) and MIC(90) values of 0.015/0.06 microg/mL. Cefditoren at concentration of 0.06 microg/mL inhibited all 3 BLNAR (ampicillin MICs >4 microg/mL). Against H. influenzae (Hi beta+), the rank order of intrinsic activity (MIC(90), microg/mL) was cefditoren (0.03) < cefixime (0.06)<ceftriaxone (0.12)=cefotaxime (0.12)<cefuroxime (1.0)<amoxicillin/clavulanate (2.0)<ampicillin (>8.0). SN - 0732-8893 UR - https://www.unboundmedicine.com/medline/citation/18715733/In_vitro_activity_of_cefditoren_and_other_antimicrobial_agents_against_288_Streptococcus_pneumoniae_and_220_Haemophilus_influenzae_clinical_strains_isolated_in_Zaragoza_Spain_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0732-8893(08)00295-2 DB - PRIME DP - Unbound Medicine ER -